Effective asymmetric vinylogous Mannich reaction of isatin imines with α,α-dicyanoolefins in the presence of a simple chiral amide phosphonium bifunctional phase transfer catalyst

ChiralN,N′-Dioxide-Zinc(II) Complex-Catalyzed Asymmetric Aza-Friedel-Crafts Reaction of Isatin-Derived Ketimines with Indoles

(2016) Xiying Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

(2016) Fares Ibrahim Amr et al.   ADVANCED SYNTHESIS & CATALYSIS

Engaging Allene-Derived Zwitterions in an Unprecedented Mode of Asymmetric [3+2]-Annulation Reaction

(2016) Muthukumar G. Sankar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

(2016) Xiaoyu Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric synthesis of 3,3′-pyrrolidinyl-dispirooxindoles via a one-pot organocatalytic Mannich/deprotection/aza-Michael sequence

(2016) Kun Zhao et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

(2016) Carlos Vila et al.   Chemistry-An Asian Journal

Highly Enantioselective Conjugate Addition of Glycine Imines to Activated Alkenes Catalyzed by Amino-Acid-Derived Chiral Phosphonium Salts

(2016) Shan Wen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

α,α-Dicyanoolefins: versatile substrates in organocatalytic asymmetric transformations

(2016) Jasneet Kaur et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalyzed Asymmetric 1,6-Conjugate Addition of para-Quinone Methides with Dicyanoolefins

(2016) Xuanyi Li et al.   ORGANIC LETTERS

Asymmetric [3+2] annulations of 1,4-di-thiane-2,5-diol and oxindole ketimines

(2016) Bo-Xu Feng et al.   TETRAHEDRON LETTERS

Organocatalytic Enantioselective Friedel–Crafts Aminoalkylation of Indoles in the Carbocyclic Ring

(2016) Marc Montesinos-Magraner et al.   ACS Catalysis

An organocatalytic enantioselective vinylogous Mannich reaction of α,α-dicyanoolefins with isatin N-Boc ketimines

(2016) Yi Zhu et al.   Organic Chemistry Frontiers

Brønsted Acid-Catalyzed Enantioselective Synthesis of Isatin- DerivedN,S-Acetals

(2015) Christian Beceño et al.   ADVANCED SYNTHESIS & CATALYSIS

Stereoselective Organocatalytic Synthesis of Oxindoles with Adjacent Tetrasubstituted Stereocenters

(2015) Oliver D. Engl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

(2015) Marc Montesinos-Magraner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Enantioselective Aza-Diels-Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609

(2015) Haifeng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dipeptide-Derived Multifunctional Quaternary Phosphonium Salt Catalyzed Asymmetric Cyclizations via a Tandem Michael Addition/SN2 Sequence

(2015) Dongdong Cao et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Organocatalytic Mannich/Denitration Reaction for the Asymmetric Synthesis of 3-Ethylacetate-Substitued 3-Amino-2-Oxindoles: Formal Synthesis of AG-041R

(2015) Kun Zhao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modular Catalytic Synthesis of 3-Amino-3-aryl-2-oxindoles: Rh Catalysis with Isatin-DerivedN-Boc-Protected Ketimines

(2015) Carolina S. Marques et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chiral Bifunctional Guanidine-Catalyzed Enantioselective Aza-Henry Reaction of Isatin-Derived Ketimines

(2015) Bing Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Vicinal Tetrasubstituted Stereocenters with a C–F Bond through a Catalytic Enantioselective Detrifluoroacetylative Mannich Reaction

(2015) Xihong Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Linear α-Substituted Monothiomalonates with Isatin N-Boc Ketimines

(2015) Teng Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Regiodivergent Enantioselective γ-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α-Amino Acids and N,O-Acetal Derivatives

(2015) Tianli Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Maleimide as an efficient nucleophilic partner in the aza-Morita–Baylis–Hillman reaction: synthesis of chiral 3-substituted-3-aminooxindoles

(2015) Akshay Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A highly efficient Mukaiyama–Mannich reaction of N-Boc isatin ketimines and other active cyclic ketimines using difluoroenol silyl ethers catalyzed by Ph3PAuOTf

(2015) Jin-Sheng Yu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An enantioselective organocatalyzed aza-Morita–Baylis–Hillman reaction of isatin-derived ketimines with acrolein

(2015) Yasushi Yoshida et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines

(2015) Takayoshi Arai et al.   ORGANIC LETTERS

An Organocatalytic Asymmetric Friedel–Crafts Addition/Fluorination Sequence: Construction of Oxindole–Pyrazolone Conjugates Bearing Vicinal Tetrasubstituted Stereocenters

(2015) Xiaoze Bao et al.   ORGANIC LETTERS

Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatin-Derived Ketimines

(2015) Qun He et al.   ORGANIC LETTERS

Enantioselective Direct Mannich Reactions of Cyclic β-Ketoesters Catalyzed by Chiral Phosphine via a Novel Dual-Reagent Catalysis

(2015) Yan-Peng Lou et al.   ORGANIC LETTERS

Asymmetric addition of 3-substituted benzofuran-2-ones to isatin N-Boc ketimines catalyzed by chiral biscinchona alkaloid catalyst

(2015) Yi Zhu et al.   TETRAHEDRON

Asymmetric synthesis of chiral 3,3-disubstituted oxindoles using isatin as starting material

(2015) Ghodsi Mohammadi Ziarani et al.   TETRAHEDRON-ASYMMETRY

Chiral phosphine-catalyzed tunable cycloaddition reactions of allenoates with benzofuranone-derived olefins for a highly regio-, diastereo- and enantioselective synthesis of spiro-benzofuranones

(2015) De Wang et al.   Chemical Science

Enantioselective Synthesis of Polycyclic Indole Derivatives Based on aza-Morita–Baylis–Hillman Reaction

(2015) Yuning Gao et al.   ACS Catalysis

The origin for highly enantioselective induction of 1-naphthol to isatin-derived N-Boc ketimines catalyzed by quinine thiourea catalyst: an experimental and computational study

(2015) Prathibha kumari et al.   RSC Advances

Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation

(2015) Jasneet Kaur et al.   RSC Advances

Asymmetric Dual-Reagent Catalysis: Mannich-type Reactions Catalyzed by Ion Pair

(2014) Hong-Yu Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines

(2014) Jiannan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly enantioselective aza-Henry reaction with isatin N-Boc ketimines

(2014) Melireth Holmquist et al.   CHEMICAL COMMUNICATIONS

A Base-Free Neutral Phase-Transfer Reaction System

(2014) Seiji Shirakawa et al.   Chemistry-An Asian Journal

Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines

(2014) Tian-Ze Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Synthesis of 3,4-Dihydropyrans through a Phosphine-Catalyzed [4+2] Annulation of Allenones and β,γ-Unsaturated α-Keto Esters

(2014) Weijun Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective aza-Morita–Baylis–Hillman reaction between acrylates and N-Boc isatin ketimines: asymmetric construction of chiral 3-substituted-3-aminooxindoles

(2014) Xuan Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly enantioselective synthesis of bisoxindoles with two vicinal quaternary stereocenters via Lewis base mediated addition of oxindoles to isatin-derived ketimines

(2014) Zhongkai Tang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Direct Vinylogous Michael Addition to 2-Enoylpyridine N-Oxides Catalyzed by Bifunctional Thio-Urea

(2014) Subhrajit Rout et al.   ORGANIC LETTERS

Bis(imidazolidine)pyridine-NiCl2 Catalyst for Nitro-Mannich Reaction of Isatin-Derived N-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles

(2014) Takayoshi Arai et al.   ORGANIC LETTERS

Cinchona-derived thiourea catalyzed hydrophosphonylation of ketimines—an enantioselective synthesis of α-amino phosphonates

(2014) Akshay Kumar et al.   TETRAHEDRON

Organocatalytic direct asymmetric vinylogous Mannich reaction of γ-butenolides with isatin-derived ketimines

(2014) Yunlong Guo et al.   RSC Advances

Organocatalytic enantioselective aza-Henry reaction of ketimines derived from isatins: access to optically active 3-amino-2-oxindoles

(2014) Akshay Kumar et al.   RSC Advances

An Organocatalytic Addition of Nitromethane to Activated Ketimines

(2014) Yu-Hui Wang et al.   Asian Journal of Organic Chemistry

Amino Acid-Derived Phosphonium Salts-Catalyzed Michael Addition of 3-Substituted Oxindoles

(2013) Xiaoyu Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Thiourea-phosphonium salts from amino acids: cooperative phase-transfer catalysts in the enantioselective aza-Henry reaction

(2013) Dongdong Cao et al.   CHEMICAL COMMUNICATIONS

Base-Catalyzed Tandem Michael/Dehydro-Diels-Alder Reaction of α,α-Dicyanoolefins with Electron-Deficient 1,3-Conjugated Enynes: A Facile Entry to Angularly Fused Polycycles

(2013) Mingrui Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Squaramide-Catalysed Domino Mannich-Cyclization Reaction of Isatin Imines

(2013) Xi-Bo Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric catalytic aza-Morita–Baylis–Hillman reaction for the synthesis of 3-substituted-3-aminooxindoles with chiral quaternary carbon centers

(2013) Fang-Le Hu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

First example of quinine-squaramide catalyzed enantioselective addition of diphenyl phosphite to ketimines derived from isatins

(2013) Jimil George et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design of Chiral Bifunctional Quaternary Phosphonium Bromide Catalysts Possessing an Amide Moiety

(2013) Seiji Shirakawa et al.   ORGANIC LETTERS

Phase-Transfer-Catalyzed Asymmetric Conjugate Cyanation of Alkylidenemalonates with KCN in the Presence of a Brønsted Acid Additive

(2013) Yan Liu et al.   ORGANIC LETTERS

Catalytic enantioselective addition of alcohols to isatin-derived N-Boc ketimines

(2013) Tian-Ze Li et al.   TETRAHEDRON

Organocatalytic asymmetric synthesis of 3-amino-2-oxindole derivatives bearing a tetra-substituted stereocenter

(2013) Pankaj Chauhan et al.   TETRAHEDRON-ASYMMETRY

Enantioselective Addition of Thiols to Imines Catalyzed by Thiourea–Quaternary Ammonium Salts

(2013) Hong-Yu Wang et al.   ACS Catalysis

Organocatalytic Asymmetric Vinylogous Michael Addition of Dicyanoolefins to Imine Intermediates Generatedin situfrom Arenesulfonylalkylindoles

(2012) Xing-Li Zhu et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Phosphine Catalyzed Asymmetric Michael Addition of Oxindoles

(2012) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic and Enantioselective Mannich Reaction of Dicyanoolefins with α-Amido Sulfones

(2012) Jun Lu et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

(2012) Jingchao Feng et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

(2012) Yun-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Enantioselective Synthesis of AG-041R by using N-Heteroarenesulfonyl Cinchona Alkaloid Amides as Organocatalysts

(2012) Noriyuki Hara et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective and Solvent-Controlled Diastereoselective Mannich Reaction of Isatin Imines with Hydroxyacetone: Synthesis of 3-Substituted 3-Aminooxindoles

(2012) Qi-Xiang Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams

(2012) Hui Lv et al.   ORGANIC LETTERS

Synthesis of N-Alkoxycarbonyl Ketimines Derived from Isatins and Their Application in Enantioselective Synthesis of 3-Aminooxindoles

(2012) Wenjin Yan et al.   ORGANIC LETTERS

An Easy Entry to Optically Active Spiroindolinones: Chiral Brønsted Acid-Catalysed Pictet-Spengler Reactions of Isatins

(2011) Sara Duce et al.   ADVANCED SYNTHESIS & CATALYSIS

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties

(2011) Thorsten Oost et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-Derived Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers

(2011) Xiaoyu Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Pictet–Spengler reactions of isatins for the synthesis of spiroindolones

(2011) Joseph J. Badillo et al.   TETRAHEDRON LETTERS

Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

(2011) Ke Shen et al.   Chemical Science

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric [3+2] Cycloadditions of Allenoates and Dual Activated Olefins Catalyzed by Simple Bifunctional N-Acyl Aminophosphines

(2010) Hua Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly practical amino acid and alkaloid synthesis using designer chiral phase transfer catalysts as high-performance organocatalysts

(2010) Keiji Maruoka   CHEMICAL RECORD

A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction

(2010) Yun-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic and Electrophilic Approach to Oxindoles with C3-Quaternary Stereocenters

(2010) Jing Peng et al.   ORGANIC LETTERS

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Merging chiral organocatalysts: enantio- and diastereoselective direct vinylogous Mannich reaction of alkylimines

(2009) Xiao-Feng Xiong et al.   CHEMICAL COMMUNICATIONS

α,α-Dicyanoalkenes: versatile vinylogous nucleophiles for organic synthesis

(2009) Hai-Lei Cui et al.   CHEMICAL COMMUNICATIONS

Cinchona-based phase-transfer catalysts for asymmetric synthesis

(2009) Sang-sup Jew et al.   CHEMICAL COMMUNICATIONS

Dual Organocatalysis: Asymmetric Allylic-Allylic Alkylation of α,α-Dicyanoalkenes and Morita-Baylis-Hillman Carbonates

(2009) Hai-Lei Cui et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic and Enantioselective Direct Vinylogous Michael Addition to Maleimides

(2008) Jun Lu et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Michael Addition of Dicyanoolefins to α,β-Unsaturated Aldehydes in Aqueous Medium

(2008) Jun Lu et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic asymmetric vinylogous addition to quinones – formation of optically active α-aryl ketones

(2008) José Alemán et al.   CHEMICAL COMMUNICATIONS

Enantioselective direct vinylogous Michael addition reaction catalyzed by organic molecules

(2008) Jun Lu et al.   TETRAHEDRON LETTERS