Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology
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Title
Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology
Authors
Keywords
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Journal
Frontiers in Physiology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-12-12
DOI
10.3389/fphys.2017.00986
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Note: Only part of the references are listed.- A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes
- (2017) Hiroyuki Ando et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- High throughput physiological screening of iPSC-derived cardiomyocytes for drug development
- (2016) Juan C. del Álamo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes
- (2016) Fikru B. Bedada et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?
- (2016) Ross H. Johnstone et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A distribution analysis of action potential parameters obtained from patch-clamped human stem cell-derived cardiomyocytes
- (2016) Fernando López-Redondo et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Uncertainty and variability in computational and mathematical models of cardiac physiology
- (2016) Gary R. Mirams et al. JOURNAL OF PHYSIOLOGY-LONDON
- Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility
- (2016) Ryan A. Devenyi et al. JOURNAL OF PHYSIOLOGY-LONDON
- Induced pluripotent stem cell technology: a decade of progress
- (2016) Yanhong Shi et al. NATURE REVIEWS DRUG DISCOVERY
- Pluripotent stem cells in disease modelling and drug discovery
- (2016) Yishai Avior et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Myokit: A simple interface to cardiac cellular electrophysiology
- (2016) Michael Clerx et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
- (2016) Ksenia Blinova et al. TOXICOLOGICAL SCIENCES
- Simulated micro-electrode array recordings from stem cell-derived cardiomyocytes
- (2016) Louise Bowler et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Cardiac tissue slices: preparation, handling, and successful optical mapping
- (2015) Ken Wang et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Action Potential Morphology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Does Not Predict Cardiac Chamber Specificity and Is Dependent on Cell Density
- (2015) David T.M. Du et al. BIOPHYSICAL JOURNAL
- Human induced pluripotent stem cell-derived versus adult cardiomyocytes: anin silicoelectrophysiological study on effects of ionic current block
- (2015) M Paci et al. BRITISH JOURNAL OF PHARMACOLOGY
- Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes
- (2015) I. Karakikes et al. CIRCULATION RESEARCH
- Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories
- (2015) Hyun Seok Hwang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk
- (2015) Carlos A. Obejero-Paz et al. Scientific Reports
- Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications
- (2015) Anurag Mathur et al. Scientific Reports
- Temporal Trends in Ischemic Heart Disease Mortality in 21 World Regions, 1980 to 2010
- (2014) Andrew E. Moran et al. CIRCULATION
- Measuring the Contractile Forces of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Arrays of Microposts
- (2014) Marita L. Rodriguez et al. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
- Chemically defined generation of human cardiomyocytes
- (2014) Paul W Burridge et al. NATURE METHODS
- Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes
- (2014) Wendy Keung et al. Stem Cell Research & Therapy
- Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium
- (2013) Philip T. Sager et al. AMERICAN HEART JOURNAL
- Computational Models of Ventricular- and Atrial-Like Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
- (2013) Michelangelo Paci et al. ANNALS OF BIOMEDICAL ENGINEERING
- Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity
- (2013) Ping Liang et al. CIRCULATION
- Induced Pluripotent Stem Cell–Derived Cardiomyocytes
- (2013) Björn C. Knollmann CIRCULATION RESEARCH
- Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells
- (2013) Hideyuki Okano et al. CIRCULATION RESEARCH
- Induced pluripotent stem cell–derived cardiomyocytes in studies of inherited arrhythmias
- (2013) Silvia G. Priori et al. JOURNAL OF CLINICAL INVESTIGATION
- Lessons from the heart: Mirroring electrophysiological characteristics during cardiac development to in vitro differentiation of stem cell derived cardiomyocytes
- (2013) Nikki H.L. van den Heuvel et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Small and large animal models in cardiac contraction research: Advantages and disadvantages
- (2013) Nima Milani-Nejad et al. PHARMACOLOGY & THERAPEUTICS
- MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
- (2013) James Kramer et al. Scientific Reports
- Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
- (2013) Ryan C. Elkins et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes
- (2012) Michelangelo Paci et al. Biomedical Engineering Online
- Disease characterization using LQTS-specific induced pluripotent stem cells
- (2012) Toru Egashira et al. CARDIOVASCULAR RESEARCH
- Animal Models of Heart Failure
- (2012) Steven R. Houser et al. CIRCULATION RESEARCH
- Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy
- (2012) Dongrui Ma et al. EUROPEAN HEART JOURNAL
- Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform
- (2012) Antje D. Ebert et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics
- (2012) Cecile Terrenoire et al. JOURNAL OF GENERAL PHYSIOLOGY
- Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia With Patient-Specific Human-Induced Pluripotent Stem Cells
- (2012) Ilanit Itzhaki et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The promise of induced pluripotent stem cells in research and therapy
- (2012) Daisy A. Robinton et al. NATURE
- Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
- (2012) Xiaojun Lian et al. Nature Protocols
- Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations
- (2012) Kirsi Kujala et al. PLoS One
- Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility
- (2012) Adriana Blazeski et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Inter-individual Variability in the Pre-clinical Drug Cardiotoxic Safety Assessment—Analysis of the Age–Cardiomyocytes Electric Capacitance Dependence
- (2012) Sebastian Polak et al. Journal of Cardiovascular Translational Research
- High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents
- (2011) Junyi Ma et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The Physiome Model Repository 2
- (2011) T. Yu et al. BIOINFORMATICS
- Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk
- (2011) Gary R. Mirams et al. CARDIOVASCULAR RESEARCH
- Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines
- (2011) Steven J. Kattman et al. Cell Stem Cell
- In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells
- (2011) Azra Fatima et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
- (2011) Christian B. Jung et al. EMBO Molecular Medicine
- Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
- (2011) Masayuki Yazawa et al. NATURE
- Modelling the long QT syndrome with induced pluripotent stem cells
- (2011) Ilanit Itzhaki et al. NATURE
- Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation
- (2011) Thomas O'Hara et al. PLoS Computational Biology
- Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
- (2010) Alessandra Moretti et al. NEW ENGLAND JOURNAL OF MEDICINE
- Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells
- (2010) Amrita X. Sarkar et al. PLoS Computational Biology
- Markov models for ion channels: versatility versus identifiability and speed
- (2009) M. Fink et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- Absence of Transverse Tubules Contributes to Non-Uniform Ca2+ Wavefronts in Mouse and Human Embryonic Stem Cell–Derived Cardiomyocytes
- (2009) Deborah K. Lieu et al. STEM CELLS AND DEVELOPMENT
- Time to reconsider stem cell ethics--the importance of induced pluripotent cells
- (2008) S. Holm JOURNAL OF MEDICAL ETHICS
- Benchmarking Safety Pharmacology regulatory packages and best practice
- (2008) Silvana Lindgren et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
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