Developmental origins of non-alcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease

Liver fat accumulation as a barometer of insulin responsiveness again points to adipose tissue as the culprit

(2017) Yaron Rotman et al.   HEPATOLOGY

Synergistic Interaction of Hypertension and Diabetes in Promoting Kidney Injury and the Role of Endoplasmic Reticulum StressNovelty and Significance

(2017) Zhen Wang et al.   HYPERTENSION

Severity of nonalcoholic fatty liver disease on sonography and risk of coronary heart disease

(2017) Sun Hwa Lee et al.   JOURNAL OF CLINICAL ULTRASOUND

The impact of IUGR on pancreatic islet development and β-cell function

(2017) Brit H Boehmer et al.   JOURNAL OF ENDOCRINOLOGY

Effects of delta-tocotrienol on obesity-related adipocyte hypertrophy, inflammation and hepatic steatosis in high-fat-fed mice

(2017) London Allen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

(2017) Kimberly P. Newton et al.   JOURNAL OF PEDIATRICS

A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice

(2017) Michael Kruse et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations

(2017) Umesh D. Wankhade et al.   PLoS One

XBP1-FoxO1 interaction regulates ER stress-induced autophagy in auditory cells

(2017) Akihiro Kishino et al.   Scientific Reports

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

Treatment of patients with type 2 diabetes and non-alcoholic fatty liver disease: current approaches and future directions

(2016) Kenneth Cusi   DIABETOLOGIA

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

Enhanced Steatosis and Fibrosis in Liver of Adult Offspring Exposed to Maternal High-Fat Diet

(2016) Michael D. Thompson et al.   GENE EXPRESSION

Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: The multiethnic cohort

(2016) Veronica Wendy Setiawan et al.   HEPATOLOGY

Placental Growth Factor Administration Abolishes Placental Ischemia-Induced HypertensionNovelty and Significance

(2016) Frank T. Spradley et al.   HYPERTENSION

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy

(2016) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

Fatty Acid de Novo Synthesis in Adult Intrauterine Growth-Restricted Offspring, and Adult Male Response to a High Fat Diet

(2016) Jennifer K. Yee et al.   LIPIDS

Non-alcoholic fatty liver disease and diabetes

(2016) Jonathan M. Hazlehurst et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and −10 in spontaneously hypertensive rats with steatohepatitis

(2016) Masaya Kozono et al.   Molecular Medicine Reports

Chronic Protein Restriction in Mice Impacts Placental Function and Maternal Body Weight before Fetal Growth

(2016) Paula N. Gonzalez et al.   PLoS One

Increased susceptibility of prenatal food restricted offspring to high-fat diet-induced nonalcoholic fatty liver disease is intrauterine programmed

(2016) Li Zhang et al.   REPRODUCTIVE TOXICOLOGY

Adipose Snail1 Regulates Lipolysis and Lipid Partitioning by Suppressing Adipose Triacylglycerol Lipase Expression

(2016) Chengxin Sun et al.   Cell Reports

Prevalence of Prediabetes and Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease

(2016) Kimberly P. Newton et al.   JAMA Pediatrics

Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death

(2015) Constance Ahowesso et al.   BIOCHEMICAL PHARMACOLOGY

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Dipeptidyl Peptidase-4 Inhibition Ameliorates Western Diet–Induced Hepatic Steatosis and Insulin Resistance Through Hepatic Lipid Remodeling and Modulation of Hepatic Mitochondrial Function

(2015) Annayya R. Aroor et al.   DIABETES

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

(2015) Romy Kursawe et al.   DIABETES

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

HepaticXbp1Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and Apoptosis

(2015) Shantel Olivares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus and Normal Plasma Aminotransferase Levels

(2015) Paola Portillo-Sanchez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The predictive value of the uterine artery pulsatility index during the early third trimester for the occurrence of adverse pregnancy outcomes depending on the maternal obesity

(2015) Yeon Hee Kim et al.   Obesity Research & Clinical Practice

High protein intake in neonatal period induces glomerular hypertrophy and sclerosis in adulthood in rats born with IUGR

(2015) Farid Boubred et al.   PEDIATRIC RESEARCH

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids

(2015) Daniel F. Vatner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress

(2015) Keiko Muramatsu-Kato et al.   Scientific Reports

Maternal Nutrient Restriction Alters Ca2+ Handling Properties and Contractile Function of Isolated Left Ventricle Bundles in Male But Not Female Juvenile Rats

(2015) Thomas J. Harvey et al.   PLoS One

Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury

(2015) Bhavya B. Chandrika et al.   PLoS One

Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammation

(2014) Victoria Catalán et al.   ACTA DIABETOLOGICA

Neutralizing Th2 Inflammation in Neonatal Islets Prevents β-Cell Failure in Adult IUGR Rats

(2014) Lane J. Jaeckle Santos et al.   DIABETES

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Metformin treatment to reduce central adiposity after prenatal growth restraint: a placebo-controlled pilot study in prepubertal children

(2014) Marta Díaz et al.   PEDIATRIC DIABETES

Peroxisome Proliferator-Activated Receptor α Activation Induces Hepatic Steatosis, Suggesting an Adverse Effect

(2014) Fang Yan et al.   PLoS One

Adipocyte Hypertrophy, Inflammation and Fibrosis Characterize Subcutaneous Adipose Tissue of Healthy, Non-Obese Subjects Predisposed to Type 2 Diabetes

(2014) A. M. Josefin Henninger et al.   PLoS One

Prenatal Exposure to Hypoxia Induced Beclin 1 Signaling-Mediated Renal Autophagy and Altered Renal Development in Rat Fetuses

(2014) Shuixiu Xia et al.   Reproductive Sciences

Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease

(2014) Ken-ichiro Kato et al.   Journal of Diabetes Investigation

Cohort Study of Non-alcoholic Fatty Liver Disease, NAFLD fibrosis score and the Risk of Incident Diabetes in a Korean population

(2013) Yoosoo Chang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Placental Vascular Dysfunction, Fetal and Childhood Growth, and Cardiovascular Development

(2013) Romy Gaillard et al.   CIRCULATION

Nonalcoholic Fatty Liver Disease in Prepubertal Children Born Small for Gestational Age: Influence of Rapid Weight Catch-Up Growth

(2013) Maria Felicia Faienza et al.   Hormone Research in Paediatrics

Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype

(2013) Geoffrey C. Farrell et al.   LIVER INTERNATIONAL

Surgical assessment of significant steatosis in donor livers: The beginning of the end for frozen-section analysis?

(2013) Elizabeth M. Brunt   LIVER TRANSPLANTATION

The Long-term impact of intrauterine growth restriction in a diverse US cohort of children: The EPOCH study

(2013) Tessa L. Crume et al.   Obesity

Effect of Prenatal Hypoxia in Transgenic Mouse Models of Preeclampsia and Fetal Growth Restriction

(2013) C. F. Rueda-Clausen et al.   Reproductive Sciences

What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?

(2013) Carmine Finelli   WORLD JOURNAL OF GASTROENTEROLOGY

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

(2013) Melania Gaggini et al.   Nutrients

Developmental programming of neonatal pancreatic β-cells by a maternal low-protein diet in rats involves a switch from proliferation to differentiation

(2012) Adriana Rodríguez-Trejo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sex-Dependent Programming of Glucose and Fatty Acid Metabolism in Mouse Offspring by Maternal Protein Restriction

(2012) Esther M.E. van Straten et al.   Gender Medicine

Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model*

(2012) Marcela Aparicio-Vergara et al.   HEPATOLOGY

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

(2011) Motoharu Awazawa et al.   Cell Metabolism

Maternal High-Fat Diet Disturbs Uteroplacental Hemodynamics and Increases the Frequency of Stillbirth in a Nonhuman Primate Model of Excess Nutrition

(2011) Antonio E. Frias et al.   ENDOCRINOLOGY

Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children

(2011) Anna Alisi et al.   International Journal of Endocrinology

Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus

(2010) Vera S. G. Ferreira et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

(2010) F. K. Huynh et al.   DIABETES

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Increased Soluble Leptin Receptor Levels in Morbidly Obese Patients With Insulin Resistance and Nonalcoholic Fatty Liver Disease

(2010) Valentina Medici et al.   Obesity

Presence of Coronary Plaques in Patients with Nonalcoholic Fatty Liver Disease

(2010) Nimer Assy et al.   RADIOLOGY

Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance

(2010) Jan Mauer et al.   PLoS Genetics

Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats

(2009) Elisabeth L. Raab et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fetuses of Obese Mothers Develop Insulin Resistance in Utero

(2009) P. M. Catalano et al.   DIABETES CARE

Intrauterine Growth Restriction Increases Fetal Hepatic Gluconeogenic Capacity and Reduces Messenger Ribonucleic Acid Translation Initiation and Nutrient Sensing in Fetal Liver and Skeletal Muscle

(2009) Stephanie R. Thorn et al.   ENDOCRINOLOGY

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family

(2008) H M Heath-Engel et al.   ONCOGENE