The impact of IUGR on pancreatic islet development and β-cell function

RNA Sequencing Exposes Adaptive and Immune Responses to Intrauterine Growth Restriction in Fetal Sheep Islets

(2017) Amy C. Kelly et al.   ENDOCRINOLOGY

Differential performance of first-trimester screening in predicting small-for-gestational-age neonate or fetal growth restriction

(2017) F. Crovetto et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Peri- and Postnatal Effects of Prenatal Adenoviral VEGF Gene Therapy in Growth-Restricted Sheep1

(2016) David J. Carr et al.   BIOLOGY OF REPRODUCTION

Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep

(2016) Laura D. Brown et al.   ENDOCRINOLOGY

Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction

(2016) Antoni R. Macko et al.   ENDOCRINOLOGY

Detection of expressional changes induced by intrauterine growth restriction in the developing rat pancreas

(2016) Lin Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Maternal Administration of Sildenafil Citrate Alters Fetal and Placental Growth and Fetal–Placental Vascular Resistance in the Growth-Restricted Ovine FetusNovelty and Significance

(2016) Charlotte Oyston et al.   HYPERTENSION

Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine

(2016) Xiaochuan Chen et al.   JOURNAL OF ENDOCRINOLOGY

The global gene expression profile of the secondary transition during pancreatic development

(2016) Stefanie J. Willmann et al.   MECHANISMS OF DEVELOPMENT

Pancreatic islet hepatocyte growth factor and vascular endothelial growth factor A signaling in growth restricted fetuses

(2016) Paul J. Rozance et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age

(2016) Philip G. Murray et al.   PEDIATRIC RESEARCH

Effect of insulin-like growth factor-I during the early postnatal period in intrauterine growth-restricted rats

(2016) Naho Ikeda et al.   PEDIATRICS INTERNATIONAL

Intrauterine Growth Restriction: Hungry for an Answer

(2016) Sherin U. Devaskar et al.   PHYSIOLOGY

Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis

(2016) Leonid E. Fridlyand et al.   PLoS One

Effect of placental restriction and neonatal exendin-4 treatment on postnatal growth, adult body composition, and in vivo glucose metabolism in the sheep

(2015) Hong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Human pancreas development

(2015) R. E. Jennings et al.   DEVELOPMENT

Increased Adrenergic Signaling Is Responsible for Decreased Glucose-Stimulated Insulin Secretion in the Chronically Hyperinsulinemic Ovine Fetus

(2015) Sasha E. Andrews et al.   ENDOCRINOLOGY

Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells

(2015) Karel A. Erion et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Sensitivity and Secretory Response in Adults Born Preterm: The Helsinki Study of Very Low Birth Weight Adults

(2015) Eero Kajantie et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Approaches to Reducing Radiation Dose from Radionuclide Myocardial Perfusion Imaging

(2015) S. Dorbala et al.   JOURNAL OF NUCLEAR MEDICINE

A Synthetic Heterobivalent Ligand Composed of Glucagon-Like Peptide 1 and Yohimbine Specifically Targets β Cells Within the Pancreas

(2015) Leah V. Steyn et al.   MOLECULAR IMAGING AND BIOLOGY

Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line

(2015) Lotta E. Andersson et al.   PLoS One

Islet Inflammation, Hemosiderosis, and Fibrosis in Intrauterine Growth-Restricted and High Fat-Fed Sprague-Dawley Rats

(2014) Viviane Delghingaro-Augusto et al.   AMERICAN JOURNAL OF PATHOLOGY

Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep

(2014) Paul J. Rozance et al.   DIABETES

Featured Article: Beta cell specific pyruvate dehydrogenase alpha gene deletion results in a reduced islet number and β-cell mass postnatally

(2014) Mulchand S Patel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nutrient regulation of insulin secretion and action

(2014) Philip Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Local Over-Expression of VEGF-DΔNΔC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis

(2014) Vedanta Mehta et al.   PLoS One

SGA Children with Moderate Catch-Up Growth Are Showing the Impaired Insulin Secretion at the Age of 4

(2014) Ivana Milovanovic et al.   PLoS One

Revealing transcription factors during human pancreatic β cell development

(2014) Elizabeth Conrad et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency

(2013) Sean W. Limesand et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep

(2013) Xiaochuan Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Clinical and molecular characterisation of hyperinsulinaemic hypoglycaemia in infants born small-for-gestational age

(2013) Ved Bhushan Arya et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta-analysis

(2013) A Conde-Agudelo et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

(2013) R. B. Reinert et al.   DIABETES

Chronic High Glucose and Pyruvate Levels Differentially Affect Mitochondrial Bioenergetics and Fuel-stimulated Insulin Secretion from Clonal INS-1 832/13 Cells

(2013) Isabel Göhring et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics and Fetal-Neonatal Nutrition: Between “Not Enough” and “Too Much”

(2013) Angelica Dessì et al.   MOLECULES

Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation

(2013) A. R. Macko et al.   Journal of Developmental Origins of Health and Disease

Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction

(2012) Anne-Karen von Beckerath et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep

(2012) Laura D. Brown et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Prolonged infusion of amino acids increases leucine oxidation in fetal sheep

(2012) Anne M. Maliszewski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheep

(2012) Monika M. Gadhia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supply

(2012) Jinny R. Lavezzi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Insulin Sensitivity and  -Cell Function in Adults Born Preterm and Their Children

(2012) S. Mathai et al.   DIABETES

Physiopathology of intrauterine growth retardation: from classic data to metabolomics

(2012) Angelica Dessì et al.   Journal of Maternal-Fetal & Neonatal Medicine

Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep

(2012) Dustin T. Yates et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabolomic analysis of pancreatic β-cell insulin release in response to glucose

(2012) Mei Huang et al.   Islets

Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb’s cycle flux independent of ATP synthesis

(2011) Gary W. Cline et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

(2011) Peter Spégel et al.   BIOCHEMICAL JOURNAL

Sildenafil citrate therapy for severe early-onset intrauterine growth restriction

(2011) P von Dadelszen et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat

(2011) S. E. Pinney et al.   DIABETOLOGIA

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

(2011) Andreas Wiederkehr et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Impact of Birth Weight and Early Infant Weight Gain on Insulin Resistance and Associated Cardiovascular Risk Factors in Adolescence

(2011) Signe Fabricius-Bjerre et al.   PLoS One

Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction

(2010) Rafael A. Leos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of Blood Vessels, Endothelial Cells, and Vascular Pericytes in Insulin Secretion and Peripheral Insulin Action

(2010) Oliver C. Richards et al.   ENDOCRINE REVIEWS

Consequences of a compromised intrauterine environment on islet function

(2010) Alice S Green et al.   JOURNAL OF ENDOCRINOLOGY

Cross-fostering and improved lactation ameliorates deficits in endocrine pancreatic morphology in growth-restricted adult male rat offspring

(2010) A. L. Siebel et al.   Journal of Developmental Origins of Health and Disease

Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation

(2009) Paul J. Rozance et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Advances in beta-cell imaging

(2009) Anna Moore   EUROPEAN JOURNAL OF RADIOLOGY

Metabolomics: a new tool for the neonatologist

(2009) Luigi Atzori et al.   Journal of Maternal-Fetal & Neonatal Medicine

Sildenafil Citrate Treatment Enhances Amino Acid Availability in the Conceptus and Fetal Growth in an Ovine Model of Intrauterine Growth Restriction

(2009) M. Carey Satterfield et al.   JOURNAL OF NUTRITION

Exendin-4 Normalizes Islet Vascularity in Intrauterine Growth Restricted Rats: Potential Role of VEGF

(2009) J Nina Ham et al.   PEDIATRIC RESEARCH

Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

(2009) A. H. Rosengren et al.   SCIENCE

The transplacental transport of essential amino acids in uncomplicated human pregnancies

(2008) Henry L. Galan et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus

(2008) Laura D. Brown et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Noninvasive assessment of pancreatic β-cell function in vivo with manganese-enhanced magnetic resonance imaging

(2008) Patrick F. Antkowiak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impaired β-Cell Function and Inadequate Compensatory Increases in β-Cell Mass after Intrauterine Growth Restriction in Sheep

(2008) Kathryn L. Gatford et al.   ENDOCRINOLOGY

Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep

(2008) A L David et al.   GENE THERAPY

Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets

(2008) Lara R. Nyman et al.   JOURNAL OF CLINICAL INVESTIGATION

Noninvasive in vivo imaging of pancreatic islet cell biology

(2008) Stephan Speier et al.   NATURE MEDICINE

Strategies for Feeding the Preterm Infant

(2008) William W. Hay et al.   Neonatology

Glucose Replacement to Euglycemia Causes Hypoxia, Acidosis, and Decreased Insulin Secretion in Fetal Sheep With Intrauterine Growth Restriction

(2008) Paul J Rozance et al.   PEDIATRIC RESEARCH

Diagnosis of IUGR: Traditional Biometry

(2008) Elizabeth Platz et al.   SEMINARS IN PERINATOLOGY

Non-Placental Causes of Intrauterine Growth Restriction

(2008) Nancy Hendrix et al.   SEMINARS IN PERINATOLOGY