Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

Narrative Review: Statin-Related Myopathy

(2013) Tisha R. Joy   ANNALS OF INTERNAL MEDICINE

Simvastatin Effects on Skeletal Muscle

(2013) Steen Larsen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin

(2013) Ali S Alfazari et al.   BMC Pharmacology & Toxicology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of Hepatocellular Toxicity Associated with Dronedarone—A Comparison to Amiodarone

(2012) Andrea Felser et al.   TOXICOLOGICAL SCIENCES

Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins

(2012) P. Sirvent et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Simvastatin represses protein synthesis in the muscle-derived C2C12 cell line with a concomitant reduction in eukaryotic initiation factor 2B expression

(2011) Alexander P. Tuckow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

(2011) Peter J. Mullen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

(2011) Jamal Bouitbir et al.   EUROPEAN HEART JOURNAL

Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

(2011) Hyo-Bum Kwak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Rab1 GTPase and Endoplasmic Reticulum-to-Golgi Trafficking Underlies Statin's Toxicity in Rat Skeletal Myofibers

(2011) K. Sakamoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

The AMPK-FoxO3A axis as a target for cancer treatment

(2010) Fulvio Chiacchiera et al.   CELL CYCLE

Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy

(2009) Peter James Mullen et al.   BIOCHEMICAL PHARMACOLOGY

Modulation of impact of high fat diet in pathological and physiological left ventricular cardiac hypertrophy by fluvastatin

(2009) Randhir Singh et al.   BIOMEDICINE & PHARMACOTHERAPY

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms

(2009) Giulia Mearini et al.   CARDIOVASCULAR RESEARCH

Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect

(2009) Peirang Cao et al.   FASEB JOURNAL

Cardiac Hypertrophy During Hypercholesterolemia and Its Amelioration With Rosuvastatin and Amlodipine

(2009) Bum-Yong Kang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL