Shedding of APP limits its synaptogenic activity and cell adhesion properties

Beyond pathology: APP, brain development and Alzheimer's disease

(2014) Alessia Soldano et al.   CURRENT OPINION IN NEUROBIOLOGY

Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain

(2014) F. Baumkotter et al.   JOURNAL OF NEUROSCIENCE

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development

(2013) Katherine L. Pettem et al.   NEURON

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

Synaptic Cell Adhesion

(2012) M. Missler et al.   Cold Spring Harbor Perspectives in Biology

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Structural aspects and physiological consequences of APP/APLP trans-dimerization

(2011) Frederik Baumkötter et al.   EXPERIMENTAL BRAIN RESEARCH

Analysis of amyloid precursor protein function in Drosophila melanogaster

(2011) Burkhard Poeck et al.   EXPERIMENTAL BRAIN RESEARCH

Synaptic organizing complexes

(2010) Tabrez J Siddiqui et al.   CURRENT OPINION IN NEUROBIOLOGY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

(2010) S. O. Dahms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

(2009) Kristin T. Jacobsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production

(2009) Simone Eggert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2

(2009) D. Kaden et al.   JOURNAL OF CELL SCIENCE

Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

(2009) H.-S. Hoe et al.   JOURNAL OF NEUROSCIENCE

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β–Anti-Amyloid-β Complex Structure Reveals an Extended Conformation in the Immunodominant B-Cell Epitope

(2008) Luke A. Miles et al.   JOURNAL OF MOLECULAR BIOLOGY

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function

(2008) Katia Carmine-Simmen et al.   NEUROBIOLOGY OF DISEASE