Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content

HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome

(2013) Nerea Hermida et al.   CARDIOVASCULAR RESEARCH

Ubiquinol rescues simvastatin-suppression of mitochondrial content, function and metabolism: Implications for statin-induced rhabdomyolysis

(2013) Roger A. Vaughan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Decreased skeletal muscle mitochondrial DNA in patients with statin-induced myopathy

(2013) Henry A.J. Stringer et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo

(2013) Ioanna Gouni-Berthold et al.   PLoS One

Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate

(2013) Dumitru Constantin-Teodosiu   Diabetes & Metabolism Journal

AMP-activated protein kinase stimulates myostatin expression in C2C12 cells

(2012) Arun K. Das et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents

(2012) Joanne E. Mallinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Atorvastatin and pitavastatin enhance lipoprotein lipase production in L6 skeletal muscle cells through activation of adenosine monophosphate-activated protein kinase

(2012) Masahiro Ohira et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity

(2012) Hayley M. O’Neill et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

(2011) Peter J. Mullen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

(2011) Craig A. Goodman et al.   CELLULAR SIGNALLING

Statin myopathy: A common dilemma not reflected in clinical trials

(2011) G. FERNANDEZ et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

(2011) Jamal Bouitbir et al.   EUROPEAN HEART JOURNAL

Retraction: Myostatin Induces Degradation of Sarcomeric Proteins through a Smad3 Signaling Mechanism During Skeletal Muscle Wasting

(2011) Sudarsanareddy Lokireddy et al.   MOLECULAR ENDOCRINOLOGY

Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

(2010) Jeffrey J. Brault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atorvastatin upregulates nitric oxide synthases with Rho-kinase inhibition and Akt activation in the kidney of spontaneously hypertensive rats

(2010) Daisuke Ito et al.   JOURNAL OF HYPERTENSION

Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis

(2010) Naoki Suzuki et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Statin-associated myopathy and its exacerbation with exercise

(2010) Benjamin M. Meador et al.   MUSCLE & NERVE

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Managing Statin Myopathy

(2009) Carmelo V. Venero et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect

(2009) Peirang Cao et al.   FASEB JOURNAL

Skeletal Muscle AMP-activated Protein Kinase Is Essential for the Metabolic Response to Exercisein Vivo

(2009) Robert S. Lee-Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression

(2008) Takaaki Fujii et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AMP-Activated Protein Kinase Promotes the Differentiation of Endothelial Progenitor Cells

(2008) Xiaoxia Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Statins: established indications and controversial subgroups

(2008) J W. Jukema et al.   HEART

Statin Suppresses Apoptosis in Osteoblastic Cells: Role of Transforming Growth Factor-β-Smad3 Pathway

(2008) H. Kaji et al.   HORMONE AND METABOLIC RESEARCH

Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statinin Vivo

(2008) Hyoung Chul Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simvastatin Inhibits Central Sympathetic Outflow in Heart Failure by a Nitric-Oxide Synthase Mechanism

(2008) L. Gao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy

(2008) Joanne E. Mallinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy

(2008) Rajkumar s/o Dorajoo et al.   LIFE SCIENCES

Molecular basis for statin-induced muscle toxicity: implications and possibilities

(2008) Catherine Buettner et al.   PHARMACOGENOMICS

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS

Essential Role of TGF-β/Smad Pathway on Statin Dependent Vascular Smooth Muscle Cell Regulation

(2008) Juan Rodríguez-Vita et al.   PLoS One