Recent advances in autophagy-based neuroprotection

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

1,25-Dyhydroxyvitamin D3 attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy

(2014) Wooyoung Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Is Alzheimer's disease a systemic disease?

(2014) Jill K. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells

(2014) Hee Ju Kim et al.   Biomolecules & Therapeutics

Can Trehalose Prevent Neurodegeneration? Insights from Experimental Studies

(2014) Enzo Emanuele   CURRENT DRUG TARGETS

The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy

(2014) Constanza J. Cortes et al.   DRUG DISCOVERY TODAY

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of Huntingtin

(2014) D. D. O. Martin et al.   HUMAN MOLECULAR GENETICS

Regulation by mitophagy

(2014) Nobutaka Hattori et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Resveratrol Partially Prevents Rotenone-Induced Neurotoxicity in Dopaminergic SH-SY5Y Cells through Induction of Heme Oxygenase-1 Dependent Autophagy

(2014) Tsu-Kung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model

(2014) Hyun Jung Park et al.   NEUROBIOLOGY OF AGING

Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity

(2014) Matthias Höllerhage et al.   NEUROBIOLOGY OF AGING

Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

(2014) Teng Jiang et al.   PHARMACOLOGICAL RESEARCH

Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington's Disease Patients Caused by Proteosome Inhibition

(2014) Maria Angeles Fernandez-Estevez et al.   PLoS One

Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance

(2014) Jin Zhou et al.   PLoS One

Loss of PINK1 Impairs Stress-Induced Autophagy and Cell Survival

(2014) Dajana Parganlija et al.   PLoS One

Dysfunctional autophagy in Alzheimer’s disease: pathogenic roles and therapeutic implications

(2014) Jun-Hua Liang et al.   Neuroscience Bulletin

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model

(2013) John W. Steele et al.   Autophagy

The role of autophagy in Parkinson's disease: rotenone-based modeling

(2013) Nian Xiong et al.   Behavioral and Brain Functions

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect

(2013) Niloufar Ansari et al.   Current Neuropharmacology

The significance of macroautophagy in health and disease

(2013) C. Tukaj   FOLIA MORPHOLOGICA

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

(2013) M. L. Hebron et al.   HUMAN MOLECULAR GENETICS

Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells

(2013) An-Guo Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes

(2013) Javier Pacheco-Quinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term mTOR inhibitors administration evokes altered calcium homeostasis and platelet dysfunction in kidney transplant patients

(2013) Esther López et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

(2013) Tian-Fang Jiang et al.   Journal of Neuroimmune Pharmacology

Autophagy Modulation for Alzheimer’s Disease Therapy

(2013) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy

(2013) Chen-Chen Tan et al.   NEUROBIOLOGY OF AGING

Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase

(2013) Yudong Liu et al.   NEUROCHEMISTRY INTERNATIONAL

The V471A Polymorphism in Autophagy-Related Gene ATG7 Modifies Age at Onset Specifically in Italian Huntington Disease Patients

(2013) Silke Metzger et al.   PLoS One

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

(2013) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Effects of Conversion From Cyclosporine to Rapamycin on Testicular Function and Morphology in a Rat Transplantation Model

(2013) Z. He et al.   TRANSPLANTATION PROCEEDINGS

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes

(2012) Lei-lei Chen et al.   ACTA PHARMACOLOGICA SINICA

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

(2012) Ozlem Oral et al.   APOPTOSIS

Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage

(2012) Jing Han et al.   Autophagy

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

(2012) V Pagliarini et al.   CELL DEATH AND DIFFERENTIATION

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: protective effects of rapamycin

(2012) Almas Siddiqui et al.   FREE RADICAL RESEARCH

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

(2012) L. Gan et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

(2012) Zhiyou Cai et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   JOURNAL OF PINEAL RESEARCH

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein

(2012) Dan-Mei Lan et al.   NEUROCHEMICAL RESEARCH

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

(2012) Kangyong Liu et al.   NEUROCHEMICAL RESEARCH

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROSCIENCE RESEARCH

Autophagy During Vertebrate Development

(2012) María R. Aburto et al.   Cells

Neuronal Autophagy: A Housekeeper or a Fighter in Neuronal Cell Survival?

(2012) Jin-A Lee   Experimental Neurobiology

A critical role for UVRAG in apoptosis

(2011) Xiaocheng Yin et al.   Autophagy

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

(2011) N Deblon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

(2011) Assaf D. Rubinstein et al.   MOLECULAR CELL

Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology

(2011) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Sirolimus Therapy Predisposes to New-Onset Diabetes Mellitus After Renal Transplantation: A Long-Term Analysis of Various Treatment Regimens

(2011) E. Gyurus et al.   TRANSPLANTATION PROCEEDINGS

Autophagy and apoptosis: what is the connection?

(2011) Jacob M. Gump et al.   TRENDS IN CELL BIOLOGY

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

Autophagy for tissue homeostasis and neuroprotection

(2010) Guillermo Mariño et al.   CURRENT OPINION IN CELL BIOLOGY

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway

(2010) Bi-Yin Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

(2010) Giuseppe Filomeni et al.   NEUROBIOLOGY OF AGING

Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1α and induction of autophagy in SH-SY5Y cells

(2010) Yuncheng Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Parkinson's disease involves autophagy and abnormal distribution of cathepsin L

(2010) Lingyun Li et al.   NEUROSCIENCE LETTERS

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications

(2010) Rebecca Banerjee et al.   TRENDS IN NEUROSCIENCES

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL

(2009) Einat Zalckvar et al.   Autophagy

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Amyloid β and APP as biomarkers for Alzheimer’s disease

(2009) Henrik Zetterberg et al.   EXPERIMENTAL GERONTOLOGY

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

(2009) Philipp A Jaeger et al.   Molecular Neurodegeneration

FLIP-mediated autophagy regulation in cell death control

(2009) Jong-Soo Lee et al.   NATURE CELL BIOLOGY

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling

Parkinson-Linked Genes and Toxins That Affect Neuronal Cell Death Through the Bcl-2 Family

(2008) Douglas W. Ethell et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration

(2008) Sharon A Tooze et al.   CURRENT OPINION IN NEUROBIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

(2008) Tianhong Pan et al.   NEUROBIOLOGY OF DISEASE

Autophagy Is Essential for Preimplantation Development of Mouse Embryos

(2008) S. Tsukamoto et al.   SCIENCE