Possible modification of Alzheimer’s disease by statins in midlife: interactions with genetic and non-genetic risk factors
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Possible modification of Alzheimer’s disease by statins in midlife: interactions with genetic and non-genetic risk factors
Authors
Keywords
-
Journal
Frontiers in Aging Neuroscience
Volume 6, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2014-04-23
DOI
10.3389/fnagi.2014.00071
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease
- (2018) Abhay P. Sagare et al. JOURNAL OF ALZHEIMERS DISEASE
- Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology
- (2017) Stuart Bennett et al. JOURNAL OF ALZHEIMERS DISEASE
- Changes in Cognition and Amyloid-β Processing with Long Term Cholesterol Reduction using Atorvastatin in Aged Dogs
- (2017) M. Paul Murphy et al. JOURNAL OF ALZHEIMERS DISEASE
- Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stressin amyloid β injection mouse model
- (2014) Hitomi Kurinami et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- 2013 Alzheimer's disease facts and figures
- (2013) Alzheimers & Dementia
- The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
- (2013) Michael W. Weiner et al. Alzheimers & Dementia
- Deletion of Abca7 Increases Cerebral Amyloid- Accumulation in the J20 Mouse Model of Alzheimer's Disease
- (2013) W. S. Kim et al. JOURNAL OF NEUROSCIENCE
- Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
- (2013) Clifford R Jack et al. LANCET NEUROLOGY
- Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
- (2013) J Chapuis et al. MOLECULAR PSYCHIATRY
- Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
- (2013) Masahiro Maruyama et al. NEURON
- Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
- (2013) Ana Griciuc et al. NEURON
- The Effect of HMG-CoA Reductase Inhibitors on Cognition in Patients With Alzheimer's Dementia: A Prospective Withdrawal and Rechallenge Pilot Study
- (2012) Kalpana P. Padala et al. American Journal Geriatric Pharmacotherapy
- Is Statin-Associated Cognitive Impairment Clinically Relevant? A Narrative Review and Clinical Recommendations
- (2012) Carlos H Rojas-Fernandez et al. ANNALS OF PHARMACOTHERAPY
- Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
- (2012) M. Yarchoan et al. BRAIN
- Is RAGE still a therapeutic target for Alzheimer’s disease?
- (2012) Richard J Deane Future Medicinal Chemistry
- Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis
- (2012) Qingli Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-
- (2012) T. Kanekiyo et al. JOURNAL OF NEUROSCIENCE
- Age-Dependent Rescue by Simvastatin of Alzheimer's Disease Cerebrovascular and Memory Deficits
- (2012) X.-K. Tong et al. JOURNAL OF NEUROSCIENCE
- Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain
- (2012) Tomoko Kurata et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and Therapy
- (2012) Jin-Tai Yu et al. MOLECULAR NEUROBIOLOGY
- Statins in the prevention of dementia and Alzheimer's disease: A meta-analysis of observational studies and an assessment of confounding
- (2012) William B. Wong et al. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
- Cholesterol Level and Statin Use in Alzheimer Disease
- (2011) Nina E. Shepardson ARCHIVES OF NEUROLOGY
- HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7
- (2011) Nobukiyo Tanaka et al. ATHEROSCLEROSIS
- Complement receptor 1 (CR1) and Alzheimer's disease
- (2011) Helen Crehan et al. IMMUNOBIOLOGY
- Roles of ATP-Binding Cassette Transporter A7 in Cholesterol Homeostasis and Host Defense System
- (2011) Nobukiyo Tanaka et al. Journal of Atherosclerosis and Thrombosis
- Statins, Risk of Dementia, and Cognitive Function: Secondary Analysis of the Ginkgo Evaluation of Memory Study
- (2011) Kerstin Bettermann et al. Journal of Stroke & Cerebrovascular Diseases
- Alzheimer's disease
- (2011) Clive Ballard et al. LANCET
- Apolipoprotein E in Alzheimer's disease and other neurological disorders
- (2011) Philip B Verghese et al. LANCET NEUROLOGY
- Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function
- (2011) Shuko Takeda et al. Molecular BioSystems
- The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease
- (2011) Aaron J. Trachtenberg et al. NEUROBIOLOGY OF AGING
- A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
- (2011) M. Sano et al. NEUROLOGY
- Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
- (2011) S. Debette et al. NEUROLOGY
- Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders
- (2011) D. Allan Butterfield et al. PHARMACOLOGICAL RESEARCH
- Effects of Simvastatin on Cholesterol Metabolism and Alzheimer Disease Biomarkers
- (2010) Alberto Serrano-Pozo et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy
- (2010) Domenico Praticò Annals of the New York Academy of Sciences
- The Revitalized Tau Hypothesis on Alzheimer's Disease
- (2010) Ricardo B. Maccioni et al. ARCHIVES OF MEDICAL RESEARCH
- Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease
- (2010) Christiane Reitz et al. ARCHIVES OF NEUROLOGY
- Alterations of cholesterol precursor levels in Alzheimer's disease
- (2010) Heike Kölsch et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Pleiotropic Effects of Statins
- (2010) Qian Zhou et al. CIRCULATION JOURNAL
- Soluble RAGE-Modulating Drugs: State-of-the-Art and Future Perspectives for Targeting Vascular Inflammation
- (2010) Niccolo Lanati et al. Current Vascular Pharmacology
- Type 2 Diabetes and Cognitive Decline in Middle-Aged Men and Women: The Doetinchem Cohort Study
- (2010) A. C. J. Nooyens et al. DIABETES CARE
- Lowering Midlife Levels of Systolic Blood Pressure as a Public Health Strategy to Reduce Late-Life Dementia
- (2010) Lenore J. Launer et al. HYPERTENSION
- Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion
- (2010) Irfan Y. Tamboli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance
- (2010) Mitsuru Shinohara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroinflammatory processes in Alzheimer’s disease
- (2010) Michael T. Heneka et al. JOURNAL OF NEURAL TRANSMISSION
- Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early-Onset Form (Type I) and Demyelination in Late-Onset Form (Type II)
- (2010) Lars Svennerholm et al. JOURNAL OF NEUROCHEMISTRY
- Cholesterol-Lowering Interventions and Stroke
- (2010) Raffaele De Caterina et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Age-Varying Association Between Statin Use and Incident Alzheimer's Disease
- (2010) Ge Li et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
- (2010) Naveed Sattar et al. LANCET
- Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
- (2010) H. H. Feldman et al. NEUROLOGY
- Decreased Clearance of CNS -Amyloid in Alzheimer's Disease
- (2010) K. G. Mawuenyega et al. SCIENCE
- Are NSAIDs useful to treat Alzheimer’s disease or mild cognitive impairment?
