Phenotypic Differences in Virulence and Immune Response in Closely Related Clinical Isolates of Influenza A 2009 H1N1 Pandemic Viruses in Mice

Induction of Proinflammatory Cytokines in Primary Human Macrophages by Influenza A Virus (H5N1) Is Selectively Regulated by IFN Regulatory Factor 3 and p38 MAPK

(2014) K. P. Y. Hui et al.   JOURNAL OF IMMUNOLOGY

Critical Role of Natural Killer Cells in Lung Immunopathology During Influenza Infection in Mice

(2012) Mohamed F. Abdul-Careem et al.   JOURNAL OF INFECTIOUS DISEASES

Implication of Inflammatory Macrophages, Nuclear Receptors, and Interferon Regulatory Factors in Increased Virulence of Pandemic 2009 H1N1 Influenza A Virus after Host Adaptation

(2012) L. Josset et al.   JOURNAL OF VIROLOGY

IFITM3 restricts the morbidity and mortality associated with influenza

(2012) Aaron R. Everitt et al.   NATURE

Emerged HA and NA Mutants of the Pandemic Influenza H1N1 Viruses with Increasing Epidemiological Significance in Taipei and Kaohsiung, Taiwan, 2009–10

(2012) Chuan-Liang Kao et al.   PLoS One

Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia

(2011) Nelson Lee et al.   ANTIVIRAL THERAPY

Genomic analysis of pandemic (H1N1) 2009 reveals association of increasing disease severity with emergence of novel hemagglutinin mutations

(2011) Gennadi V. Glinsky   CELL CYCLE

Neutrophils sustain effective CD8+ T-cell responses in the respiratory tract following influenza infection

(2011) Michelle D Tate et al.   IMMUNOLOGY AND CELL BIOLOGY

Evidence of the circulation of pandemic influenza (H1N1) 2009 with D222D/G/N/S hemagglutinin polymorphisms during the first wave of the 2009 influenza pandemic

(2011) Bin Wang et al.   JOURNAL OF CLINICAL VIROLOGY

Clinical and virological course of infection with haemagglutinin D222G mutant strain of 2009 pandemic influenza A (H1N1) virus

(2011) Paul K.S. Chan et al.   JOURNAL OF CLINICAL VIROLOGY

Cytokine production by primary human macrophages infected with highly pathogenic H5N1 or pandemic H1N1 2009 influenza viruses

(2011) S. Sakabe et al.   JOURNAL OF GENERAL VIROLOGY

Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza

(2011) Jan-Erik Berdal et al.   JOURNAL OF INFECTION

The 2009 Pandemic H1N1 D222G Hemagglutinin Mutation Alters Receptor Specificity and Increases Virulence in Mice but Not in Ferrets

(2011) Yacine Abed et al.   JOURNAL OF INFECTIOUS DISEASES

Avian-Type Receptor-Binding Ability Can Increase Influenza Virus Pathogenicity in Macaques

(2011) T. Watanabe et al.   JOURNAL OF VIROLOGY

Evolutionary Dynamics of Local Pandemic H1N1/2009 Influenza Virus Lineages Revealed by Whole-Genome Analysis

(2011) G. J. Baillie et al.   JOURNAL OF VIROLOGY

Structural Characterization of the Hemagglutinin Receptor Specificity from the 2009 H1N1 Influenza Pandemic

(2011) R. Xu et al.   JOURNAL OF VIROLOGY

Impact of Amino Acid Mutations in PB2, PB1-F2, and NS1 on the Replication and Pathogenicity of Pandemic (H1N1) 2009 Influenza Viruses

(2011) M. Ozawa et al.   JOURNAL OF VIROLOGY

The DBA.2 Mouse Is Susceptible to Disease following Infection with a Broad, but Limited, Range of Influenza A and B Viruses

(2011) N. Pica et al.   JOURNAL OF VIROLOGY

Host genetic background and the innate inflammatory response of lung to influenza virus

(2011) Rita A. Trammell et al.   MICROBES AND INFECTION

Influenza A viruses: new research developments

(2011) Rafael A. Medina et al.   NATURE REVIEWS MICROBIOLOGY

Obesity is associated with higher risk of intensive care unit admission and death in influenza A (H1N1) patients: a systematic review and meta-analysis

(2011) L. Fezeu et al.   Obesity Reviews

The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice

(2011) Michelle D. Tate et al.   PLoS One

A Review of Adult Mortality Due to 2009 Pandemic (H1N1) Influenza A in California

(2011) Janice K. Louie et al.   PLoS One

Genomic Polymorphism of the Pandemic A (H1N1) Influenza Viruses Correlates with Viral Replication, Virulence, and Pathogenicity In Vitro and In Vivo

(2011) Lili Xu et al.   PLoS One

Effect of D222G Mutation in the Hemagglutinin Protein on Receptor Binding, Pathogenesis and Transmissibility of the 2009 Pandemic H1N1 Influenza Virus

(2011) Jessica A. Belser et al.   PLoS One

Infection of Lung Epithelial Cells with Pandemic 2009 A(H1N1) Influenza Viruses Reveals Isolate-Specific Differences in Infectivity and Host Cellular Responses

(2011) Jenish R. Patel et al.   VIRAL IMMUNOLOGY

Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets

(2011) Isabelle Meunier et al.   VIROLOGY

Induction and evasion of type I interferon responses by influenza viruses

(2011) Adolfo García-Sastre   VIRUS RESEARCH

Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis

(2011) Maria D. Van Kerkhove et al.   PLOS MEDICINE

Highly Pathogenic Avian Influenza Virus H5N1 Infects Alveolar Macrophages without Virus Production or Excessive TNF-Alpha Induction

(2011) Debby van Riel et al.   PLoS Pathogens

2009 Pandemic Influenza A (H1N1)

(2010) Wun-Ju Shieh et al.   AMERICAN JOURNAL OF PATHOLOGY

Delayed Clearance of Viral Load and Marked Cytokine Activation in Severe Cases of Pandemic H1N1 2009 Influenza Virus Infection

(2010) Kelvin K. W. To et al.   CLINICAL INFECTIOUS DISEASES

D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

(2010) Andrés Antón et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Epidemiology of influenza-associated hospitalization in adults, Toronto, 2007/8

(2010) S. P. Kuster et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice

(2010) Patrick C Reading et al.   IMMUNOLOGY AND CELL BIOLOGY

Deep Sequencing Reveals Mixed Infection with 2009 Pandemic Influenza A (H1N1) Virus Strains and the Emergence of Oseltamivir Resistance

(2010) Elodie Ghedin et al.   JOURNAL OF INFECTIOUS DISEASES

Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus

(2010) Y. Liu et al.   JOURNAL OF VIROLOGY

Virulence-Associated Substitution D222G in the Hemagglutinin of 2009 Pandemic Influenza A(H1N1) Virus Affects Receptor Binding

(2010) S. Chutinimitkul et al.   JOURNAL OF VIROLOGY

Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin

(2010) H. Mao et al.   JOURNAL OF VIROLOGY

Pandemic Swine-Origin H1N1 Influenza A Virus Isolates Show Heterogeneous Virulence in Macaques

(2010) D. Safronetz et al.   JOURNAL OF VIROLOGY

Adaptation of Pandemic H1N1 Influenza Viruses in Mice

(2010) N. A. Ilyushina et al.   JOURNAL OF VIROLOGY

Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice

(2010) M. D. Tate et al.   JOURNAL OF VIROLOGY

Pathogenesis of Pandemic Influenza A (H1N1) and Triple-Reassortant Swine Influenza A (H1) Viruses in Mice

(2010) J. A. Belser et al.   JOURNAL OF VIROLOGY

Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs

(2010) Pirada Suphaphiphat et al.   Virology Journal

Molecular and phylogenetic analysis of the haemagglutinin gene of pandemic influenza H1N1 2009 viruses associated with severe and fatal infections

(2010) Angeliki Melidou et al.   VIRUS RESEARCH

Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype?

(2010) Jianqiang Ye et al.   PLoS Pathogens

Influenza epidemiology and characterization of influenza viruses in patients seeking treatment for acute fever in Cambodia

(2009) P. J. BLAIR et al.   EPIDEMIOLOGY AND INFECTION

Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans

(2009) J.S. Malik Peiris et al.   JOURNAL OF CLINICAL VIROLOGY

Alterations in receptor-binding properties of swine influenza viruses of the H1 subtype after isolation in embryonated chicken eggs

(2009) N. Takemae et al.   JOURNAL OF GENERAL VIROLOGY

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

(2009) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

Cytokine Profiles Induced by the Novel Swine‐Origin Influenza A/H1N1 Virus: Implications for Treatment Strategies

(2009) Patrick C. Y. Woo et al.   JOURNAL OF INFECTIOUS DISEASES

Pandemic H1N1 2009 Influenza A Virus Induces Weak Cytokine Responses in Human Macrophages and Dendritic Cells and Is Highly Sensitive to the Antiviral Actions of Interferons

(2009) P. Osterlund et al.   JOURNAL OF VIROLOGY

Full genomic amplification and subtyping of influenza A virus using a single set of universal primers

(2009) Emi Inoue et al.   MICROBIOLOGY AND IMMUNOLOGY

Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in China

(2009) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections

(2009) Barkha Srivastava et al.   PLoS One

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

(2009) C. R. Baskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs

(2008) H. M. Kim et al.   JOURNAL OF VIROLOGY

Neutrophils Play an Essential Role in Cooperation with Antibody in both Protection against and Recovery from Pulmonary Infection with Influenza Virus in Mice

(2008) H. Fujisawa   JOURNAL OF VIROLOGY

Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus

(2008) C. Pappas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction

(2008) Nicholas Svitek et al.   VIROLOGY

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens