Deubiquitinases (DUBs) and DUB inhibitors: a patent review

DUBs, the regulation of cell identity and disease

(2015) Johanna Heideker et al.   BIOCHEMICAL JOURNAL

Deubiquitinases and the new therapeutic opportunities offered to cancer

(2015) R. Pfoh et al.   ENDOCRINE-RELATED CANCER

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

The Human Otubain2-Ubiquitin Structure Provides Insights into the Cleavage Specificity of Poly-Ubiquitin-Linkages

(2015) Mikael Altun et al.   PLoS One

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

(2015) Ningning Liu et al.   Oncotarget

The deubiquitinase A20 in immunopathology of autoimmune diseases

(2014) Ishani Majumdar et al.   AUTOIMMUNITY

Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia

(2014) W. Fiskus et al.   CANCER RESEARCH

Deubiquitinating Enzyme Inhibitors and their Potential in Cancer Therapy

(2014) Bernat Crosas   CURRENT CANCER DRUG TARGETS

Overview of Proteasome Inhibitor-Based Anti-cancer Therapies: Perspective on Bortezomib and Second Generation Proteasome Inhibitors versus Future Generation Inhibitors of Ubiquitin-Proteasome System

(2014) Q. Dou et al.   CURRENT CANCER DRUG TARGETS

NMR Spectroscopy-Based Metabolic Profiling of Drug-Induced Changes In Vitro Can Discriminate between Pharmacological Classes

(2014) Obaid Aftab et al.   Journal of Chemical Information and Modeling

Linear ubiquitin chains: NF-κB signalling, cell death and beyond

(2014) Kazuhiro Iwai et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web

(2014) Nikolaus Fortelny et al.   PLOS BIOLOGY

Ubiquitin pathways in neurodegenerative disease

(2014) Graham Atkin et al.   Frontiers in Molecular Neuroscience

Mechanisms of Generating Polyubiquitin Chains of Different Topology

(2014) Randy Suryadinata et al.   Cells

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

(2013) Slavica Brnjic et al.   ANTIOXIDANTS & REDOX SIGNALING

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

(2013) Lan K Nguyen et al.   Cell Communication and Signaling

USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer

(2013) S. Byun et al.   CLINICAL CANCER RESEARCH

From Bortezomib to other Inhibitors of the Proteasome and Beyond

(2013) Daniela Buac et al.   CURRENT PHARMACEUTICAL DESIGN

Deubiquitinating Enzymes as Therapeutic Targets in Cancer

(2013) Key-Hwan Lim et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting the ubiquitin–proteasome system for cancer therapy

(2013) Min Shen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia

(2013) D Koyama et al.   LEUKEMIA

Usp16 contributes to somatic stem-cell defects in Down’s syndrome

(2013) Maddalena Adorno et al.   NATURE

UCHL1 S18Y variant is a risk factor for Parkinson’s disease in Japan

(2012) Yoshihiro Miyake et al.   BMC Neurology

Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma

(2012) Yanjie Chen et al.   DIGESTIVE DISEASES AND SCIENCES

New targeted approaches against the ubiquitin–proteasome system in gastrointestinal malignancies

(2012) Enrique Grande et al.   Expert Review of Anticancer Therapy

Proteasome deubiquitinases as novel targets for cancer therapy

(2012) Pádraig D’Arcy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modification by Ubiquitin-Like Proteins: Significance in Apoptosis and Autophagy Pathways

(2012) Umar-Faruq Cajee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells

(2012) Zdenek Skrott et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis

(2012) Armin M. Gamper et al.   MOLECULAR CELL

The hallmarks of cancer

(2012) Tony Gutschner et al.   RNA Biology

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Antiviral Activity of a Small Molecule Deubiquitinase Inhibitor Occurs via Induction of the Unfolded Protein Response

(2012) Jeffrey W. Perry et al.   PLoS Pathogens

Intrinsic Protein Kinase Activity in Mitochondrial Oxidative Phosphorylation Complexes

(2011) Darci Phillips et al.   BIOCHEMISTRY

Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials

(2011) B. C. Potts et al.   CURRENT CANCER DRUG TARGETS

Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

(2011) Tushar K. Maiti et al.   FEBS Journal

Metal complexes as inhibitors of the 26S proteasome in tumor cells

(2011) Cláudio N. Verani   JOURNAL OF INORGANIC BIOCHEMISTRY

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

Toward understanding Machado–Joseph disease

(2011) Maria do Carmo Costa et al.   PROGRESS IN NEUROBIOLOGY

The therapeutic potential of deubiquitinating enzyme inhibitors

(2010) Frédéric Colland   BIOCHEMICAL SOCIETY TRANSACTIONS

Chaperone-assisted assembly of the proteasome core particle

(2010) Ana C. Matias et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A new map to understand deubiquitination: Table 1

(2010) Elijah J. Katz et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Deubiquitinases in the regulation of NF-κB signaling

(2010) Edward W Harhaj et al.   CELL RESEARCH

The role of deubiquitinating enzymes in chromatin regulation

(2010) Boyko S. Atanassov et al.   FEBS LETTERS

Association Between the Ubiquitin Carboxyl-Terminal Esterase L1 Gene (UCHL1) S18Y Variant and Parkinson's Disease: A HuGE Review and Meta-Analysis

(2009) M. Ragland et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

The ubiquitin proteasome system and its involvement in cell death pathways

(2009) F Bernassola et al.   CELL DEATH AND DIFFERENTIATION

DUBs at a glance

(2009) K. D. Wilkinson   JOURNAL OF CELL SCIENCE

Ubiquitinated Proteins Activate the Proteasome by Binding to Usp14/Ubp6, which Causes 20S Gate Opening

(2009) Andreas Peth et al.   MOLECULAR CELL

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles

(2008) Mariola J. Edelmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

(2008) Natalia B. Nedelsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

IFN-  and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis

(2008) G. B. Lesinski et al.   CANCER RESEARCH

Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation

(2008) Marjelo A. Mines et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ni(II), Cu(II), and Zn(II) Diethyldithiocarbamate Complexes Show Various Activities Against the Proteasome in Breast Cancer Cells

(2008) Boris Cvek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity

(2008) Vesna Milacic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY