Technologies for enhanced efficacy of DNA vaccines

Novel Strategies to Improve DNA Vaccine Immunogenicity

(2011) Cevayir Coban et al.   CURRENT GENE THERAPY

Electroporation delivery of DNA vaccines: prospects for success

(2011) Niranjan Y Sardesai et al.   CURRENT OPINION IN IMMUNOLOGY

Carbohydrate-based immune adjuvants

(2011) Nikolai Petrovsky et al.   Expert Review of Vaccines

Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination

(2011) P Fagone et al.   GENE THERAPY

Molecular and cellular mechanisms of DNA vaccines

(2011) Cevayir Coban et al.   Human vaccines & immunotherapeutics

Genetic immunization: Bacteria as DNA vaccine delivery vehicles

(2011) Pablo Daniel Becker et al.   Human vaccines & immunotherapeutics

The Vaccine Renaissance

(2011) Nikolai Petrovsky   Human vaccines & immunotherapeutics

Long-Term Control of Simian Immunodeficiency Virusmac251 Viremia to Undetectable Levels in Half of Infected Female Rhesus Macaques Nasally Vaccinated with Simian Immunodeficiency Virus DNA/Recombinant Modified Vaccinia Virus Ankara

(2011) M. Manrique et al.   JOURNAL OF IMMUNOLOGY

Essential role of high-mobility group box proteins in nucleic acid-mediated innate immune responses

(2011) H. Yanai et al.   JOURNAL OF INTERNAL MEDICINE

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Alum's adjuvant action: grease is the word

(2011) M Lamine Mbow et al.   NATURE MEDICINE

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Co-Administration of a Plasmid DNA Encoding IL-15 Improves Long-Term Protection of a Genetic Vaccine against Trypanosoma cruzi

(2011) Christopher S. Eickhoff et al.   PLoS Neglected Tropical Diseases

Enhanced potency of individual and bivalent DNA replicon vaccines or conventional DNA vaccines by formulation with aluminum phosphate

(2010) Yun-Zhou Yu et al.   BIOLOGICALS

IL-15 increases the frequency of effector memory CD8+ T cells in rhesus monkeys immunized with HIV vaccine

(2010) Shirui Li et al.   Cellular & Molecular Immunology

Vaccination of chickens with DNA vaccine encoding Eimeria acervulina 3-1E and chicken IL-15 offers protection against homologous challenge

(2010) Dexing Ma et al.   EXPERIMENTAL PARASITOLOGY

Electroporation for DNA immunization: clinical application

(2010) Sylvia van Drunen Littel-van den Hurk et al.   Expert Review of Vaccines

Potent Antirheumatic Activity of a New DNA Vaccine Targeted to B7-2/CD28 Costimulatory Signaling Pathway in Autoimmune Arthritis

(2010) Hong Xue et al.   HUMAN GENE THERAPY

Prime-boost vectored malaria vaccines: Progress and prospects

(2010) Adrian V. S. Hill et al.   Human vaccines & immunotherapeutics

Mucosal and systemic anti-GAG immunity induced by neonatal immunization with HIV LAMP/gag DNA vaccine in mice

(2010) Adriana Letícia Goldoni et al.   IMMUNOBIOLOGY

The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA

(2010) Peter Öhlschläger et al.   INTERNATIONAL JOURNAL OF CANCER

Enhancement of DNA vaccine potency by antigen linkage to IFN-γ-inducible protein-10

(2010) Tae Heung Kang et al.   INTERNATIONAL JOURNAL OF CANCER

Interferon regulatory factor-1 acts as a powerful adjuvant in tat DNA based vaccination

(2010) Arianna Castaldello et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses

(2010) M. Lobigs et al.   JOURNAL OF GENERAL VIROLOGY

Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations

(2010) A. D. Cristillo et al.   JOURNAL OF GENERAL VIROLOGY

Essential Role for TLR9 in Prime but Not Prime-Boost Plasmid DNA Vaccination To Activate Dendritic Cells and Protect from Lethal Viral Infection

(2010) D. Rottembourg et al.   JOURNAL OF IMMUNOLOGY

A Phase 1/2 Study of a Multiclade HIV‐1 DNA Plasmid Prime and Recombinant Adenovirus Serotype 5 Boost Vaccine in HIV‐Uninfected East Africans (RV 172)

(2010) Hannah Kibuuka et al.   JOURNAL OF INFECTIOUS DISEASES

Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial

(2010) Håkan Norell et al.   Journal of Translational Medicine

Intranasal DNA Vaccination Induces Potent Mucosal and Systemic Immune Responses and Cross-protective Immunity Against Influenza Viruses

(2010) Lea Torrieri-Dramard et al.   MOLECULAR THERAPY

The impact of intragenic CpG content on gene expression

(2010) Asli Petra Bauer et al.   NUCLEIC ACIDS RESEARCH

GM-CSF Increases Mucosal and Systemic Immunogenicity of an H1N1 Influenza DNA Vaccine Administered into the Epidermis of Non-Human Primates

(2010) Peter T. Loudon et al.   PLoS One

Safety and Immunogenicity Study of Multiclade HIV-1 Adenoviral Vector Vaccine Alone or as Boost following a Multiclade HIV-1 DNA Vaccine in Africa

(2010) Walter Jaoko et al.   PLoS One

Immunogenic characterization and protection against Streptococcus mutans infection induced by intranasal DNA prime–protein boost immunization

(2010) Yu Hong Li et al.   VACCINE

Liposomal oral DNA vaccine (mycobacterium DNA) elicits immune response

(2010) Danan Wang et al.   VACCINE

A liposome-based platform, VacciMax®, and its modified water-free platform DepoVax™ enhance efficacy of in vivo nucleic acid delivery

(2010) Mohan Karkada et al.   VACCINE

An IL-15 adjuvant enhances the efficacy of a combined DNA vaccine against Brucella by increasing the CD8+ cytotoxic T cell response

(2010) Xi-Dan Hu et al.   VACCINE

Construction of an HBV DNA vaccine by fusion of the GM-CSF gene to the HBV-S gene and examination of its immune effects in normal and HBV-transgenic mice

(2010) Yuling Qing et al.   VACCINE

In vivo electroporation enhances the potency of poly-lactide co-glycolide (PLG) plasmid DNA immunization

(2010) Christine M. Barbon et al.   VACCINE

Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection

(2010) Florence Faurez et al.   VACCINE

Biodistribution, persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporation

(2010) Andreas Bråve et al.   VACCINE

Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin

(2010) Larry R. Smith et al.   VACCINE

The introduction of multi-copy CpG motifs into an antiviral DNA vaccine strongly up-regulates its immunogenicity in fish

(2010) S. Martinez-Alonso et al.   VACCINE

The Toll-like receptor adaptor molecule TRIF enhances DNA vaccination against classical swine fever

(2010) Chao Wan et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Delivery of DNA vaccines: an overview on the use of biodegradable polymeric and magnetic nanoparticles

(2010) Sue D. Xiang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Plasmid DNA vaccine vector design: Impact on efficacy, safety and upstream production

(2009) James A. Williams et al.   BIOTECHNOLOGY ADVANCES

Enhancing immune responses against SARS-CoV nucleocapsid DNA vaccine by co-inoculating interleukin-2 expressing vector in mice

(2009) Hui Hu et al.   BIOTECHNOLOGY LETTERS

Intracellular detection and immune signaling pathways of DNA vaccines

(2009) Choon-Kit Tang et al.   Expert Review of Vaccines

Genetic heterologous prime–boost vaccination strategies for improved systemic and mucosal immunity

(2009) Charani Ranasinghe et al.   Expert Review of Vaccines

Innate immune control of nucleic acid-based vaccine immunogenicity

(2009) Shohei Koyama et al.   Expert Review of Vaccines

DNA Vaccination with Electroporation Induces Increased Antibody Responses in Patients with Prostate Cancer

(2009) Lindsey Low et al.   HUMAN GENE THERAPY

Persistent Immune Responses Induced by a Human Immunodeficiency Virus DNA Vaccine Delivered in Association with Electroporation in the Skin of Nonhuman Primates

(2009) Frédéric Martinon et al.   HUMAN GENE THERAPY

Suppression of antitumour protective cytotoxic T lymphocyte responses to a human papillomavirus 16 E7 DNA vaccine by coinjection of interleukin-12 complementary DNA: involvement of nitric oxide in immune suppression

(2009) Jeong-Im Sin   IMMUNOLOGY

Co-immunization with an optimized plasmid-encoded immune stimulatory interleukin, high-mobility group box 1 protein, results in enhanced interferon-γ secretion by antigen-specific CD8 T cells

(2009) Gowtham Muthumani et al.   IMMUNOLOGY

Lipopolysaccharide contamination in intradermal DNA vaccination: Toxic impurity or adjuvant?

(2009) Joost H. van den Berg et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination

(2009) Hanqian Xu et al.   JOURNAL OF GENE MEDICINE

Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccination

(2009) M Manrique et al.   Mucosal Immunology

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Use of B7 costimulatory molecules as adjuvants in a prime-boost vaccination against Visna/Maedi ovine lentivirus

(2009) X. de Andrés et al.   VACCINE

Multimeric soluble CD40 ligand (sCD40L) efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus vectors MVA and NYVAC expressing HIV antigens

(2009) Carmen E. Gómez et al.   VACCINE

KMP-11 DNA immunization significantly protects against L. donovani infection but requires exogenous IL-12 as an adjuvant for comparable protection against L. major

(2009) Suniti Bhaumik et al.   VACCINE

Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques

(2009) Brian D. Livingston et al.   VACCINE

FDA guidance on prophylactic DNA vaccines: Analysis and recommendations

(2009) Dennis M. Klinman et al.   VACCINE

Use of Vaxfectin Adjuvant with DNA Vaccine Encoding the Measles Virus Hemagglutinin and Fusion Proteins Protects Juvenile and Infant Rhesus Macaques against Measles Virus

(2008) C.-H. Pan et al.   Clinical and Vaccine Immunology

DNA Vaccines Targeting Tumor Antigens to B7 Molecules on Antigen-Presenting Cells Induce Protective Antitumor Immunity and Delay Onset of HER-2/Neu-Driven Mammary Carcinoma

(2008) A. Sloots et al.   CLINICAL CANCER RESEARCH

Comparison of cholera toxin A2/B and murine interleukin-12 as adjuvants of Toxoplasma multi-antigenic SAG1-ROP2 DNA vaccine

(2008) Mingfu Xue et al.   EXPERIMENTAL PARASITOLOGY

Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration

(2008) Pieranna Chiarella et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Freeing vaccine adjuvants from dangerous immunological dogma

(2008) Nikolai Petrovsky   Expert Review of Vaccines

Genetic co-transfer of CCR7 ligands enhances immunity and prolongs survival against virulent challenge of pseudorabies virus

(2008) Young Woo Han et al.   IMMUNOLOGY AND CELL BIOLOGY

A Nasal Interleukin-12 DNA Vaccine Coexpressing Yersinia pestis F1-V Fusion Protein Confers Protection against Pneumonic Plague

(2008) H. Yamanaka et al.   INFECTION AND IMMUNITY

Phenotypic and Functional Analysis of Dendritic Cells and Clinical Outcome in Patients With High-Risk Melanoma Treated With Adjuvant Granulocyte Macrophage Colony-Stimulating Factor

(2008) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses

(2008) Alexandre Harari et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA gag/Adenovirus Type 5 (Ad5) gag and Ad5 gag/Ad5 gag Vaccines Induce Distinct T-Cell Response Profiles

(2008) K. S. Cox et al.   JOURNAL OF VIROLOGY

Phase I/II Study of GM-CSF DNA as an Adjuvant for a Multipeptide Cancer Vaccine in Patients With Advanced Melanoma

(2008) Miguel-Angel Perales et al.   MOLECULAR THERAPY

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE

DNA vaccines: ready for prime time?

(2008) Michele A. Kutzler et al.   NATURE REVIEWS GENETICS

Protective effect of a multiantigenic DNA vaccine against Toxoplasma gondii with co-delivery of IL-12 in mice

(2008) Y.-L. CUI et al.   PARASITE IMMUNOLOGY

The enhanced anti-angiogenic and antitumor effects of combining flk1-based DNA vaccine and IP-10

(2008) Xiao-ling Lu et al.   VACCINE

Heterologous HA DNA vaccine prime—inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses

(2008) Shixia Wang et al.   VACCINE

Efficient augmentation of a long-lasting immune responses in HIV-1 gag DNA vaccination by IL-15 plasmid boosting

(2008) Wenjing Li et al.   VACCINE

Enhancement of neutralizing humoral response of DNA vaccine against duck hepatitis B virus envelope protein by co-delivery of cytokine genes

(2008) Fadi Saade et al.   VACCINE

IL-15 as memory T-cell adjuvant for topical HIV-1 DermaVir vaccine

(2008) Sandra A. Calarota et al.   VACCINE

Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus

(2008) Xiao Wang et al.   VACCINE

Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation

(2008) Margherita Rosati et al.   VACCINE

DNA fusion vaccines incorporating IL-23 or RANTES for use in immunization against influenza

(2008) J. Williman et al.   VACCINE

Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques

(2008) Lauren A. Hirao et al.   VACCINE

The Opposing Effects of Lipopolysaccharide on the Antitumor Therapeutic Efficacy of DNA Vaccine

(2007) Chi-Chen Lin et al.   DNA AND CELL BIOLOGY

Plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B

(2007) Kapil Khatri et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques

(2007) Lauren A. Hirao et al.   VACCINE