Article
Cell Biology
Mikael Flockhart, Lina C. Nilsson, Senna Tais, Bjorn Ekblom, William Apro, Filip J. Larsen
Summary: Exercise training positively affects metabolic health, but excess exercise may lead to reduced mitochondrial function and impaired glucose tolerance. Studies have shown that world-class endurance athletes have issues with glucose control compared to matched control groups.
Review
Biochemistry & Molecular Biology
Axel Roemer, Thomas Linn, Sebastian F. Petry
Summary: Lipotoxicity is a major contributor to the development of type 2 diabetes by promoting mitochondrial dysfunction; it can lead to ATP deficiency, decreased beta-cell viability, but physiologically fatty acids are necessary for beta-cell function under proper conditions; cellular senescence is associated with lipotoxicity, and plant-based nutrients such as polyphenols may have protective effects against lipotoxicity and cellular senescence.
Article
Endocrinology & Metabolism
Sofiya Gancheva, Sabine Kahl, Dominik Pesta, Lucia Mastrototaro, Bedair Dewidar, Klaus Strassburger, Ehsan Sabah, Irene Esposito, Jurgen Weiss, Theresia Sarabhai, Martin Wolkersdorfer, Thomas Fleming, Peter Nawroth, Marcel Zimmermann, Andreas S. Reichert, Matthias Schlensak, Michael Roden
Summary: Individuals with type 2 diabetes have a higher risk of progressing from nonalcoholic fatty liver to steatohepatitis, fibrosis, and cirrhosis. The hepatic mitochondrial function in NASH patients with and without type 2 diabetes differs, impacting disease progression.
Article
Endocrinology & Metabolism
Sofiya Gancheva, Sabine Kahl, Dominik Pesta, Lucia Mastrototaro, Bedair Dewidar, Klaus Strassburger, Ehsan Sabah, Irene Esposito, Juergen Weiss, Theresia Sarabhai, Martin Wolkersdorfer, Thomas Fleming, Peter Nawroth, Marcel Zimmermann, Andreas S. Reichert, Matthias Schlensak, Michael Roden
Summary: Loss of hepatic mitochondrial adaptation characterizes NASH and type 2 diabetes or hepatic fibrosis and may thereby favor accelerated disease progression.
Article
Multidisciplinary Sciences
Julie S. Pedersen, Marte O. Rygg, Karoline Chrois, Elahu G. Sustarsic, Zach Gerhart-Hines, Nicolai J. Wever Albrechtsen, Reza R. Serizawa, Viggo B. Kristiansen, Astrid L. Basse, Astrid E. B. Boilesen, Beth H. Olsen, Torben Hansen, Lise Lotte Gluud, Sten Madsbad, Steen Larsen, Flemming Bendtsen, Flemming Dela
Summary: Impaired mitochondrial function in liver tissue may contribute to the pathogenesis and disease progression of nonalcoholic fatty liver disease (NAFLD). Patients with obesity have lower mitochondrial capacity in adipose tissues but higher capacity in the liver, without overall associations to NAFLD severity, and bariatric surgery increases hepatic mitochondrial respiration and mitochondrial biogenesis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Isy F. de Sousa, Vincenzo Migliaccio, Marilena Lepretti, Gaetana Paolella, Ilaria Di Gregorio, Ivana Caputo, Eliane Beraldi Ribeiro, Lilla Lionetti
Summary: This study evaluated the dose- and time-dependent effects of oleate and palmitate on mitochondrial fusion/fission proteins, finding that oleate had minimal impact on protein content and maintained cell viability, while palmitate reduced protein content and cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yuan Yao, Suya Feng, Xuejiao Li, Taohua Liu, Shengying Ye, Long Ma, Shuli Man
Summary: Litchi chinensis seed is rich in procyanidins, which have been shown to inhibit the proliferation and metastasis of colon cancer cells. This effect is mediated through modulation of gut microbiota, immune response, and regulation of metabolites such as acetic acid, propionic acid and butyric acid.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Katarzyna Lipke, Adriana Kubis-Kubiak, Agnieszka Piwowar
Summary: Free fatty acids (FFAs) play vital roles in the organism but disturbances in fatty acid homeostasis can lead to lipotoxicity, contributing to the development of diseases such as insulin resistance and diabetes. Lipotoxic effects primarily affect organs such as the pancreas, liver, skeletal muscles, cardiac muscle, and kidneys.
Review
Endocrinology & Metabolism
Kalliopi Pafili, Michael Roden
Summary: Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic alterations with increased lipid accumulation, mainly influenced by global obesity and diabetes epidemics. Recent studies have suggested that certain conditions, such as severe insulin-resistant diabetes (SIRD) subgroup and an increasing number of gene variants, predispose individuals to a higher risk of NAFLD and its accelerated progression.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Qi Hui Sam, Hua Ling, Wen Shan Yew, Zhaohong Tan, Sharada Ravikumar, Matthew Wook Chang, Louis Yi Ann Chai
Summary: Short chain fatty acids (SCFA) and medium chain fatty acids (MCFA) have divergent immunomodulatory propensities, with SCFA down-attenuating pro-inflammatory response through the TLR4 pathway, while MCFA augmenting inflammation through TLR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Javier Modrego, Adriana Ortega-Hernandez, Josebe Goirigolzarri, Maria Alejandra Restrepo-Cordoba, Christine Bauerl, Erika Cortes-Macias, Silvia Sanchez-Gonzalez, Alberto Esteban-Fernandez, Julian Perez-Villacastin, Maria Carmen Collado, Dulcenombre Gomez-Garre
Summary: A longitudinal study found that after 12 months of the initial heart failure episode, patients showed improved clinical parameters, reduced inflammation, and endothelial dysfunction, which were associated with the reversal of gut microbiota dysbiosis and increased production of the short-chain fatty acid butyrate. This suggests that restoring butyrate levels or promoting the growth of butyrate-producing bacteria could serve as a complementary treatment for heart failure patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Cesar Vasquez-Trincado, Mario Navarro-Marquez, Pablo E. Morales, Francisco Westermeier, Mario Chiong, Valentina Parra, Alejandra Espinosa, Sergio Lavandero
Summary: Cardiovascular diseases caused by high-fat foods are on the rise, leading to lipotoxicity at the cellular level. This study established a cardiomyocyte lipotoxicity model using the saturated fatty acid myristate and found that increased levels of the mitochondrial protein MUL1 were associated with mitochondrial fragmentation and cardiomyocyte hypertrophy. These findings reveal a novel connection between cardiomyocytes and lipotoxic stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Ying Guo, Teng Guan, Kashfia Shafiq, Qiang Yu, Xin Jiao, Donghui Na, Meiyu Li, Guohui Zhang, Jiming Kong
Summary: Aging is a complex process involving functional decline in multiple organelles. The role of mitochondrial quality control (MQC) in aging is still poorly understood, although mitochondrial dysfunction is suggested to be a determining factor. Evidence suggests that reactive oxygen species (ROS) stimulate changes in mitochondrial dynamics and contribute to the accumulation of oxidized by-products through mitochondrial proteases and mitochondrial unfolded protein response (UPRmt). MQC mechanisms such as mitochondrial-derived vesicles (MDVs) and mitophagy play crucial roles in maintaining mitochondrial homeostasis and preventing cellular senescence and aging. However, imbalanced MQC interventions may accelerate abnormal energy metabolism and senescence. Appropriate interventions on MQC may delay the aging process and extend lifespan.
AGEING RESEARCH REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Haiyan Chen, Wendan Pu, Xiankang Hu, Cheng Yang, Guanli Zhao, Houyuan Hu, Jianxiang Zhang
Summary: This article reports a mitochondrial-mimetic therapy for dilated cardiomyopathy (DCM) that efficiently targets the heart, cardiomyocytes, and myocardial mitochondria, effectively regulating mitochondrial homeostasis. By synthesizing a bioactive conjugate TPT and delivering it intravenously, TPTN can accumulate in the heart and primarily localize in the cardiomyocytes and myocardial mitochondria, alleviating DCM. By packaging TPTN into outer mitochondrial membrane-derived vesicles, a mitochondrial-mimetic therapy with enhanced targeting capability is created, providing notable therapeutic effects in DCM mice.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Zhi-Kang Yao, Yen-Hsuan Jean, Sung-Chun Lin, Yu-Cheng Lai, Nan-Fu Chen, Chung-Chih Tseng, Wu-Fu Chen, Zhi-Hong Wen, Hsiao-Mei Kuo
Summary: Manoalide induces oxidative stress, mitochondrial dysfunction, and apoptosis in osteosarcoma cells, showing potential as an innovative alternative treatment for human osteosarcoma.
