The G2 checkpoint-a node-based molecular switch

MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation

(2016) Po Yee Wong et al.   Scientific Reports

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle

(2015) I. A. Shaltiel et al.   JOURNAL OF CELL SCIENCE

Spatial Separation of Plk1 Phosphorylation and Activity

(2015) Wytse Bruinsma et al.   Frontiers in Oncology

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing

(2014) Hongqing Liang et al.   Nature Communications

PP2ACdc55regulates G1cyclin stability

(2013) Paula McCourt et al.   CELL CYCLE

Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit

(2013) Stela S. Palii et al.   CELL CYCLE

Ubiquitylation-dependent localization of PLK1 in mitosis

(2013) Jochen Beck et al.   NATURE CELL BIOLOGY

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

(2013) H. Christian Reinhardt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cks confers specificity to phosphorylation-dependent CDK signaling pathways

(2013) Denise A McGrath et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription-replication encounters, consequences and genomic instability

(2013) Anne Helmrich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation

(2013) B. T. Hughes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?

(2012) Hidemasa Goto et al.   CANCER SCIENCE

Spatial Positive Feedback at the Onset of Mitosis

(2012) Silvia D.M. Santos et al.   CELL

MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells

(2012) Julien Villeneuve et al.   EMBO JOURNAL

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres

(2012) Maria Thanasoula et al.   EMBO JOURNAL

Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation

(2012) Sara Ovejero et al.   MOLECULAR BIOLOGY OF THE CELL

P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

(2012) Ping Li et al.   MOLECULAR BIOLOGY OF THE CELL

The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells

(2012) H. J. Landau et al.   MOLECULAR CANCER THERAPEUTICS

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

(2012) Rodrigo Bermejo et al.   MOLECULAR CELL

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery

(2012) J P H Chow et al.   ONCOGENE

Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1

(2012) Marieke Aarts et al.   Cancer Discovery

Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy

(2011) Heekyoung Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe

(2011) P. C. De Witt Hamer et al.   CLINICAL CANCER RESEARCH

Coupling of T161 and T14 phosphorylations protects cyclin B–CDK1 from premature activation

(2011) Katia Coulonval et al.   MOLECULAR BIOLOGY OF THE CELL

Ultrasensitivity in the Regulation of Cdc25C by Cdk1

(2011) