A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease

Protein–protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches

(2013) Armand G. Ngounou Wetie et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance

(2013) Boxun Lu et al.   NATURE NEUROSCIENCE

Inositol polyphosphate multikinase signaling in the regulation of metabolism

(2012) Joo-Young Lee et al.   Annals of the New York Academy of Sciences

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65

(2012) Wan Ning Vanessa Chow et al.   BIOCHEMICAL JOURNAL

ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling

(2012) Jun Qin et al.   CURRENT OPINION IN CELL BIOLOGY

Repulsive axon guidance cues ephrin-A2 and slit3 stop protrusion of the growth cone leading margin concurrently with inhibition of ADF/cofilin and ERM proteins

(2012) Bonnie M. Marsick et al.   Cytoskeleton

Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes

(2012) Janina E. Borgonovo et al.   EXPERIMENTAL NEUROLOGY

Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis

(2012) Brady P. Culver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nerve Growth Factor-Induced Formation of Axonal Filopodia and Collateral Branches Involves the Intra-Axonal Synthesis of Regulators of the Actin-Nucleating Arp2/3 Complex

(2012) M. Spillane et al.   JOURNAL OF NEUROSCIENCE

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Evolution and function of CAG/polyglutamine repeats in protein–protein interaction networks

(2012) Martin H. Schaefer et al.   NUCLEIC ACIDS RESEARCH

A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis

(2012) Shuqiu Zheng et al.   Molecular Brain

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

(2012) John P. Miller et al.   PLoS Genetics

Ezrin, Radixin and Moesin: key regulators of membrane–cortex interactions and signaling

(2011) Amanda L Neisch et al.   CURRENT OPINION IN CELL BIOLOGY

From filopodia to synapses: the role of actin-capping and anti-capping proteins

(2011) Elisabetta Menna et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA)

(2011) Ya-Jun Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What have we learned from gene expression profiles in Huntington's disease?

(2011) Tamara Seredenina et al.   NEUROBIOLOGY OF DISEASE

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

(2010) Ming-Chang Chiang et al.   HUMAN MOLECULAR GENETICS

A human MAP kinase interactome

(2010) Sourav Bandyopadhyay et al.   NATURE METHODS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

(2010) John P. Miller et al.   NEURON

CDD: a Conserved Domain Database for the functional annotation of proteins

(2010) A. Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks

(2010) Javier De Las Rivas et al.   PLoS Computational Biology

Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells

(2009) Tamara Ratovitski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Rho Kinases Enhances the Degradation of Mutant Huntingtin

(2009) Peter O. Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism between 14-3-3 Binding and SH3-Mediated Localization

(2009) J. M. Robens et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrin-linked kinase is an adaptor with essential functions during mouse development

(2009) Anika Lange et al.   NATURE

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

I-BAR domains, IRSp53 and filopodium formation

(2009) Sohail Ahmed et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Subcellular membrane curvature mediated by the BAR domain superfamily proteins

(2009) Shiro Suetsugu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species

(2009) Russell Bell et al.   PLoS Genetics

ROCK and PRK-2 mediate the inhibitory effect of Y-27632 on polyglutamine aggregation

(2008) Jieya Shao et al.   FEBS LETTERS

The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics

(2008) Kim Buay Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity

(2008) A. L. Southwell et al.   JOURNAL OF NEUROSCIENCE

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Protein Reference Database--2009 update

(2008) T. S. Keshava Prasad et al.   NUCLEIC ACIDS RESEARCH

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE