DNA vaccines, electroporation and their applications in cancer treatment

A loss of antitumor therapeutic activity of CEA DNA vaccines is associated with the lack of tumor cells' antigen presentation to Ag-specific CTLs in a colon cancer model

(2015) Euri Ahn et al.   CANCER LETTERS

MHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer That Is Reversed by Interferon and Selumetinib Treatment In Vitro

(2014) T. E. Angell et al.   CLINICAL CANCER RESEARCH

Alpha fetoprotein DNA prime and adenovirus boost immunization of two hepatocellular cancer patients

(2014) Lisa H Butterfield et al.   Journal of Translational Medicine

Combined Stimulation of IL-2 and 4-1BB Receptors Augments the Antitumor Activity of E7 DNA Vaccines by Increasing Ag-Specific CTL Responses

(2014) Ha Kim et al.   PLoS One

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response

(2014) P. Kvistborg et al.   Science Translational Medicine

Targeting regulatory T cells to improve vaccine immunogenicity in early life

(2014) Jorjoh Ndure et al.   Frontiers in Microbiology

Immunogenicity and Therapeutic Efficacy of a Dual-Component Genetic Cancer Vaccine Cotargeting Carcinoembryonic Antigen and HER2/neu in Preclinical Models

(2013) Luigi Aurisicchio et al.   HUMAN GENE THERAPY

Phase 1 studies of the safety and immunogenicity of electroporated HER2/CEA DNA vaccine followed by adenoviral boost immunization in patients with solid tumors

(2013) Claudia Marcela Diaz-Montero et al.   Journal of Translational Medicine

Xenogeneic Human p53 DNA Vaccination by Electroporation Breaks Immune Tolerance to Control Murine Tumors Expressing Mouse p53

(2013) Ruey-Shyang Soong et al.   PLoS One

Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques

(2013) Viraj Kulkarni et al.   Human Vaccines & Immunotherapeutics

Highly Optimized DNA Vaccine Targeting Human Telomerase Reverse Transcriptase Stimulates Potent Antitumor Immunity

(2013) J. Yan et al.   Cancer Immunology Research

DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8+ T-cell responses and increases PSA doubling time

(2012) Lindsey Chudley et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

DNA and adenovirus tumor vaccine expressing truncated survivin generates specific immune responses and anti-tumor effects in a murine melanoma model

(2012) Haihong Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Intratumoral electroporation of IL-12 cDNA eradicates established melanomas by Trp2180–188-specific CD8+ CTLs in a perforin/granzyme-mediated and IFN-γ-dependent manner: application of Trp2180–188 peptides

(2012) Jeong-Im Sin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Combined stimulation of TLR9 and 4.1BB augments Trp2 peptide vaccine-mediated melanoma rejection by increasing Ag-specific CTL activity and infiltration into tumor sites

(2012) Jeong-Im Sin et al.   CANCER LETTERS

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

(2012) M. L. Bagarazzi et al.   Science Translational Medicine

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Electroporation driven delivery of both an IL-12 expressing plasmid and cisplatin synergizes to inhibit B16 melanoma tumor growth through an NK cell mediated tumor killing mechanism

(2012) Ha Kim et al.   Human Vaccines & Immunotherapeutics

HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model

(2012) Tam Nguyen-Hoai et al.   OncoImmunology

Antitumor Therapeutic and Antimetastatic Activity of Electroporation-Delivered Human Papillomavirus 16 E7 DNA Vaccines: A Possible Mechanism for Enhanced Tumor Control

(2011) In Hee Lee et al.   DNA AND CELL BIOLOGY

Co-delivery of PSA and PSMA DNA vaccines with electroporation induces potent immune responses

(2011) Bernadette Ferraro et al.   Human vaccines & immunotherapeutics

A Phase 1 Study of a Vaccine Targeting Preferentially Expressed Antigen in Melanoma and Prostate-specific Membrane Antigen in Patients With Advanced Solid Tumors

(2011) Jeffrey S. Weber et al.   JOURNAL OF IMMUNOTHERAPY

Antigen specificity of immune suppression by myeloid-derived suppressor cells

(2011) S. Solito et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The use of layered double hydroxides as DNA vaccine delivery vector for enhancement of anti-melanoma immune response

(2010) Ang Li et al.   BIOMATERIALS

DNA Vaccines against Infectious Diseases and Cancer

(2010) Duk-Jae Han et al.   Biomolecules & Therapeutics

Molecular Mechanism of MART-1 + /A*0201 + Human Melanoma Resistance to Specific CTL-Killing Despite Functional Tumor–CTL Interaction

(2010) Ali R. Jazirehi et al.   CANCER RESEARCH

DNA Vaccine Encoding Prostatic Acid Phosphatase (PAP) Elicits Long-term T-cell Responses in Patients With Recurrent Prostate Cancer

(2010) Jordan T. Becker et al.   JOURNAL OF IMMUNOTHERAPY

Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial

(2010) Håkan Norell et al.   Journal of Translational Medicine

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccine site inflammation potentiates idiotype DNA vaccine-induced therapeutic T cell-, and not B cell-, dependent antilymphoma immunity

(2009) H. Qin et al.   BLOOD

Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer

(2009) Aaron S Mansfield et al.   BMC CANCER

Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists

(2009) K. S. Peggs et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells

(2009) S. Gnjatic et al.   CLINICAL CANCER RESEARCH

DNA Vaccination with Electroporation Induces Increased Antibody Responses in Patients with Prostate Cancer

(2009) Lindsey Low et al.   HUMAN GENE THERAPY

Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections

(2009) Tsvetelina Pentcheva-Hoang et al.   IMMUNOLOGICAL REVIEWS

Suppression of antitumour protective cytotoxic T lymphocyte responses to a human papillomavirus 16 E7 DNA vaccine by coinjection of interleukin-12 complementary DNA: involvement of nitric oxide in immune suppression

(2009) Jeong-Im Sin   IMMUNOLOGY

Safety and Immunological Efficacy of a DNA Vaccine Encoding Prostatic Acid Phosphatase in Patients With Stage D0 Prostate Cancer

(2009) Douglas G. McNeel et al.   JOURNAL OF CLINICAL ONCOLOGY

Adoptive Transfer of Human Papillomavirus E7-specific CTL Enhances Tumor Chemoresponse Through the Perforin/Granzyme-mediated Pathway

(2009) Jeong-Im Sin et al.   MOLECULAR THERAPY

Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery

(2009) Simon R. Best et al.   VACCINE

DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance

(2008) C. Chaise et al.   BLOOD

A Phase I Trial of a Human Papillomavirus DNA Vaccine for HPV16+ Cervical Intraepithelial Neoplasia 2/3

(2008) C. L. Trimble et al.   CLINICAL CANCER RESEARCH

GMP production of pDERMATT for vaccination against melanoma in a phase I clinical trial

(2008) S.G.L. Quaak et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Phenotypic and Functional Analysis of Dendritic Cells and Clinical Outcome in Patients With High-Risk Melanoma Treated With Adjuvant Granulocyte Macrophage Colony-Stimulating Factor

(2008) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase 1 Trial of Intranodal Injection of a Melan-A/MART-1 DNA Plasmid Vaccine in Patients With Stage IV Melanoma

(2008) Jeffrey Weber et al.   JOURNAL OF IMMUNOTHERAPY

Phase I/II Study of GM-CSF DNA as an Adjuvant for a Multipeptide Cancer Vaccine in Patients With Advanced Melanoma

(2008) Miguel-Angel Perales et al.   MOLECULAR THERAPY

Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen

(2008) Jian Yan et al.   VACCINE