Journal
JOURNAL OF NEUROSCIENCE
Volume 31, Issue 45, Pages 16045-16048Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4006-11.2011
Keywords
-
Categories
Funding
- Israel Science Foundation
- German-Israeli Foundation
- Minerva Foundation
- International Foundation for Research in Paraplegia
- Christopher and Dana Reeve Foundation
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- NIH [R01 NS063228, R01 MH091662, R01 NS050674]
- Center for Brain and Behavior Sciences Magdeburg
- Deutsche Forschungsgemeinschaft
- Bundesministerium fur Bildung und Forschung
- DZNE Magdeburg
- Deutsche-Israelische Projektkooperation
- Leibniz Foundation (Pakt fur Forschung)
- Schram Foundation
Ask authors/readers for more resources
How do neurons integrate intracellular communication from synapse to nucleus and back? Here we briefly summarize aspects of this topic covered by a symposium at Neuroscience 2011. A rich repertoire of signaling mechanisms link both dendritic terminals and axon tips with neuronal soma and nucleus, using motor-dependent transport machineries to traverse the long intracellular distances along neuronal processes. Activation mechanisms at terminals include localized translation of dendritic or axonal RNA, proteolytic cleavage of receptors or second messengers, and differential phosphorylation of signaling moieties. Signaling complexes may be transported in endosomes, or as non-endosomal complexes associated with importins and dynein. Anterograde transport of RNA granules from the soma to neuronal processes, coupled with retrograde transport of proteins translated locally at terminals or within processes, may fuel ongoing bidirectional communication between soma and synapse to modulate synaptic plasticity as well as neuronal growth and survival decisions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available