A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma

(2013) Chungyee Leung-Hagesteijn et al.   CANCER CELL

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

(2012) Y.-T. Tai et al.   BLOOD

Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells

(2012) Z. Tian et al.   BLOOD

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme

(2012) Céline Reverdy et al.   CHEMISTRY & BIOLOGY

Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma

(2012) Yanjie Chen et al.   DIGESTIVE DISEASES AND SCIENCES

Proteasome deubiquitinases as novel targets for cancer therapy

(2012) Pádraig D’Arcy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

New Proteasome Inhibitors in Myeloma

(2012) Panisinee Lawasut et al.   Current Hematologic Malignancy Reports

DUBs and cancer: The role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

(2011) Sajjad Hussain et al.   CELL CYCLE

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

(2011) Dharminder Chauhan et al.   CLINICAL CANCER RESEARCH

Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

(2011) Tushar K. Maiti et al.   FEBS Journal

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

The therapeutic potential of deubiquitinating enzyme inhibitors

(2010) Frédéric Colland   BIOCHEMICAL SOCIETY TRANSACTIONS

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Regulators of the Proteasome Pathway, Uch37 and Rpn13, Play Distinct Roles in Mouse Development

(2010) Amin Al-Shami et al.   PLoS One

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Reverse the curse—the role of deubiquitination in cell cycle control

(2008) Ling Song et al.   CURRENT OPINION IN CELL BIOLOGY

AIP1 Is Critical in Transducing IRE1-mediated Endoplasmic Reticulum Stress Response

(2008) Dianhong Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation

(2008) Marjelo A. Mines et al.   JOURNAL OF BIOLOGICAL CHEMISTRY