Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents

The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes

(2012) Dumitru Constantin-Teodosiu et al.   DIABETES

Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins

(2012) P. Sirvent et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effect of a high dose of simvastatin on muscle mitochondrial metabolism and calcium signaling in healthy volunteers

(2012) F. Galtier et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

(2011) Peter J. Mullen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

(2011) Hyo-Bum Kwak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

(2011) Lokendra Kumar Sharma et al.   HUMAN MOLECULAR GENETICS

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Atorvastatin treatment reduces exercise capacities in rats: involvement of mitochondrial impairments and oxidative stress

(2011) Jamal Bouitbir et al.   JOURNAL OF APPLIED PHYSIOLOGY

Novel events in the molecular regulation of muscle mass in critically ill patients

(2011) Despina Constantin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells

(2010) Leonie E. C. van Meijl et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pivotal Role of the C-terminal DW-motif in Mediating Inhibition of Pyruvate Dehydrogenase Kinase 2 by Dichloroacetate

(2009) Jun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrophobic statins induce autophagy in cultured human rhabdomyosarcoma cells

(2008) Makoto Araki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle

(2008) Hannah Crossland et al.   JOURNAL OF PHYSIOLOGY-LONDON

PPARδ agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction

(2008) Dumitru Constantin-Teodosiu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy

(2008) Joanne E. Mallinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rosuvastatin: Characterization of Induced Myopathy in the Rat

(2008) F. Russell Westwood et al.   TOXICOLOGIC PATHOLOGY