ChiralN,N′-Dioxide-Zinc(II) Complex-Catalyzed Asymmetric Aza-Friedel-Crafts Reaction of Isatin-Derived Ketimines with Indoles

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

(2016) Xiaoyu Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derived imines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3′-oxindole] framework

(2016) Yue-Ming Wang et al.   CHEMICAL COMMUNICATIONS

Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2016) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists

(2016) Fei Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective Synthesis of Indole-Annulated Medium-Sized Rings

(2016) Lin Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Enantioselective Friedel–Crafts Aminoalkylation of Indoles in the Carbocyclic Ring

(2016) Marc Montesinos-Magraner et al.   ACS Catalysis

Catalytic asymmetric α-amination of β-keto esters and β-keto amides with a chiral N,N′-dioxide–copper(i) complex

(2016) Xiao Xiao et al.   Organic Chemistry Frontiers

Brønsted Acid-Catalyzed Enantioselective Synthesis of Isatin- DerivedN,S-Acetals

(2015) Christian Beceño et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

(2015) Marc Montesinos-Magraner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Enantioselective Aza-Diels-Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609

(2015) Haifeng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reversal of enantioselective Friedel–Crafts C3-alkylation of pyrrole by slightly tuning the amide units of N,N′-dioxide ligands

(2015) Yulong Zhang et al.   CHEMICAL COMMUNICATIONS

Heterocyclic scaffolds as promising anticancer agents against tumours of the central nervous system: Exploring the scope of indole and carbazole derivatives

(2015) Chris Sherer et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A review on recent developments of indole-containing antiviral agents

(2015) Ming-Zhi Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chiral Bifunctional Guanidine-Catalyzed Enantioselective Aza-Henry Reaction of Isatin-Derived Ketimines

(2015) Bing Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Vicinal Tetrasubstituted Stereocenters with a C–F Bond through a Catalytic Enantioselective Detrifluoroacetylative Mannich Reaction

(2015) Xihong Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Enantioselective Peroxidation of Ketimines Derived from Isatins

(2015) Shuichi Nakamura et al.   ORGANIC LETTERS

An Organocatalytic Asymmetric Friedel–Crafts Addition/Fluorination Sequence: Construction of Oxindole–Pyrazolone Conjugates Bearing Vicinal Tetrasubstituted Stereocenters

(2015) Xiaoze Bao et al.   ORGANIC LETTERS

Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatin-Derived Ketimines

(2015) Qun He et al.   ORGANIC LETTERS

Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation

(2015) Jasneet Kaur et al.   RSC Advances

Asymmetric aza-Henry reaction to provide oxindoles with quaternary carbon stereocenter catalyzed by a metal-templated chiral Brønsted base

(2015) Ying Hu et al.   Organic Chemistry Frontiers

Catalytic Asymmetric [8+2] Cycloaddition for the Construction of Cycloheptatriene-Fused Pyrrolidin-3,3’-Oxindoles

(2015) Mingsheng Xie et al.   ACTA CHIMICA SINICA

Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines

(2014) Jiannan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly enantioselective aza-Henry reaction with isatin N-Boc ketimines

(2014) Melireth Holmquist et al.   CHEMICAL COMMUNICATIONS

Synthetic Approaches to 3-(2-Nitroalkyl) Indoles and Their Use to Access Tryptamines and Related Bioactive Compounds

(2014) Stefano Lancianesi et al.   CHEMICAL REVIEWS

(DHQ)2AQN-Catalyzed Asymmetric Substitution of Isatin-Derived Hydrazones with O-Boc-Protected Morita–Baylis–Hillman Adducts: A Strategy for Synthesizing Enantioenriched Azo Compounds Incorporating an Oxindole Scaffold

(2014) Hai-Bin Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines

(2014) Tian-Ze Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective aza-Morita–Baylis–Hillman reaction between acrylates and N-Boc isatin ketimines: asymmetric construction of chiral 3-substituted-3-aminooxindoles

(2014) Xuan Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic Enantioselective Addition of Thiols to Ketimines Derived from Isatins

(2014) Shuichi Nakamura et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Chemoselective Cross-Aza-Benzoin Reaction of Enals with Isatin-Derived Ketimines: Access to Chiral Quaternary Aminooxindoles

(2014) Jianfeng Xu et al.   ORGANIC LETTERS

Bis(imidazolidine)pyridine-NiCl2 Catalyst for Nitro-Mannich Reaction of Isatin-Derived N-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles

(2014) Takayoshi Arai et al.   ORGANIC LETTERS

Bifunctional N-Heterocyclic Carbene-Catalyzed Highly Enantioselective Synthesis of Spirocyclic Oxindolo-β-lactams

(2014) Han-Ming Zhang et al.   ORGANIC LETTERS

Cinchona-derived thiourea catalyzed hydrophosphonylation of ketimines—an enantioselective synthesis of α-amino phosphonates

(2014) Akshay Kumar et al.   TETRAHEDRON

Organocatalytic enantioselective aza-Henry reaction of ketimines derived from isatins: access to optically active 3-amino-2-oxindoles

(2014) Akshay Kumar et al.   RSC Advances

Chiral N,N′-dioxide ligands: synthesis, coordination chemistry and asymmetric catalysis

(2014) Xiaohua Liu et al.   Organic Chemistry Frontiers

Catalytic Asymmetric 1,3-Dipolar Cycloadditions of Alkynes with Isatin-Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline-3,2′-pyrrole] Derivatives

(2013) Feng Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Scandium(III)-Catalyzed Enantioselective α-Arylation of N-Unprotected 3-Substituted Oxindoles with Diaryliodonium Salts

(2013) Jing Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric catalytic aza-Morita–Baylis–Hillman reaction for the synthesis of 3-substituted-3-aminooxindoles with chiral quaternary carbon centers

(2013) Fang-Le Hu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

First example of quinine-squaramide catalyzed enantioselective addition of diphenyl phosphite to ketimines derived from isatins

(2013) Jimil George et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2′-oxindole] Derivatives

(2013) Xianjie Chen et al.   ORGANIC LETTERS

Organocatalytic asymmetric synthesis of 3-amino-2-oxindole derivatives bearing a tetra-substituted stereocenter

(2013) Pankaj Chauhan et al.   TETRAHEDRON-ASYMMETRY

ChiralN,N'-Dioxide-Ni(II) Complex Catalyzed Asymmetric Carbonyl-Ene Reaction of Ethyl Trifluoropyruvate

(2012) Ke Zheng et al.   ACTA CHIMICA SINICA

Catalytic Generation of Zinc Carbenes from Alkynes: Zinc-Catalyzed Cyclopropanation and SiH Bond Insertion Reactions

(2012) Rubén Vicente et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

(2012) Jingchao Feng et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

(2012) Yun-Lin Liu et al.   CHEMICAL COMMUNICATIONS

N-Heterocyclic Carbene-Catalyzed Homoenolate Additions with N-Aryl Ketimines as Electrophiles: Efficient Synthesis of Spirocyclic γ-Lactam Oxindoles

(2012) Bo Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of AG-041R by using N-Heteroarenesulfonyl Cinchona Alkaloid Amides as Organocatalysts

(2012) Noriyuki Hara et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams

(2012) Hui Lv et al.   ORGANIC LETTERS

Synthesis of N-Alkoxycarbonyl Ketimines Derived from Isatins and Their Application in Enantioselective Synthesis of 3-Aminooxindoles

(2012) Wenjin Yan et al.   ORGANIC LETTERS

ChiralN,N′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions

(2011) XiaoHua Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

(2011) Ke Shen et al.   Chemical Science

Optimization of the Central Core of Indolinone–Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists

(2011) Stefano Crosignani et al.   ACS Medicinal Chemistry Letters

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of theMycobacterium tuberculosisProtein Tyrosine Phosphatase B

(2010) Viktor V. Vintonyak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

(2010) Mohamed Ashraf Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Zinc-Catalyzed Reduction of Amides: Unprecedented Selectivity and Functional Group Tolerance

(2010) Shoubhik Das et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction

(2010) Yun-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Nonlinear Effects in Asymmetric Catalysis

(2009) Tummanapalli Satyanarayana et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Functionalization of Indoles in a New Dimension

(2009) Marco Bandini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Friedel−Crafts Alkylation of Pyrroles with Nitroalkenes Using a Dinuclear Zinc Catalyst

(2008) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY