APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins

FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation

(2017) Paul Strecker et al.   Scientific Reports

Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores

(2016) Z. Elaib et al.   BLOOD

Expression and localization of X11 family proteins in neurons

(2016) Rika Motodate et al.   BRAIN RESEARCH

Nuclear spheres modulate the expression of BEST1 and GADD45G

(2016) Christina Loosse et al.   CELLULAR SIGNALLING

Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein

(2016) Christopher J. R. Dunning et al.   JOURNAL OF NEUROCHEMISTRY

Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration

(2016) Jenna M. Ramaker et al.   JOURNAL OF NEUROSCIENCE

APP Receptor? To Be or Not To Be

(2016) Carole Deyts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Canonical and Non-canonical Reelin Signaling

(2016) Hans H. Bock et al.   Frontiers in Cellular Neuroscience

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

(2016) Poomy Pandey et al.   Oncotarget

Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse

(2016) Erica Tagliatti et al.   eLife

The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury

(2016) Stephanie Plummer et al.   Aging and Disease

Analysis of Amyloid Precursor Protein Function in Drosophila melanogaster

(2016) Marlène Cassar et al.   Frontiers in Molecular Neuroscience

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes

(2015) Wen-Jie Bian et al.   CELL

FE65: Roles beyond amyloid precursor protein processing

(2015) Wan Ning Vanessa Chow et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

FE65 and FE65L1 amyloid precursor protein–binding protein compound null mice display adult-onset cataract and muscle weakness

(2015) Jaehong Suh et al.   FASEB JOURNAL

ADP-ribosylation Factor 6 (ARF6) Bidirectionally Regulates Dendritic Spine Formation Depending on Neuronal Maturation and Activity

(2015) Yoonju Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Full-Length Form of the Drosophila Amyloid Precursor Protein Is Involved in Memory Formation

(2015) I. Bourdet et al.   JOURNAL OF NEUROSCIENCE

The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior

(2015) M. Klevanski et al.   JOURNAL OF NEUROSCIENCE

Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP

(2015) Arpita Kundu et al.   MOLECULAR NEUROBIOLOGY

An epigenomic role of Fe65 in the cellular response to DNA damage

(2015) Seungjin Ryu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination

(2015) Liang Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development

(2015) Chan Choo Yap et al.   Frontiers in Cellular Neuroscience

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

(2015) Weihao Tang et al.   Molecular Brain

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

Scaffold Protein X11α Interacts with Kalirin-7 in Dendrites and Recruits It to Golgi Outposts

(2014) Kelly A. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-induced Homotypic and Heterotypic Clustering of Apolipoprotein E Receptor 2

(2014) Shailaja D. Divekar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mint Proteins Are Required for Synaptic Activity-dependent Amyloid Precursor Protein (APP) Trafficking and Amyloid β Generation

(2014) Sarah E. Sullivan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calsyntenin-1 Regulates Targeting of Dendritic NMDA Receptors and Dendritic Spine Maturation in CA1 Hippocampal Pyramidal Cells during Postnatal Development

(2014) J. Ster et al.   JOURNAL OF NEUROSCIENCE

Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain

(2014) F. Baumkotter et al.   JOURNAL OF NEUROSCIENCE

Differential role of APP and APLPs for neuromuscular synaptic morphology and function

(2014) Maja Klevanski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Ryanodine receptors: physiological function and deregulation in Alzheimer disease

(2014) Dolores Del Prete et al.   Molecular Neurodegeneration

Shedding of APP limits its synaptogenic activity and cell adhesion properties

(2014) Ronny Stahl et al.   Frontiers in Cellular Neuroscience

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

(2014) N Milosch et al.   Cell Death & Disease

Calsyntenins Function as Synaptogenic Adhesion Molecules in Concert with Neurexins

(2014) Ji Won Um et al.   Cell Reports

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

Systematic Evaluation of Candidate Ligands Regulating Ectodomain Shedding of Amyloid Precursor Protein

(2013) Heather C. Rice et al.   BIOCHEMISTRY

Synaptic vesicle protein 2A: basic facts and role in synaptic function

(2013) Julieta Griselda Mendoza-Torreblanca et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians

(2013) Ewa Golanska et al.   EXPERIMENTAL GERONTOLOGY

FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth

(2013) Hei Nga Maggie Cheung et al.   FASEB JOURNAL

Recruitment of the Mint3 Adaptor Is Necessary for Export of the Amyloid Precursor Protein (APP) from the Golgi Complex

(2013) Amanda H. Caster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble amyloid-  precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans

(2013) C. Reinhard et al.   JOURNAL OF CELL SCIENCE

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

AGAP3 and Arf6 Regulate Trafficking of AMPA Receptors and Synaptic Plasticity

(2013) Y. Oku et al.   JOURNAL OF NEUROSCIENCE

X11/Mint Genes Control Polarized Localization of Axonal Membrane Proteins in Vivo

(2013) G. G. Gross et al.   JOURNAL OF NEUROSCIENCE

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

Dab1 Is Required for Synaptic Plasticity and Associative Learning

(2013) J. Trotter et al.   JOURNAL OF NEUROSCIENCE

Amyloid Beta A4 Precursor Protein-binding Family B Member 1 (FE65) Interactomics Revealed Synaptic Vesicle Glycoprotein 2A (SV2A) and Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 (SERCA2) as New Binding Proteins in the Human Brain

(2013) Fabian M. Nensa et al.   MOLECULAR & CELLULAR PROTEOMICS

The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development

(2013) Katherine L. Pettem et al.   NEURON

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice

(2013) Hong Y Choi et al.   eLife

Notch signaling and neural connectivity

(2012) Edward Giniger   CURRENT OPINION IN GENETICS & DEVELOPMENT

Fe65 matters: New light on an old molecule

(2012) Giuseppina Minopoli et al.   IUBMB LIFE

Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function

(2012) Brea Midthune et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

FE65 as a link between VLDLR and APP to regulate their trafficking and processing

(2012) Sonya B Dumanis et al.   Molecular Neurodegeneration

GULP1 is a novel APP-interacting protein that alters APP processing

(2011) Candy Yan Hao et al.   BIOCHEMICAL JOURNAL

Amyloid Precursor Protein Binding Protein Fe65 Is Cleaved by Caspases during DNA Damage-Induced Apoptosis

(2011) Kazunori Saeki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The extracellular region of Lrp4 is sufficient to mediate neuromuscular synapse formation

(2011) Andrea M. Gomez et al.   DEVELOPMENTAL DYNAMICS

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function

(2011) Alessia P. M. Barbagallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Revisited

(2011) Qinxi Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform

(2011) Sara Catarina Domingues et al.   JOURNAL OF NEUROCHEMISTRY

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production

(2011) Megumi Asada-Utsugi et al.   JOURNAL OF NEUROCHEMISTRY

The physiology of the β-amyloid precursor protein intracellular domain AICD

(2011) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF NEUROCHEMISTRY

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Not(ch) just development: Notch signalling in the adult brain

(2011) Jessica L. Ables et al.   NATURE REVIEWS NEUROSCIENCE

Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks

(2011) Lavinia Alberi et al.   NEURON

Functional and molecular interactions between Rac1 and FE65

(2011) Pi-Lin Wang et al.   NEUROREPORT

Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like

(2011) Yuhki Saito et al.   PLoS One

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural aspects and physiological consequences of APP/APLP trans-dimerization

(2011) Frederik Baumkötter et al.   EXPERIMENTAL BRAIN RESEARCH

Functions of the APP gene family in the nervous system: insights from mouse models

(2011) Dorothee Aydin et al.   EXPERIMENTAL BRAIN RESEARCH

Synaptic organizing complexes

(2010) Tabrez J Siddiqui et al.   CURRENT OPINION IN NEUROBIOLOGY

Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis

(2010) Hongmei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-type dependent modulation of Notch signaling by the amyloid precursor protein

(2010) Sun Young Oh et al.   JOURNAL OF NEUROCHEMISTRY

The amyloid precursor protein intracellular domain (AICD) disrupts actin dynamics and mitochondrial bioenergetics

(2010) Manus W. Ward et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role - relevance for Alzheimer pathology

(2010) Gennaro Schettini et al.   JOURNAL OF NEUROCHEMISTRY

Megalin interacts with APP and the intracellular adapter protein FE65 in neurons

(2010) Ximena Alvira-Botero et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

AMPA Receptor Signaling through BRAG2 and Arf6 Critical for Long-Term Synaptic Depression

(2010) Ralf Scholz et al.   NEURON

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

The multiple functions of Numb

(2009) Alberto Gulino et al.   EXPERIMENTAL CELL RESEARCH

X11-Like Protein Deficiency Is Associated with Impaired Conflict Resolution in Mice

(2009) Y. Sano et al.   JOURNAL OF NEUROSCIENCE

Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

(2009) H.-S. Hoe et al.   JOURNAL OF NEUROSCIENCE

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation

(2009) Y. Wang et al.   LEARNING & MEMORY

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

(2009) Robert Tamayev et al.   Molecular Neurodegeneration

Dysregulation of Calcium Homeostasis in Alzheimer’s Disease

(2009) David H. Small   NEUROCHEMICAL RESEARCH

Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism

(2009) Ana M. Claasen et al.   NEUROSCIENCE LETTERS

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

(2008) Jens Radzimanowski et al.   EMBO REPORTS

The X11L/X11β/MINT2 and X11L2/X11γ/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm

(2008) Akio Sumioka et al.   EXPERIMENTAL CELL RESEARCH

Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription

(2008) E WALDRON et al.   EXPERIMENTAL CELL RESEARCH

Crystal Structure of the Human Fe65-PTB1 Domain

(2008) Jens Radzimanowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X11 Proteins Regulate the Translocation of Amyloid β-Protein Precursor (APP) into Detergent-resistant Membrane and Suppress the Amyloidogenic Cleavage of APP by β-Site-cleaving Enzyme in Brain

(2008) Yuhki Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Numb Endocytic Adapter Proteins Regulate the Transport and Processing of the Amyloid Precursor Protein in an Isoform-dependent Manner

(2008) George A. Kyriazis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect β-Secretase Cleavage of APP

(2008) Daniela Kaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch1 Signaling in Pyramidal Neurons Regulates Synaptic Connectivity and Experience-Dependent Modifications of Acuity in the Visual Cortex

(2008) M. Dahlhaus et al.   JOURNAL OF NEUROSCIENCE

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex

(2008) Kazue Hashimoto-Torii et al.   NEURON

Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity

(2008) Jyothi Arikkath et al.   TRENDS IN NEUROSCIENCES

A genetic interaction between the APP and Dab1 genes influences brain development

(2007) Albéna Pramatarova et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mint3/X11γ Is an ADP-Ribosylation Factor-dependent Adaptor that Regulates the Traffic of the Alzheimer's Precursor Protein from the Trans-Golgi Network

(2007) Punya Shrivastava-Ranjan et al.   MOLECULAR BIOLOGY OF THE CELL