Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice

(2016) Elena A. Komarova et al.   Aging-US

Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

(2016) Carolina B. Livi et al.   Aging-US

Effect of Different Immunosuppressive Drugs on Immune Cells from Young and Old Healthy Persons

(2014) Kathrin Welzl et al.   GERONTOLOGY

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

(2013) Dudley W. Lamming et al.   AGING CELL

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice

(2013) Yimin Fang et al.   Cell Metabolism

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

ScientiFig: a tool to build publication-ready scientific figures

(2013) Benoit Aigouy et al.   NATURE METHODS

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Cardiac mTOR protects the heart against ischemia-reperfusion injury

(2012) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Rapamycin slows aging in mice

(2012) Adam Spong et al.   CELL CYCLE

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8+ T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques

(2011) A. P. Turner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

(2010) Subhash D. Katewa et al.   EXPERIMENTAL GERONTOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

A midlife longevity drug?

(2009) Matt Kaeberlein et al.   NATURE

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

(2009) S. Someya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA