Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

(2016) Zachary Freyberg et al.   Nature Communications

Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter

(2015) Maarten E.A. Reith et al.   DRUG AND ALCOHOL DEPENDENCE

In-vivo pharmacology of Trace-Amine Associated Receptor 1

(2015) Vincent M. Lam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers

(2015) Anja Harmeier et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Evidence against dopamine D1/D2 receptor heteromers

(2015) A L Frederick et al.   MOLECULAR PSYCHIATRY

Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1

(2015) Stefano Espinoza et al.   NEUROPHARMACOLOGY

Targeting β-arrestin2 in the treatment of l-DOPA–induced dyskinesia in Parkinson’s disease

(2015) Nikhil M. Urs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds

(2015) Yue Pei et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects

(2015) Rachel Cotter et al.   Frontiers in Neuroscience

Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Behavioral Indices of Methamphetamine in Rats

(2015) L. Jing et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

TAAR1-dependent effects of apomorphine in mice

(2014) Ilya Sukhanov et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: Role of D2 dopamine autoreceptors

(2014) D. Leo et al.   NEUROPHARMACOLOGY

Activation of the Trace Amine-Associated Receptor 1 Prevents Relapse to Cocaine Seeking

(2014) Yui Pei et al.   NEUROPSYCHOPHARMACOLOGY

The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats

(2014) David A. Thorn et al.   NEUROSCIENCE LETTERS

Vesicular Monoamine Transporter 2 and the Acute and Long-Term Response to 3,4-(±)-Methylenedioxymethamphetamine

(2014) Lucina E. Lizarraga et al.   TOXICOLOGICAL SCIENCES

Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking

(2012) Clara Velázquez-Sánchez et al.   ADDICTION BIOLOGY

Neural Mechanisms of Reward in Insects

(2012) Clint J. Perry et al.   Annual Review of Entomology

Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics

(2012) Florent G. Revel et al.   BIOLOGICAL PSYCHIATRY

A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight

(2012) F G Revel et al.   MOLECULAR PSYCHIATRY

Novel nondopaminergic targets for motor features of Parkinson's disease: Review of recent trials

(2012) Lorraine V. Kalia et al.   MOVEMENT DISORDERS

Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists

(2012) Takato Hiranita et al.   NEUROPSYCHOPHARMACOLOGY

Brain-Specific Overexpression of Trace Amine-Associated Receptor 1 Alters Monoaminergic Neurotransmission and Decreases Sensitivity to Amphetamine

(2012) Florent G Revel et al.   NEUROPSYCHOPHARMACOLOGY

Deletion of GSK3  in D2R-expressing neurons reveals distinct roles for  -arrestin signaling in antipsychotic and lithium action

(2012) N. M. Urs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AKT/GSK3 signaling pathway and schizophrenia

(2012) Effat S. Emamian   Frontiers in Molecular Neuroscience

Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes

(2011) Michael W. Panas et al.   Journal of Neuroimmune Pharmacology

Genetic Deletion of Trace Amine 1 Receptors Reveals Their Role in Auto-Inhibiting the Actions of Ecstasy (MDMA)

(2011) B. Di Cara et al.   JOURNAL OF NEUROSCIENCE

Functional Interaction between Trace Amine-Associated Receptor 1 and Dopamine D2 Receptor

(2011) S. Espinoza et al.   MOLECULAR PHARMACOLOGY

Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1

(2011) Cindy Achat-Mendes et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

(2011) F. G. Revel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond cAMP: the regulation of Akt and GSK3 by dopamine receptors

(2011) Jean-Martin Beaulieu   Frontiers in Molecular Neuroscience

Trace amines depress D2-autoreceptor-mediated responses on midbrain dopaminergic cells

(2010) Ada Ledonne et al.   BRITISH JOURNAL OF PHARMACOLOGY

All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors

(2010) Philip Seeman   CNS Neuroscience & Therapeutics

The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization

(2010) C. Velázquez-Sánchez et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity

(2010) Gregory M. Miller   JOURNAL OF NEUROCHEMISTRY

GSK-3β activity and hyperdopamine-dependent behaviors

(2010) Yan-Chun Li et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Trace amine-associated receptor 1 as a monoaminergic modulator in brain

(2009) Zhihua Xie et al.   BIOCHEMICAL PHARMACOLOGY

Antipsychotic-Induced Extrapyramidal Side Effects in Bipolar Disorder and Schizophrenia

(2009) Keming Gao et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

A Receptor Mechanism for Methamphetamine Action in Dopamine Transporter Regulation in Brain

(2009) Z. Xie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Dopamine Uptake Inhibitor 3α-[bis(4′-fluorophenyl)metoxy]-tropane Reduces Cocaine-Induced Early-Gene Expression, Locomotor Activity and Conditioned Reward

(2009) Clara Velázquez-Sánchez et al.   NEUROPSYCHOPHARMACOLOGY

Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity

(2009) B.M. Geiger et al.   NEUROSCIENCE

The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system

(2009) A. Bradaia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat

(2009) Antonio Ferragud et al.   PSYCHOPHARMACOLOGY

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

(2008) Jean-Martin Beaulieu et al.   Annual Review of Pharmacology and Toxicology

Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in Human Embryonic Kidney 293 Cells and Brain Synaptosomes

(2008) Z. Xie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

 -Phenylethylamine Alters Monoamine Transporter Function via Trace Amine-Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain

(2008) Z. Xie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor

(2008) L. S. Barak et al.   MOLECULAR PHARMACOLOGY

Whole-genome association study of bipolar disorder

(2008) P Sklar et al.   MOLECULAR PSYCHIATRY

Neurobiological substrates for the dark side of compulsivity in addiction

(2008) George F. Koob   NEUROPHARMACOLOGY

Trace amine associated receptor 1 and movement control

(2008) Tatyana D. Sotnikova et al.   PARKINSONISM & RELATED DISORDERS

Antagonism of dopamine D2 receptor/ -arrestin 2 interaction is a common property of clinically effective antipsychotics

(2008) B. Masri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction

(2007) Richard B. Rothman et al.   BIOCHEMICAL PHARMACOLOGY

Monoamine transporters and psychostimulant addiction

(2007) Leonard L. Howell et al.   BIOCHEMICAL PHARMACOLOGY