Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

The Unstoppable Attraction for Induced Pluripotent Stem Cells

(2012) Massimiliano Gnecchi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

(2012) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Electrifying iPSC Disease Model: Long QT Syndrome Type 2 and Heart Cells in a Dish

(2011) Timothy J. Kamp   Cell Stem Cell

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines

(2011) Steven J. Kattman et al.   Cell Stem Cell

Modelling Long QT Syndrome With iPS Cells: Be Still, My Beating Heart …

(2011) G. Tiscornia et al.   CIRCULATION RESEARCH

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation

(2011) Atara Novak et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry

(2011) Kai Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

(2011) Masayuki Yazawa et al.   NATURE

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Induced Pluripotent Stem Cells in Long-QT Syndrome

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms

(2011) J. D. Moreno et al.   Science Translational Medicine

Long QT syndrome with compound mutations is associated with a more severe phenotype: A Japanese multicenter study

(2010) Hideki Itoh et al.   HEART RHYTHM

A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome

(2010) K. J. Sampson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette

(2010) Aba Somers et al.   STEM CELLS

Long QT syndrome due to a novel mutation in SCN5A: treatment with ICD placement at 1 month and left cardiac sympathetic denervation at 3 months of age

(2009) Eric S. Silver et al.   JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

Sodium channel mutations and arrhythmias

(2009) Yanfei Ruan et al.   Nature Reviews Cardiology

The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG)

(2008) Moritz F. Sinner et al.   EUROPEAN HEART JOURNAL

Cardiac potassium channel dysfunction in sudden infant death syndrome

(2008) Troy E. Rhodes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette

(2008) Cesar A. Sommer et al.   STEM CELLS