New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

Dysregulated mTOR-Dependent Signaling in Neurodegeneration or Carcinogenesis: Implication for Alzheimer's Disease and Brain Tumors

(2018) Shan Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The impact of scopolamine pretreatment on 3-iodothyronamine (T1AM) effects on memory and pain in mice

(2017) Annunziatina Laurino et al.   HORMONES AND BEHAVIOR

Thyronamines and Analogues - The Route from Rediscovery to Translational Research on Thyronergic Amines

(2017) Grazia Chiellini et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges

(2017) Mark D. Berry et al.   PHARMACOLOGY & THERAPEUTICS

Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells

(2017) Michela Ferrucci et al.   Oncotarget

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinsons Disease

(2016) Pilar Rivero-Ríos et al.   Current Neuropharmacology

3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors

(2016) Annunziatina Laurino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study

(2016) Grazia Chiellini et al.   JOURNAL OF MEDICINAL CHEMISTRY

The mTOR signalling cascade: paving new roads to cure neurological disease

(2016) Peter B. Crino   Nature Reviews Neurology

Autophagy in acute brain injury

(2016) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Thyronamines and Derivatives: Physiological Relevance, Pharmacological Actions, and Future Research Directions

(2016) Carolin Stephanie Hoefig et al.   THYROID

Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

(2016) Carla Garza-Lombó et al.   Frontiers in Cellular Neuroscience

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

(2016) Keiichiro Minatohara et al.   Frontiers in Molecular Neuroscience

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications

(2016) Yue Pei et al.   Frontiers in Neuroscience

3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice

(2015) Annunziatina Laurino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells

(2015) Noushafarin Khajavi et al.   CELLULAR SIGNALLING

In-vivo pharmacology of Trace-Amine Associated Receptor 1

(2015) Vincent M. Lam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine

(2015) Annunziatina Laurino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers

(2015) Anja Harmeier et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Recent advances in autophagy-based neuroprotection

(2015) Khaled Radad et al.   Expert Review of Neurotherapeutics

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists

(2015) Grazia Chiellini et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-iodothyronamine differentially modulates  -2A-adrenergic receptor-mediated signaling

(2015) J. Dinter et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Recent advances in autophagy-based neuroprotection

(2015) Khaled Radad et al.   Expert Review of Neurotherapeutics

Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace Amine-Associated Receptor 5

(2015) Juliane Dinter et al.   PLoS One

Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

(2014) Claudia Musilli et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Update on 3-iodothyronamine and its neurological and metabolic actions

(2014) Riccardo Zucchi et al.   Frontiers in Physiology

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

(2013) Sovan Sarkar   BIOCHEMICAL SOCIETY TRANSACTIONS

The Concise Guide to PHARMACOLOGY 2013/14: Overview

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The roles of protein kinases in learning and memory

(2013) K. P. Giese et al.   LEARNING & MEMORY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care

(2013) Ludwig Trillo et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Rapamycin inhibits the growth of glioblastoma

(2012) Antonietta Arcella et al.   BRAIN RESEARCH

3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice

(2012) Maria Elena Manni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold

(2012) Maria Elena Manni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Avenues for the Development of Therapeutics That Target Trace Amine Associated Receptor 1 (TAAR1)

(2012) Gregory M. Miller   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of ERK2 phosphorylation by histamine in splenocytes

(2011) Radhika D. Dandekar et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes

(2011) Michael W. Panas et al.   Journal of Neuroimmune Pharmacology

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Autophagy for tissue homeostasis and neuroprotection

(2010) Guillermo Mariño et al.   CURRENT OPINION IN CELL BIOLOGY

Tissue Distribution and Cardiac Metabolism of 3-Iodothyronamine

(2010) Alessandro Saba et al.   ENDOCRINOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Autophagy basics

(2010) Isei Tanida   MICROBIOLOGY AND IMMUNOLOGY

The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system

(2009) A. Bradaia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Iodothyronamines are Oxidatively Deaminated to Iodothyroacetic Acids in vivo

(2008) Warren J. L. Wood et al.   CHEMBIOCHEM

3-Iodothyronamine (T1AM): A New Player on the Thyroid Endocrine Team?

(2008) Thomas S. Scanlan   ENDOCRINOLOGY

The Thyroid-Brain Interaction in Thyroid Disorders and Mood Disorders

(2008) M. Bauer et al.   JOURNAL OF NEUROENDOCRINOLOGY