Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

H-Bond-Directing Organocatalyst for Enantioselective [4 + 2] Cycloadditions via Dienamine Catalysis

(2016) Shoulei Wang et al.   ORGANIC LETTERS

Enantioselective Synthesis of Dihydrospiro[indoline-3,4′-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction

(2016) Nandarapu Kumarswamyreddy et al.   ORGANIC LETTERS

Aza-Henry Reaction of Isatin Ketimines with Methyl 4-Nitrobutyrate en Route to Spiro[piperidine-3,3′-oxindoles]

(2015) Melireth Holmquist et al.   ADVANCED SYNTHESIS & CATALYSIS

Bifunctional Amine-Squaramides: Powerful Hydrogen-Bonding Organocatalysts for Asymmetric Domino/Cascade Reactions

(2015) Pankaj Chauhan et al.   ADVANCED SYNTHESIS & CATALYSIS

Regio- and Enantioselective Synthesis of N-Substituted Pyrazoles by Rhodium-Catalyzed Asymmetric Addition to Allenes

(2015) Alexander M. Haydl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Quaternary Carbon Stereocenters: Addition of 3-Substituted Oxindoles to Vinyl Sulfone Catalyzed by Pentanidiums

(2015) Lili Zong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective Organocatalytic Synthesis of Oxindoles with Adjacent Tetrasubstituted Stereocenters

(2015) Oliver D. Engl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

(2015) Marc Montesinos-Magraner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

(2015) Daniel Hack et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Chiral Pyrazoles: A 1,3-Dipolar Cycloaddition/[1,5] Sigmatropic Rearrangement with Stereoretentive Migration of a Stereogenic Group

(2015) M. Carmen Pérez-Aguilar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quinoline-based antimalarial hybrid compounds

(2015) Stéphanie Vandekerckhove et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives

(2015) Pankaj Chauhan et al.   CHEMICAL COMMUNICATIONS

Combining silver- and organocatalysis: an enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles

(2015) Daniel Hack et al.   CHEMICAL COMMUNICATIONS

An Organocatalytic Mannich/Denitration Reaction for the Asymmetric Synthesis of 3-Ethylacetate-Substitued 3-Amino-2-Oxindoles: Formal Synthesis of AG-041R

(2015) Kun Zhao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole-Derived Molecular Architectures

(2015) Yongqiang Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Phase-Transfer-Catalyzed Asymmetric Synthesis of ChiralN-Substituted Pyr­azoles by Aza-Michael Reaction

(2015) Su-Jeong Lee et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective synthesis of chiral heterocycles containing both chroman and pyrazolone derivatives catalysed by a chiral squaramide

(2015) Jun-Hua Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An Organocatalytic Asymmetric Friedel–Crafts Addition/Fluorination Sequence: Construction of Oxindole–Pyrazolone Conjugates Bearing Vicinal Tetrasubstituted Stereocenters

(2015) Xiaoze Bao et al.   ORGANIC LETTERS

Enantioselective Synthesis of Functionalized Pyrazoles by NHC-Catalyzed Reaction of Pyrazolones with α,β-Unsaturated Aldehydes

(2015) Santhivardhana Reddy Yetra et al.   ORGANIC LETTERS

A Journey in the Catalytic Synthesis of 3-Substituted 3-Amino­oxindoles

(2015) Jian Zhou et al.   SYNLETT

Oxindole alkaloids from the fungus Penicillium commune DFFSCS026 isolated from deep-sea-derived sediments

(2015) Xinya Xu et al.   TETRAHEDRON

New oxindole alkaloids from Gelsemium elegans

(2015) Ming-Xue Sun et al.   TETRAHEDRON LETTERS

The origin for highly enantioselective induction of 1-naphthol to isatin-derived N-Boc ketimines catalyzed by quinine thiourea catalyst: an experimental and computational study

(2015) Prathibha kumari et al.   RSC Advances

Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation

(2015) Jasneet Kaur et al.   RSC Advances

Enantioselective Protonation by Aza-Michael Reaction between Pyrazoles and α-Substituted Vinyl Ketones

(2014) Jianlin Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Spiropyrazolones through Phosphine-Catalyzed [4+1] Annulation

(2014) Xiaoyu Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines

(2014) Jiannan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coumarin hybrids as novel therapeutic agents

(2014) Sonali Sandhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Highly enantioselective aza-Henry reaction with isatin N-Boc ketimines

(2014) Melireth Holmquist et al.   CHEMICAL COMMUNICATIONS

Design Strategies for Enhanced Hydrogen-Bond Donor Catalysts

(2014) Tyler J. Auvil et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Addition of Nitromethane to 2-Acylpyridine N-Oxides. Expanding the Generation of Quaternary Stereocenters with the Henry Reaction

(2014) Melireth Holmquist et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Chemoselective Cross-Aza-Benzoin Reaction of Enals with Isatin-Derived Ketimines: Access to Chiral Quaternary Aminooxindoles

(2014) Jianfeng Xu et al.   ORGANIC LETTERS

Bis(imidazolidine)pyridine-NiCl2 Catalyst for Nitro-Mannich Reaction of Isatin-Derived N-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles

(2014) Takayoshi Arai et al.   ORGANIC LETTERS

Bifunctional N-Heterocyclic Carbene-Catalyzed Highly Enantioselective Synthesis of Spirocyclic Oxindolo-β-lactams

(2014) Han-Ming Zhang et al.   ORGANIC LETTERS

Catalytic Enantioselective Allylation of Ketimines by Using Palladium Pincer Complexes with Chiral Bis(imidazoline)s

(2013) Shuichi Nakamura et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pyrazole containing natural products: Synthetic preview and biological significance

(2013) Vinod Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pd-Catalyzed Asymmetric Allylic Alkylation of Pyrazol-5-ones with Allylic Alcohols: The Role of the Chiral Phosphoric Acid in C–O Bond Cleavage and Stereocontrol

(2013) Zhong-Lin Tao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of highly substituted pyrazole derivatives with P–C bond: access to racemic and enantioselective forms by conjugate addition of diarylphosphane oxides to α,β-unsaturated pyrazolones

(2013) Zhi-Cong Geng et al.   TETRAHEDRON

Organocatalytic asymmetric synthesis of 3-amino-2-oxindole derivatives bearing a tetra-substituted stereocenter

(2013) Pankaj Chauhan et al.   TETRAHEDRON-ASYMMETRY

Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N′-Dioxide-Metal Complexes

(2012) Zhen Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

(2012) Jingchao Feng et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

(2012) Yun-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Synthesis of β-Pyrazole-Substituted Alcohols through an Asymmetric Ring-Opening Reaction of meso-Epoxides

(2012) Xiaolei Hu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of AG-041R by using N-Heteroarenesulfonyl Cinchona Alkaloid Amides as Organocatalysts

(2012) Noriyuki Hara et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective synthesis of novel pyrazole derivatives using tert-butansulfonamide as a chiral auxiliary

(2012) Chang Min Park et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic One-Pot Asymmetric Synthesis of 4H,5H-Pyrano[2,3-c]pyrazoles

(2012) Dieter Enders et al.   ORGANIC LETTERS

Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral Metal/N,N′-Dioxide Complexes: Metal-Directed Switch in Enantioselectivity

(2011) Zhen Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles

(2011) Santos Fustero et al.   CHEMICAL REVIEWS

Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis

(2011) José Alemán et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hybrid Molecules Incorporating Natural Products: Applications in Cancer Therapy, Neurodegenerative Disorders and Beyond

(2011) M. Decker   CURRENT MEDICINAL CHEMISTRY

Recent Advances in the Chemistry of Pyrazoles. Properties, Biological Activities, and Syntheses

(2011) Andreas Schmidt et al.   CURRENT ORGANIC CHEMISTRY

Enantioselective Synthesis of Tertiary Alcohols through a Zirconium-Catalyzed Friedel–Crafts Alkylation of Pyrroles with α-Ketoesters

(2011) Gonzalo Blay et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)3/N,N′-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives

(2011) Zhigang Yang et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Michael Addition of Pyrazolin-5-ones to Nitroolefins with Bifunctional Thiourea: Stereocontrolled Construction of Contiguous Quaternary and Tertiary Stereocenters

(2010) Yu-Hua Liao et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Development of Chiral Thiourea Catalysts and Its Application to Asymmetric Catalytic Reactions

(2010) Yoshiji Takemoto   CHEMICAL & PHARMACEUTICAL BULLETIN

Recent Progress in the Development of Synthetic Hybrids of Natural or Unnatural Bioactive Compounds for Medicinal Chemistry

(2010) Svetlana B. Tsogoeva   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Cinchona Alkaloids in Asymmetric Organocatalysis

(2010) Tommaso Marcelli et al.   SYNTHESIS-STUTTGART

(Thio)urea organocatalysis—What can be learnt from anion recognition?

(2009) Zhiguo Zhang et al.   CHEMICAL SOCIETY REVIEWS

Hybrid Drugs for Malaria

(2009) J. Walsh et al.   CURRENT PHARMACEUTICAL DESIGN

Enantioselective Synthesis of Janus Kinase Inhibitor INCB018424 via an Organocatalytic Aza-Michael Reaction

(2009) Qiyan Lin et al.   ORGANIC LETTERS

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Organocatalyzed enantioselective synthesis of 6-amino-5-cyanodihydropyrano[2,3-c]pyrazoles

(2009) Sanjib Gogoi et al.   TETRAHEDRON LETTERS

Asymmetric catalysis with bifunctional cinchona alkaloid-based urea and thiourea organocatalysts

(2008) Stephen J. Connon   CHEMICAL COMMUNICATIONS

Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models

(2008) Y. Fujimori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chiral Squaramide Derivatives are Excellent Hydrogen Bond Donor Catalysts

(2008) Jeremiah P. Malerich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-peptide arginine-vasopressin antagonists: the vaptans

(2008) Guy Decaux et al.   LANCET

Enantioselective Zirconium-Catalyzed Friedel−Crafts Alkylation of Pyrrole with Trifluoromethyl Ketones

(2008) Gonzalo Blay et al.   ORGANIC LETTERS