Article
Public, Environmental & Occupational Health
Aya Ahmed Abousheishaa, Nor Hazila Mat Lazim, Song Ling Tang, Ahmad Hatim Sulaiman, Hasniza Zaman Huri, Ng Chong Guan
Summary: This study developed and evaluated a decision aid tool for Malaysian patients with MDD to support treatment decision-making during consultation. The tool increased patients' involvement in shared decision making and enhanced their preparedness for decision making without extending the consultation time.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Health Care Sciences & Services
Aya Ahmed Abousheishaa, Ahmad Hatim Sulaiman, Hasniza Zaman Huri, Siti Fatimah Binti Kamis, Hafizah Hamidi, Wei Chern Ang, Zainol Akbar bin Zainal, Noorasyikin Shamsuddin, Ng Chong Guan
Summary: This study explored the extent and barriers of psychiatric pharmaceutical care in Malaysian hospitals. The results showed that pharmacists were effective in ensuring the appropriateness of medication dosage, dosage form, and dosing schedule. However, they were less involved in developing pharmacotherapeutic regimens and monitoring plans with patients and healthcare professionals. The study also identified various barriers perceived by pharmacists, such as lack of time, shortage of pharmacy staff, and patients' inability to comprehend medical information.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Environmental Sciences
Izyan A. A. Wahab, Khang Wen Goh, Zainol Akbar Zainal, Najlaa Siham Mohamed Mohamed Yusof, Hasniza Zaman Huri, Sabrina Anne Jacob, Muhammad Najib Mohamad Mohamad Alwi, Rosnani Hashim, Shairyzah Ahmad Ahmad Hisham, Nurdiana Jamil
Summary: This study aims to identify the relationship between university students' sociodemographic, psychosocial, and academic backgrounds and depression symptoms, in order to develop primary and secondary preventive strategies for mental health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Khim Boon Tee, Luqman Ibrahim, Najihah Mohd Hashim, Mohd Zuwairi Saiman, Zaril Harza Zakaria, Hasniza Zaman Huri
Summary: This protocol aims to study the pharmacokinetics of metformin and Andrographis paniculata (AP) and to analyze the metabolomics profiling associated with human metabolic pathways. It is a single-center, open-label, crossover, randomized-controlled, single-dose oral administration pharmacokinetics and metabolomics trial. The study will collect blood and urine samples to analyze the pharmacokinetics parameters and identify the dysregulation of human metabolic pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Khim Boon Tee, Luqman Ibrahim, Najihah Mohd Hashim, Mohd Zuwairi Saiman, Zaril Harza Zakaria, Hasniza Zaman Huri
Summary: Pharmacometabolomics in early phase clinical trials can provide insights into the metabolic profiles of subjects responding to drug treatment. This study integrates personalized pharmacokinetics and pharmacometabolomics to predict the pharmacodynamic response of human metabolic pathways for type 2 diabetes. Metformin, a commonly used glucose-lowering agent, was used as the model drug. The study revealed dysregulated metabolic pathways associated with metformin's pharmacological effects of increasing insulin sensitivity and lipid metabolism. The integration of pharmacokinetic and pharmacometabolomic approaches could guide the development of targeted therapy and improve prediction of drug response in clinical trials.
Review
Nutrition & Dietetics
Mohammed M. Hassanein, Hasniza Zaman Huri, Kauser Baig, Abduelmula R. Abduelkarem
Summary: Hormonal fluctuations, excessive clothing covering, sunscreen use, changes in body fat composition, a vitamin D-deficient diet, and a sedentary lifestyle can all predispose postmenopausal women to vitamin D deficiency. An effective supplementation plan requires a thorough understanding of underlying factors to achieve the desired therapeutic concentrations. This study conducted a systematic review to identify predictors that affect vitamin D status in postmenopausal women.
Article
Chemistry, Analytical
Thiruventhan Karunakaran, Yong Sean Goh, Rameshkumar Santhanam, Vikneswaran Murugaiyah, Mohamad Hafizi Abu Bakar, Surash Ramanathan
Summary: This study demonstrates the usage of a green extraction method to obtain noncytotoxic Ketum botanical extracts containing Mitragynine and its congeners.
Review
Biochemistry & Molecular Biology
Sangeetha Perumalsamy, Hasniza Zaman Huri, Bashar Mudhaffar Abdullah, Othman Mazlan, Wan Azman Wan Ahmad, Shireene Ratna D. B. Vethakkan
Summary: Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR), which is associated with atherosclerotic coronary artery disease (CAD). Endothelial dysfunction (ED) at the earliest stages of IR plays a role in the progression of atherosclerosis. Genes and their single nucleotide polymorphisms (SNPs) such as CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2, are potential genetic markers of IR and atherosclerosis.
Article
Integrative & Complementary Medicine
Aprilita Rina Yanti Eff, Hasniza Zaman Huri, Maksum Radji, Abdul Munim, F. D. Suyatna, Yonatan Eden
Summary: The fruit of Mahkota Dewa, also known as Phaleria macrocarpa, has been found to have various health benefits, such as lowering blood pressure, reducing plasma glucose levels, possessing antioxidant effects, and aiding in the recovery of liver and kidney damage in rats. This study isolated and identified three compounds from the fruit that have ACE inhibitory activity, with mangiferin showing the strongest ACE inhibitory activity through competitive inhibition kinetics.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Obstetrics & Gynecology
Mohammed M. Hassanein, Hasniza Zaman Huri, Kauser Baig, Abduelmula R. Abduelkarem, Marwan Al-Momani
Summary: This study developed and validated an electronic PROM specific for GSM patients, named GSM-SVTAQ. It accurately assessed the burden of GSM symptoms, their impact on health-related and sexual quality of life, and the acceptability of vaginal treatments. The PROM demonstrated excellent validity and strong internal consistency.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Correction
Public, Environmental & Occupational Health
Aya Ahmed Abousheishaa, Nor Hazila Mat Lazim, Song Ling Tang, Ahmad Hatim Sulaiman, Hasniza Zaman Huri, Ng Chong Guan
PATIENT EDUCATION AND COUNSELING
(2023)
Review
Nutrition & Dietetics
Mohammed M. Hassanein, Hasniza Zaman Huri, Abduelmula R. Abduelkarem, Kauser Baig
Summary: In recent years, there has been increasing evidence suggesting the potential role of vitamin D in women's health, particularly in postmenopausal women. This evidence includes the connection between vitamin D and various genitourinary disorders and symptoms. Clinical studies have found that vitamin D supplementation can improve vulvovaginal symptoms associated with the genitourinary syndrome of menopause (GSM), such as vaginal pH, dryness, sexual functioning, libido, and urinary tract infections. The effects of vitamin D are mediated through vitamin D receptors (VDRs) and its role in supporting immune function and modulating defense mechanisms. Further research is needed to fully understand these effects. This article aims to review the existing evidence on vitamin D's impact on the vaginal, sexual, and urological health of postmenopausal women. As research in this area continues, vitamin D has the potential to support urogenital and sexual health during the menopausal transition and postmenopausal periods.
Review
Biochemistry & Molecular Biology
Nava Yugavathy, Bashar Mudhaffar Abdullah, Soo Kun Lim, Abdul Halim Bin Abdul Gafor, Muh Geot Wong, Sunita Bavanandan, Hin Seng Wong, Hasniza Zaman Huri
Summary: This review discusses the treatment options for erythropoietin deficiency anaemia in chronic kidney disease patients, highlighting the potential risks associated with traditional treatments and introducing newer approaches such as slow-release and low-dosage intravenous iron, oral iron supplementation, erythropoietin-iron combination therapy, and hypoxia-inducible factor prolyl hydroxylase inhibitors. It emphasizes the need for precision medicine targeting the genetic components of anaemia and discusses the role of pharmacogenetic testing in optimizing treatment outcomes.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
N. K. Loganadan, H. Zaman Huri, S. R. Vethakkan, Z. Hussein
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Ahmed Hafedh Mohammed Mohammed, Khairul Anuar Shariff, Mohamad Hafizi Abu Bakar, Hasmaliza Mohamad
Summary: This review focuses on recent methods of fabricating porous beta-tricalcium phosphate (8-TCP) scaffolds for clinical applications. The selection of methods for fabricating porous 8-TCP scaffolds is influenced by cost, pore architecture, and microstructures. Highly porous 8-TCP scaffolds with appropriate pore size, porosity, and cost have been fabricated using methods such as gel casting and foam replication. However, some methods, such as gelatin-freeze casting and extrusion technique, have an impact on the mechanical properties of porous 8-TCP scaffolds with non-uniform pores. Additive manufacturing methods like 3-D printing have the potential to achieve highly porous 8-TCP scaffolds with appropriate pore size, porosity, and mechanical properties.
MATERIALS TODAY-PROCEEDINGS
(2022)