Molecular mechanisms for enhanced DNA vaccine immunogenicity

Vector optimization and needle-free intradermal application of a broadly protective polyvalent influenza A DNA vaccine for pigs and humans

(2015) Marie Borggren et al.   Human Vaccines & Immunotherapeutics

DNA vaccines, electroporation and their applications in cancer treatment

(2015) Si-Hyeong Lee et al.   Human Vaccines & Immunotherapeutics

Microneedles: an innovative platform for gene delivery

(2015) Joanne McCaffrey et al.   Drug Delivery and Translational Research

HIV-DNA Given with or without Intradermal Electroporation Is Safe and Highly Immunogenic in Healthy Swedish HIV-1 DNA/MVA Vaccinees: A Phase I Randomized Trial

(2015) Charlotta Nilsson et al.   PLoS One

Comparing the effect of Toll-like receptor agonist adjuvants on the efficiency of a DNA vaccine

(2014) Azadeh Sajadian et al.   ARCHIVES OF VIROLOGY

The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma

(2014) Pallab Pradhan et al.   BIOMATERIALS

DNAVaxDB: the first web-based DNA vaccine database and its data analysis

(2014) Rebecca Racz et al.   BMC BIOINFORMATICS

Protective efficacy of Toxoplasma gondiicalcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice

(2014) Jia Chen et al.   BMC INFECTIOUS DISEASES

A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation

(2014) J.W. Hooper et al.   CLINICAL MICROBIOLOGY AND INFECTION

Improving DNA Vaccine Performance Through Vector Design

(2014) James Williams   CURRENT GENE THERAPY

Plasmids Encoding Protein Aggregation Domains Act As Molecular Adjuvants for DNA Vaccines

(2014) Melamia Capitani et al.   CURRENT GENE THERAPY

IFI16: At the interphase between innate DNA sensing and genome regulation

(2014) Martin R. Jakobsen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting DNA vaccines to myeloid cells using a small peptide

(2014) Chunting Ye et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Electroporation-enhanced delivery of nucleic acid vaccines

(2014) Kate E Broderick et al.   Expert Review of Vaccines

Short noncoding DNA fragments improve the immune potency of electroporation-mediated HBV DNA vaccination

(2014) J Peng et al.   GENE THERAPY

Exploitation of Langerhans cells for in vivo DNA vaccine delivery into the lymph nodes

(2014) E R Tőke et al.   GENE THERAPY

The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization

(2014) M Smahel et al.   GENE THERAPY

Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells

(2014) C Bergamaschi et al.   GENE THERAPY

Variable effects of the co-administration of a GM-CSF-expressing plasmid on the immune response to flavivirus DNA vaccines in mice

(2014) Hui Chen et al.   IMMUNOLOGY LETTERS

CpG/Poly (I:C) mixed adjuvant priming enhances the immunogenicity of a DNA vaccine against eastern equine encephalitis virus in mice

(2014) JinZhu Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nanoparticles for DNA Vaccine Delivery

(2014) Muhammad Ali A. Shah et al.   Journal of Biomedical Nanotechnology

Identification of Aim2 as a Sensor for DNA Vaccines

(2014) John J. Suschak et al.   JOURNAL OF IMMUNOLOGY

The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β duringChlamydia trachomatisInfection

(2014) Yugen Zhang et al.   JOURNAL OF IMMUNOLOGY

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Summary of bi-shRNAfurin/GM-CSF Augmented Autologous Tumor Cell Immunotherapy (FANG™) in Advanced Cancer of the Liver

(2014) John Nemunaitis et al.   ONCOLOGY

CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene

(2014) Deyong Chu et al.   PARASITOLOGY INTERNATIONAL

Regulation of HIV-Gag Expression and Targeting to the Endolysosomal/Secretory Pathway by the Luminal Domain of Lysosomal-Associated Membrane Protein (LAMP-1) Enhance Gag-Specific Immune Response

(2014) Rodrigo Maciel da Costa Godinho et al.   PLoS One

Protective Effect of DNA Vaccine Encoding Pseudomonas Exotoxin A and PcrV against Acute Pulmonary P. aeruginosa Infection

(2014) Mingzi Jiang et al.   PLoS One

Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system

(2014) N. Sugimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization

(2014) Anushi E Rajapaksa et al.   RESPIRATORY RESEARCH

A critical analysis of codon optimization in human therapeutics

(2014) Vincent P. Mauro et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy-targeted vaccine of LC3–LpqH DNA and its protective immunity in a murine model of tuberculosis

