Human induced pluripotent stem cell-derived versus adult cardiomyocytes: anin silicoelectrophysiological study on effects of ionic current block

Selective Na+/Ca2+exchanger inhibition prevents Ca2+overload-induced triggered arrhythmias

(2014) Norbert Nagy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of selective NCX inhibition by ORM-10103 during simulated ischemia/reperfusion

(2014) Anita Kormos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

(2014) Lucia Romero et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Simulation of early after-depolarisation in non-failing human ventricular myocytes: Can this help cardiac safety pharmacology?

(2014) Bernard Christophe   Pharmacological Reports

Population of Computational Rabbit-Specific Ventricular Action Potential Models for Investigating Sources of Variability in Cellular Repolarisation

(2014) Philip Gemmell et al.   PLoS One

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Computational Models of Ventricular- and Atrial-Like Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

(2013) Michelangelo Paci et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Concise Guide to PHARMACOLOGY 2013/14: Transporters

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2013) Björn C. Knollmann   CIRCULATION RESEARCH

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome

(2013) Milena Bellin et al.   EMBO JOURNAL

Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells

(2013) Dongrui Ma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Calcium signalling of human pluripotent stem cell-derived cardiomyocytes

(2013) Sen Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety pharmacology — Current and emerging concepts

(2013) Junnat Hamdam et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology

(2012) Annamaria Carusi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment

(2012) Giovanni Y. Di Veroli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes

(2012) Michelangelo Paci et al.   Biomedical Engineering Online

Drug-induced QT interval prolongation: does ethnicity of the thorough QT study population matter?

(2012) Rashmi R. Shah   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

(2012) Nejib Zemzemi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disease characterization using LQTS-specific induced pluripotent stem cells

(2012) Toru Egashira et al.   CARDIOVASCULAR RESEARCH

Clinical and Genetic Determinants of Torsade de Pointes Risk

(2012) Andrew J. Sauer et al.   CIRCULATION

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

(2012) Cecile Terrenoire et al.   JOURNAL OF GENERAL PHYSIOLOGY

Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia With Patient-Specific Human-Induced Pluripotent Stem Cells

(2012) Ilanit Itzhaki et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations

(2012) Kirsi Kujala et al.   PLoS One

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias

(2012) Maaike Hoekstra et al.   Frontiers in Physiology

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents

(2011) Junyi Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment

(2011) M. R. Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

(2011) A. L. Lahti et al.   Disease Models & Mechanisms

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation

(2011) Elena Matsa et al.   EUROPEAN HEART JOURNAL

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

(2011) Masayuki Yazawa et al.   NATURE

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Systematic characterization of the ionic basis of rabbit cellular electrophysiology using two ventricular models

(2011) Lucía Romero et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: Current recommendations from the Safety Pharmacology Society

(2011) D.J. Leishman et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk

(2010) Esther Pueyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Drug-Induced Arrhythmia

(2010) E. Kevin Heist et al.   CIRCULATION

The Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs

(2010) B Rodriguez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug-Induced Long QT Syndrome

(2010) P. Kannankeril et al.   PHARMACOLOGICAL REVIEWS

Impact of ionic current variability on human ventricular cellular electrophysiology

(2009) Lucía Romero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Na+/Ca2+ Exchanger is a Determinant of Excitation–Contraction Coupling in Human Embryonic Stem Cell–Derived Ventricular Cardiomyocytes

(2009) Ji-Dong Fu et al.   STEM CELLS AND DEVELOPMENT

Slow delayed rectifier K+current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles

(2008) P P-S So et al.   BRITISH JOURNAL OF PHARMACOLOGY

Multiscale modelling of drug-induced effects on cardiac electrophysiological activity

(2008) T. Brennan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES