Why Is Aging Conserved and What Can We Do about It?

DNA methylation age of blood predicts all-cause mortality in later life

(2015) Riccardo E Marioni et al.   GENOME BIOLOGY

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

(2014) C. A. Bannister et al.   DIABETES OBESITY & METABOLISM

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Telomere length behaves as biomarker of somatic redundancy rather than biological age

(2013) Jelle J. Boonekamp et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Aging is not programmed

(2013) Mikhail V Blagosklonny   CELL CYCLE

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

The key role of growth hormone–insulin–IGF-1 signaling in aging and cancer

(2013) Vladimir N. Anisimov et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

(2013) Dana P. Goldman et al.   HEALTH AFFAIRS

Life-Span Extension From Hypoxia in Caenorhabditis elegans Requires Both HIF-1 and DAF-16 and Is Antagonized by SKN-1

(2013) Scott F. Leiser et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Preserving Youth: Does Rapamycin Deliver?

(2013) S. C. Johnson et al.   Science Translational Medicine

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Gene expression analysis of mTOR pathway: association with human longevity

(2012) Willemijn M. Passtoors et al.   AGING CELL

The caloric restriction paradigm: Implications for healthy human aging

(2012) Rozalyn M. Anderson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

(2012) David Gems et al.   Annual Review of Physiology

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Systems Biology in Aging: Linking the Old and the Young

(2012) Lei Hou et al.   CURRENT GENOMICS

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

(2011) Scott F. Leiser et al.   AGING CELL

Sensory Perception and Aging in Model Systems: From the Outside In

(2011) Nancy J. Linford et al.   Annual Review of Cell and Developmental Biology

Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction

(2011) Jin-Ying Lu et al.   CELL

On the Programmed/Non-Programmed Nature of Ageing within the Life History

(2011) Thomas B.L. Kirkwood et al.   CURRENT BIOLOGY

Calorie restriction and prevention of age-associated chronic disease

(2011) Daniela Omodei et al.   FEBS LETTERS

Mortality in North American Dogs from 1984 to 2004: An Investigation into Age-, Size-, and Breed-Related Causes of Death

(2011) J.M. Fleming et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Survival costs of reproduction in Drosophila

(2010) Thomas Flatt   EXPERIMENTAL GERONTOLOGY

Lifespan and oxidative stress show a non-linear response to atmospheric oxygen in Drosophila

(2010) B. Rascon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Is Telomere Length a Biomarker of Aging? A Review

(2010) K. A. Mather et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Update on Slow Aging and Negligible Senescence – A Mini-Review

(2009) Caleb E. Finch   GERONTOLOGY

Masters of Longevity: Lessons from Long-Lived Bivalves – A Mini-Review

(2009) Eva E.R. Philipp et al.   GERONTOLOGY

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

(2008) Erica D Smith et al.   BMC DEVELOPMENTAL BIOLOGY

Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species

(2008) Rochelle Buffenstein   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA