Review
Biochemistry & Molecular Biology
Hye Min Kim, Min Kook Kang, Se Yoon Seong, Jun Hyeon Jo, Min Ju Kim, Eun Kyeong Shin, Chang Geun Lee, Seung Jin Han
Summary: All eukaryotic cells, including oocytes, use cyclin-dependent kinase (Cdk) as an engine to drive the cell cycle. The key regulator of the oocyte cell cycle is the Cdk1-cyclin B1 complex. Recent studies have discovered the roles of other cyclins in mouse oocyte cell cycle regulation, as well as the translation and degradation of cyclins to modulate Cdk activity. This review provides new insights into the regulatory role and function of cyclins in oocyte cell cycle progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yumi Hoshino, Takafumi Uchida
Summary: Pin1, an enzyme that regulates the function of phosphorylated proteins, plays a crucial role in meiotic maturation. By altering the structure of proline peptide bond in proteins, Pin1 controls the progression of meiosis and affects the extrusion of polar bodies. The functional regulation of Pin1 is essential for oocyte production and holds potential applications in reproductive medicine and animal breeding.
Article
Cell Biology
Kimiya Matsuda, Daiki Hirayama, Naoya Hino, Sota Kuno, Asako Sakaue-Sawano, Atsushi Miyawaki, Michiyuki Matsuda, Kenta Terai
Summary: The roles of each ErbB receptor in the proliferation, migration and survival of epithelial cells were investigated by systematically knocking out each ErbB gene or their combinations. ErbB1 was found to play a primary role in collective cell migration, followed by the ErbB2 and ErbB3 heterodimer. Either ErbB1 or the ErbB2 and ErbB3 complex was sufficient for promoting G1/S progression. Interestingly, ligand-independent ErbB2 activity was found to prevent apoptosis at high cell density.
JOURNAL OF CELL SCIENCE
(2023)
Article
Cell Biology
Kimiya Matsuda, Daiki Hirayama, Naoya Hino, Sota Kuno, Asako Sakaue-Sawano, Atsushi Miyawaki, Michiyuki Matsuda, Kenta Terai
Summary: The ErbB-family receptors play important roles in the proliferation, migration, and survival of epithelial cells. Knockout studies reveal that ErbB1 primarily mediates ERK1/ERK2 activation during collective cell migration, followed by the ErbB2 and ErbB3 heterodimer. Both ErbB1 and ErbB2/ErbB3 complex are sufficient for G1/S progression, and ligand-independent ErbB2 activity prevents apoptosis at high cell density.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Nina M. Alyoshina, Maria D. Tkachenko, Yulia O. Nikishina, Denis A. Nikishin
Summary: This study found that the activity of serotonin transporter (SERT) in oocytes is correlated with indicators of follicular selection and oocyte maturity. The accumulation of exogenous serotonin in maturing mammalian oocytes occurs due to SERT activity. Immunohistochemical study showed that the difference in 5-HT intake activity in oocytes does not correlate with apoptosis marker in follicular cells, but positively correlates with markers of follicular growth. Functional analysis showed that SERT expression and activity increase with oocyte maturation. Administration of fluoxetine, a selective serotonin reuptake inhibitor, significantly decreases serotonin content in growing and mature oocytes, indicating that membrane transport of serotonin is a promising marker of their mature status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Thaisy Tino Dellaqua, Renan Aparecido Vigaro, Ludimila Cardoso Zoccal Janini, Mariabeatrice Dal Canto, Mario Mignini Renzini, Valentina Lodde, Alberto Maria Luciano, Jose Buratini
Summary: This study assessed the effects of NRG1 on oocyte nuclear maturation, cumulus expansion, and mRNA expression during IVM, as well as post-IVF embryo development in cattle. The results showed that NRG1 enhanced oocyte developmental competence and embryo development without affecting cumulus expansion. It is the first study to report the modulatory effect of NRG1 during oocyte maturation in a mono-ovulatory species and the potential for improving post-IVF embryo development.
Article
Cell Biology
Yue Zhang, Qiong Wu, Guanglin Niu, Jidan Liu, Fangjun Cao, Xiaopeng An, Binyun Cao
Summary: This study found that EGF can regulate apoptosis and inflammation in gMEC by inducing the expression of miR-223. The downregulation of ISG15 by EGF and miR-223 is a key factor in this regulatory process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Alison J. May, Aaron J. Mattingly, Eliza A. Gaylord, Nathan Griffin, Sonia Sudiwala, Noel Cruz-Pacheco, Elaine Emmerson, Seayar Mohabbat, Sara Nathan, Hanan Sinada, Isabelle M. A. Lombaert, Sarah M. Knox
Summary: Neuronal-epithelial cross-talk drives acinar specification through NRG1-ERBB3-mTORC2 signaling. NRG1-ERBB3 regulates the cellular programs of lineage progression, secretion, and polarization through the mTORC2 signaling pathway. This mechanism plays a crucial role in the formation of functional acini.
DEVELOPMENTAL CELL
(2022)
Review
Pharmacology & Pharmacy
Lucas T. Woods, Kevin Munoz Forti, Vinit C. Shanbhag, Jean M. Camden, Gary A. Weisman
Summary: The text discusses the important role of purinergic receptors for extracellular nucleotides and nucleosides in cellular and tissue functions, and provides insights into the composition of the purinergic receptor system in mammals and recent research findings. It highlights the significance of specific P2Y receptor subtypes in cancer progression and discusses the use of pharmacological and genetic strategies to study cell-specific and P2Y receptor subtype-specific responses. Additionally, it mentions the bioinformatic and empirical evidence on P2Y receptor expression in human clinical specimens and the potential therapeutic relevance of P2Y receptor-targeting interventions in cancer treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Soo-Hyun Park, Pil-Soo Jeong, Ye Eun Joo, Hyo-Gu Kang, Min Ju Kim, Sanghoon Lee, Bong-Seok Song, Sun-Uk Kim, Seong-Keun Cho, Bo-Woong Sim
Summary: Luteolin, as an antioxidant, plays a significant protective role in the in vitro maturation of oocytes, improving rates of polar body extrusion and blastocyst formation, enhancing gene expression, reducing intracellular reactive oxygen species, and ameliorating cell organelle defects caused by oxidative stress. Additionally, luteolin improves developmental competence of in vitro-fertilized embryos and restores competencies decreased by oxidative stress, shedding light on the relationship between oxidative stress and oocyte maturation processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Kathrin Hedegger, Andreas Blutke, Theresa Hommel, Kerstin E. E. Auer, Nishanth B. B. Nataraj, Moshit Lindzen, Yosef Yarden, Maik Dahlhoff
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly cancer, and targeted therapies for PDAC are still under development. This study shows that simultaneously blocking the entire ERBB receptor family, using a molecular decoy called TRAP-F-C, can effectively reduce pancreatic tumor burden and RAS activity in a mouse model of PDAC.
MOLECULAR ONCOLOGY
(2023)
Article
Genetics & Heredity
Julia Koch, Valerio Marques Portela, Esdras Correa dos Santos, Daniele Missio, Leonardo Guedes de Andrade, Zigomar da Silva, Bernardo Garziera Gasperin, Alfredo Quites Antoniazzi, Paulo Bayard Dias Goncalves, Gustavo Zamberlam
Summary: This study found that the inhibition of the interaction between the Hippo effector YAP or its transcriptional co-activator TAZ with the TEAD family of transcription factors is critical for the cumulus expansion-related events induced by the EGF network in cumulus-oocyte complexes (COCs). These findings provide important insights into the functional relevance of cumulus expansion and oocyte maturation in monovulatory species, and may serve as potential targets to improve the efficiency of in vitro maturation (IVM) systems.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yanting Wang, Xianyue Ren, Weiyu Li, Ruoyan Cao, Suyang Liu, Laibo Jiang, Bin Cheng, Juan Xia
Summary: SPDEF acts as a tumor suppressor in HNSCC by transcriptionally activating NR4A1, leading to inhibition of AKT, MAPK, and NF-kappa B signaling pathways. Low expression of SPDEF is associated with poor clinical outcomes in HNSCC patients, and restoration of SPDEF inhibits cell proliferation in HNSCC.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Article
Oncology
Chongqing Gao, Jing Li, Fuling Zeng, Lijuan Wang, Kaiyun Chen, Dong Chen, Jian Hong, Chen Qu
Summary: MCM6, a novel diagnostic biomarker, is upregulated in intrahepatic cholangiocarcinoma (ICC) and associated with poor prognosis. It promotes ICC progression by activating the E2F1-mediated epithelial-mesenchymal transition (EMT) and enhances the proliferation and migration of ICC cells.
Article
Engineering, Environmental
Jiyeon Leem, Seul Kim, Jae-Sung Kim, Jeong Su Oh
Summary: In this study, the effects of exposure to 9,10-phenanthrenequinone (9,10-PQ) were investigated using mouse oocytes as a model system. It was found that 9,10-PQ compromised meiotic maturation by impairing the assembly of the microtubule organizing center and subsequent spindle formation. Additionally, 9,10-PQ exposure inhibited cell cycle progression by disrupting the accumulation of cyclin B1 and the activation of Cdk1. Importantly, the meiotic defects induced by 9,10-PQ were not rescued by decreasing reactive oxygen species (ROS) levels, indicating that 9,10-PQ has ROS-independent activity in regulating cell cycle progression and spindle assembly.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemical Research Methods
Shanthi Kanthala, Christopher P. Mill, David J. Riese, Mihir Jaiswal, Seetharama Jois
PROTEIN EXPRESSION AND PURIFICATION
(2016)
Article
Veterinary Sciences
Farruk M. Lutful Kabir, Patricia DeInnocentes, Payal Agarwal, Christopher P. Mill, David J. Riese, R. Curtis Bird
JOURNAL OF VETERINARY SCIENCE
(2017)
Article
Education, Scientific Disciplines
Rondall E. Allen, Jeffrey Copeland, Andrea S. Franks, Reza Karimi, Marianne McCollum, David J. Riese, Anne Y. F. Lin
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
(2013)
Article
Biochemistry & Molecular Biology
Kristy J. Wilson, Christopher P. Mill, Richard M. Gallo, Elizabeth M. Cameron, Henry VanBrocklin, Jeffrey Settleman, David J. Riese
BIOCHEMICAL JOURNAL
(2012)
Article
Biochemical Research Methods
Michael D. Zordan, Christopher P. Mill, David J. Riese, James F. Leary
Article
Oncology
Christopher P. Mill, Kathleen L. Gettinger, David J. Riese
EXPERIMENTAL CELL RESEARCH
(2011)
Review
Pharmacology & Pharmacy
David J. Riese
EXPERT OPINION ON DRUG DISCOVERY
(2011)
Article
Cell Biology
Kristy J. Wilson, Christopher Mill, Sydney Lambert, Jennifer Buchman, Timothy R. Wilson, Victor Hernandez-Gordillo, Richard M. Gallo, Laura M. C. Ades, Jeffrey Settleman, David J. Riese
Article
Biochemistry & Molecular Biology
Brian G. Coon, Debarati Mukherjee, Claudia B. Hanna, David J. Riese, Martin Lowe, R. Claudio Aguilar
HUMAN MOLECULAR GENETICS
(2009)
Review
Dentistry, Oral Surgery & Medicine
John Foley, Nicole Nickerson, David J. Riese, Peter C. Hollenhorst, Gwendolen Lorch, Anne M. Foley
Article
Oncology
Nicole K. Nickerson, Christopher P. Mill, Hsin-Jung Wu, David J. Riese, John Foley
Article
Multidisciplinary Sciences
Richard L. Cullum, Lauren M. Lucas, Jared I. Senfeld, John T. Piazza, Logan T. Neel, Kanupriya Whig, Ling Zhai, Mackenzie H. Harris, Cristina C. Rael, Darby C. Taylor, Laura J. Cook, David P. Kaufmann, Christopher P. Mill, Megan A. Jacobi, Forrest T. Smith, Mark Suto, Robert Bostwick, Ram B. Gupta, Allan E. David, David J. Riese
Review
Pharmacology & Pharmacy
Yi Shi, David J. Riese, Jianzhong Shen
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Pharmacology & Pharmacy
Lauren M. Lucas, Vipasha Dwivedi, Jared Senfeld, Richard L. Cullum, Christopher P. Mill, J. Tyler Piazza, Ianthe N. Bryant, Laura J. Cook, S. Tyler Miller, James H. Lott, Connor M. Kelley, Elizabeth L. Knerr, Jessica A. Markham, David P. Kaufmann, Megan A. Jacobi, Jianzhong Shen, David J. Riese
Summary: This review explores the function of ERBB4 in human malignancies, discussing its potential as both a tumor suppressor and an oncogene. It also examines the specific roles of ERBB4 in various tumors and evaluates the potential use of ERBB4 mutants as biomarkers and in tumor staging and treatment.
PHARMACOLOGICAL REVIEWS
(2022)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)