- (2010) Imbimbo Frontiers in Aging Neuroscience
- Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy
- (2009) Roy O. Weller et al. ACTA NEUROPATHOLOGICA
- Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease
- (2009) Robert D. Bell et al. ACTA NEUROPATHOLOGICA
- A Randomized, Double-blind, Placebo Controlled-trial of Triflusal in Mild Cognitive Impairment
- (2009) Teresa Gómez-Isla et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- Cholesterol as a Risk Factor for Dementia and Cognitive Decline: A Systematic Review of Prospective Studies With Meta-Analysis
- (2009) Kaarin J. Anstey et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
- (2009) John C. Morris et al. ANNALS OF NEUROLOGY
- The LDL Receptor
- (2009) Joseph L. Goldstein et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Mild cholesterol depletion reduces amyloid-β production by impairing APP trafficking to the cell surface
- (2009) Cristina Guardia-Laguarta et al. JOURNAL OF NEUROCHEMISTRY
- Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy
- (2009) Moran Boimel et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention
- (2009) Pierre Amarenco et al. LANCET NEUROLOGY
- Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
- (2009) Clifford R Jack et al. LANCET NEUROLOGY
- Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
- (2009) Guojun Bu NATURE REVIEWS NEUROSCIENCE
- The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis
- (2009) Nick M. Wisdom et al. NEUROBIOLOGY OF AGING
- Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice
- (2009) Xin-Kang Tong et al. NEUROBIOLOGY OF DISEASE
- Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients
- (2009) Gunter P. Eckert et al. NEUROBIOLOGY OF DISEASE
- Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort
- (2009) J.C.S. Breitner et al. NEUROLOGY
- Statin-Associated Adverse Cognitive Effects: Survey Results from 171 Patients
- (2009) Marcella A Evans et al. PHARMACOTHERAPY
- Diabetes and the Risk of Multi-System Aging Phenotypes: A Systematic Review and Meta-Analysis
- (2009) Feng-Ping Lu et al. PLoS One
- Fibrillar amyloid- burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
- (2009) E. M. Reiman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distinct patterns of brain activity in young carriers of the APOE- 4 allele
- (2009) N. Filippini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease
- (2008) Dietmar Rudolf Thal et al. ACTA NEUROPATHOLOGICA
- Cognitive and Cerebral Metabolic Effects of Celecoxib Versus Placebo in People With Age-Related Memory Loss: Randomized Controlled Study
- (2008) Gary W. Small et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Reduced Risk of Incident AD with Elective Statin Use in a Clinical Trial Cohort
- (2008) D. Sparks et al. Current Alzheimer Research
- Apolipoprotein E Knockout Models
- (2008) Genovefa Kolovou et al. CURRENT PHARMACEUTICAL DESIGN
- Lovastatin inhibits amyloid precursor protein (APP) β-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts
- (2008) Je-Seong Won et al. JOURNAL OF NEUROCHEMISTRY
- Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
- (2008) M D M Haag et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: a meta-analysis
- (2008) LANCET
- Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
- (2008) Clive Holmes et al. LANCET
- Alzheimer's disease: on the verges of treatment and prevention
- (2008) Alistair Burns LANCET NEUROLOGY
- A gift from nature: the birth of the statins
- (2008) Akira Endo NATURE MEDICINE
- Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
- (2008) Z. Arvanitakis et al. NEUROLOGY
- Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
- (2008) Scott A. Small et al. NEURON
- Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis
- (2008) M. A. Beydoun et al. Obesity Reviews
- Dose-dependent effect of rosuvastatin on apolipoprotein B-100 kinetics in the metabolic syndrome
- (2007) Esther M.M. Ooi et al. ATHEROSCLEROSIS
- Geranylgeranyl pyrophosphate stimulates γ-secretase to increase the generation of Aβ and APP-CTFγ
- (2007) Yan Zhou et al. FASEB JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More