(2014) Dong Hu et al.   VACCINE

Synergy of mIL-21 and mIL-15 in enhancing DNA vaccine efficacy against acute and chronic Toxoplasma gondii infection in mice

(2014) Zhong-Yuan Li et al.   VACCINE

Nucleic acid sensing by T cells initiates Th2 cell differentiation

(2014) Takayuki Imanishi et al.   Nature Communications

DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice

(2013) Jun Cao et al.   BMC IMMUNOLOGY

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice

(2013) Jingying Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection

(2013) Jamie F.S. Mann et al.   JOURNAL OF CONTROLLED RELEASE

Codon-optimized expression of fish iridovirus capsid protein in yeast and its application as an oral vaccine candidate

(2013) J Y Seo et al.   JOURNAL OF FISH DISEASES

A Heterologous Prime/Boost Vaccination Strategy Enhances the Immunogenicity of Therapeutic Vaccines for Hepatitis C Virus

(2013) Anne Fournillier et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery

(2013) Spyros A. Kalams et al.   JOURNAL OF INFECTIOUS DISEASES

DNA Priming Prior to Inactivated Influenza A(H5N1) Vaccination Expands the Antibody Epitope Repertoire and Increases Affinity Maturation in a Boost-Interval–Dependent Manner in Adults

(2013) Surender Khurana et al.   JOURNAL OF INFECTIOUS DISEASES

Prime-Boost Interval Matters: A Randomized Phase 1 Study to Identify the Minimum Interval Necessary to Observe the H5 DNA Influenza Vaccine Priming Effect

(2013) Julie E. Ledgerwood, Kathryn Zephir, Zonghui Hu, Chih-Jen Wei, LeeJah Chang, Mary E. Enama, Cynthia S. Hendel, Sandra Sitar, Robert T. Bailer, Richard A. Koup, John R. Mascola, Gary J. Nabel, Barney S. Graham et al.   JOURNAL OF INFECTIOUS DISEASES

Oral vaccination with a liposome-encapsulated influenza DNA vaccine protects mice against respiratory challenge infection

(2013) Jing Liu et al.   JOURNAL OF MEDICAL VIROLOGY

COStar: A D-star Lite-based dynamic search algorithm for codon optimization

(2013) Xiaowu Liu et al.   JOURNAL OF THEORETICAL BIOLOGY

In Vivo Electroporation of Minicircle DNA as a Novel Method of Vaccine Delivery To Enhance HIV-1-Specific Immune Responses

(2013) Q. Wang et al.   JOURNAL OF VIROLOGY

A Mini-intronic Plasmid (MIP): A Novel Robust Transgene Expression Vector In Vivo and In Vitro

(2013) Jiamiao Lu et al.   MOLECULAR THERAPY

Minicircle DNA is Superior to Plasmid DNA in Eliciting Antigen-specific CD8+ T-cell Responses

(2013) Wynette M Dietz et al.   MOLECULAR THERAPY

Co-transfection Gene Delivery of Dendritic Cells Induced Effective Lymph Node Targeting and Anti-tumor Vaccination

(2013) Yu-Zhe Chen et al.   PHARMACEUTICAL RESEARCH

DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity

(2013) Ilin Chuang et al.   PLoS One

DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency of Priming for Antibody and CD8+ T-Cell Responses after rAd5 Boost in a Randomized Clinical Trial

(2013) Barney S. Graham et al.   PLoS One

Dry-Coated Live Viral Vector Vaccines Delivered by Nanopatch Microprojections Retain Long-Term Thermostability and Induce Transgene-Specific T Cell Responses in Mice

(2013) Frances E. Pearson et al.   PLoS One

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biological approaches to measure and understand vaccine immunity in humans

(2013) Shuzhao Li et al.   SEMINARS IN IMMUNOLOGY

HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques

(2013) Jinyao Li et al.   VACCINE

Expression of chicken parvovirus VP2 in chicken embryo fibroblasts requires codon optimization for production of naked DNA and vectored meleagrid herpesvirus type 1 vaccines

(2013) Stephen J. Spatz et al.   VIRUS GENES

Codon optimization and woodchuck hepatitis virus posttranscriptional regulatory element enhance the immune responses of DNA vaccines against infectious bursal disease virus in chickens

(2013) Kai Li et al.   VIRUS RESEARCH

Interleukin-12 as a genetic adjuvant enhances hepatitis C virus NS3 DNA vaccine immunogenicity

(2013) Malihe Naderi et al.   VIROLOGICA SINICA

Targeting dendritic cells with antigen via dendritic cell-associated promoters

(2012) V Moulin et al.   CANCER GENE THERAPY

Technologies for enhanced efficacy of DNA vaccines

(2012) Fadi Saade et al.   Expert Review of Vaccines

Short noncoding DNA fragment improve efficiencies ofin vivoelectroporation-mediated gene transfer

(2012) Jinliang Peng et al.   JOURNAL OF GENE MEDICINE

A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Aβ42 DNA vaccine for Alzheimer disease

(2012) Doris Lambracht-Washington et al.   JOURNAL OF NEUROIMMUNOLOGY

A Sendai Virus-Derived RNA Agonist of RIG-I as a Virus Vaccine Adjuvant

(2012) L. Martínez-Gil et al.   JOURNAL OF VIROLOGY

Preliminary evaluation of DNA vaccine candidates encoding dengue-2 prM/E and NS1: Their immunity and protective efficacy in mice

(2012) Hui Lu et al.   MOLECULAR IMMUNOLOGY

Airway CD8+ T cells induced by pulmonary DNA immunization mediate protective anti-viral immunity

(2012) M Bivas-Benita et al.   Mucosal Immunology

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Comparing the effect of IL-12 genetic adjuvant and alum non-genetic adjuvant on the efficiency of the cocktail DNA vaccine containing plasmids encoding SAG-1 and ROP-2 of Toxoplasma gondii

(2012) Kamy Hosseinian Khosroshahi et al.   PARASITOLOGY RESEARCH

MDA5 Can Be Exploited as Efficacious Genetic Adjuvant for DNA Vaccination against Lethal H5N1 Influenza Virus Infection in Chickens

(2012) Matthias Liniger et al.   PLoS One

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification

(2012) M. Oldenburg et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Enhancement of immune response to a DNA vaccine against Mycobacterium tuberculosis Ag85B by incorporation of an autophagy inducing system

(2012) Jomkhwan Meerak et al.   VACCINE

Prime-boost BCG vaccination with DNA vaccines based in β-defensin-2 and mycobacterial antigens ESAT6 or Ag85B improve protection in a tuberculosis experimental model

(2012) Alberto R. Cervantes-Villagrana et al.   VACCINE

Sequential administration of cytokine genes to enhance cellular immune responses and CD4+T memory cells during DNA vaccination

(2012) Baowei Su et al.   Human Vaccines & Immunotherapeutics

Co-expression of HIV-1 virus-like particles and granulocyte-macrophage colony stimulating factor by GEO-D03 DNA vaccine

(2012) Michael Hellerstein et al.   Human Vaccines & Immunotherapeutics

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice

(2011) Jon Hansen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Peptide-Conjugated PAMAM Dendrimer as a Universal DNA Vaccine Platform to Target Antigen-Presenting Cells

(2011) P. Daftarian et al.   CANCER RESEARCH

Blocking the immunosuppressive axis with small interfering RNA targeting interleukin (IL)-10 receptor enhances dendritic cell-based vaccine potency

(2011) J. H. Kim et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Modulation of Plasmid DNA Vaccine Antigen Clearance by Caspase 12 RNA Interference Potentiates Vaccination

(2011) Ralf Geiben-Lynn et al.   Clinical and Vaccine Immunology

The Nasal Dendritic Cell-Targeting Flt3 Ligand as a Safe Adjuvant Elicits Effective Protection against Fatal Pneumococcal Pneumonia

(2011) Kosuke Kataoka et al.   INFECTION AND IMMUNITY

Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization

(2011) Xianfeng Chen et al.   JOURNAL OF CONTROLLED RELEASE

HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable

(2011) S. C. De Rosa et al.   JOURNAL OF IMMUNOLOGY

Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype

(2011) M. H. Lahoud et al.   JOURNAL OF IMMUNOLOGY

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

(2011) Julie E Ledgerwood et al.   LANCET INFECTIOUS DISEASES

Solving vaccine mysteries: a systems biology perspective

(2011) Lydie Trautmann et al.   NATURE IMMUNOLOGY

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Minicircle-oriP-IFNγ: A Novel Targeted Gene Therapeutic System for EBV Positive Human Nasopharyngeal Carcinoma

(2011) Yufang Zuo et al.   PLoS One

Safety and Immunogenicity of an HIV Adenoviral Vector Boost after DNA Plasmid Vaccine Prime by Route of Administration: A Randomized Clinical Trial

(2011) Beryl A. Koblin et al.   PLoS One

A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade rAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204)

(2011) Gavin J. Churchyard et al.   PLoS One

Blockade of B7-H1 enhances dendritic cell-mediated T cell response and antiviral immunity in HBV transgenic mice

(2011) Wenzheng Jiang   VACCINE

RNA interference-mediated silencing of Foxo3 in antigen-presenting cells as a strategy for the enhancement of DNA vaccine potency

(2010) S-T Wang et al.   GENE THERAPY

Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers

(2010) J M Luke et al.   GENE THERAPY

A Short Polypeptide from the Herpes Simplex Virus Type 2 ICP10 Gene Can Induce Antigen Aggregation and Autophagosomal Degradation for Enhanced Immune Presentation

(2010) Xinping Fu et al.   HUMAN GENE THERAPY

DNA vaccines: an historical perspective and view to the future

(2010) Margaret A. Liu   IMMUNOLOGICAL REVIEWS

Interferon regulatory factor-1 acts as a powerful adjuvant in tat DNA based vaccination

(2010) Arianna Castaldello et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations

(2010) A. D. Cristillo et al.   JOURNAL OF GENERAL VIROLOGY

Essential Role for TLR9 in Prime but Not Prime-Boost Plasmid DNA Vaccination To Activate Dendritic Cells and Protect from Lethal Viral Infection

(2010) D. Rottembourg et al.   JOURNAL OF IMMUNOLOGY

Coexpressed RIG-I Agonist Enhances Humoral Immune Response to Influenza Virus DNA Vaccine

(2010) J. M. Luke et al.   JOURNAL OF VIROLOGY

Down-regulation of Prdx6 contributes to DNA vaccine induced vitiligo in mice

(2010) Qi Zhou et al.   Molecular BioSystems

DAI (DLM-1/ZBP1) as a Genetic Adjuvant for DNA Vaccines That Promotes Effective Antitumor CTL Immunity

(2010) Alvaro Lladser et al.   MOLECULAR THERAPY

Minicircle DNA-based Gene Therapy Coupled With Immune Modulation Permits Long-term Expression of α-L-Iduronidase in Mice With Mucopolysaccharidosis Type I

(2010) Mark J Osborn et al.   MOLECULAR THERAPY

A robust system for production of minicircle DNA vectors

(2010) Mark A Kay et al.   NATURE BIOTECHNOLOGY

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Safety and Immunogenicity Study of Multiclade HIV-1 Adenoviral Vector Vaccine Alone or as Boost following a Multiclade HIV-1 DNA Vaccine in Africa

(2010) Walter Jaoko et al.   PLoS One

RNAi and small interfering RNAs in human disease therapeutic applications

(2010) Monica R. Lares et al.   TRENDS IN BIOTECHNOLOGY

Synergistic enhancement of immunogenicity and protection in mice against Schistosoma japonicum with codon optimization and electroporation delivery of SjTPI DNA vaccines

(2010) Yinchang Zhu et al.   VACCINE

A liposome-based platform, VacciMax®, and its modified water-free platform DepoVax™ enhance efficacy of in vivo nucleic acid delivery

(2010) Mohan Karkada et al.   VACCINE

Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection

(2010) Florence Faurez et al.   VACCINE

Enhancing immune responses against SARS-CoV nucleocapsid DNA vaccine by co-inoculating interleukin-2 expressing vector in mice

(2009) Hui Hu et al.   BIOTECHNOLOGY LETTERS

Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome

(2009) Kate Schroder et al.   CURRENT BIOLOGY

Plasmodium: Mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity

(2009) Carlota Dobaño et al.   EXPERIMENTAL PARASITOLOGY

Generation of High-Titer Neutralizing Antibodies against Botulinum Toxins A, B, and E by DNA Electrotransfer

(2009) C. Trollet et al.   INFECTION AND IMMUNITY

Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA–PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice

(2009) Maytal Bivas-Benita et al.   VACCINE

KMP-11 DNA immunization significantly protects against L. donovani infection but requires exogenous IL-12 as an adjuvant for comparable protection against L. major

(2009) Suniti Bhaumik et al.   VACCINE

DNA vaccines: developing new strategies to enhance immune responses

(2008) Shaheed A. Abdulhaqq et al.   IMMUNOLOGIC RESEARCH

A Nasal Interleukin-12 DNA Vaccine Coexpressing Yersinia pestis F1-V Fusion Protein Confers Protection against Pneumonic Plague

(2008) H. Yamanaka et al.   INFECTION AND IMMUNITY

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE

DNA vaccines: ready for prime time?

(2008) Michele A. Kutzler et al.   NATURE REVIEWS GENETICS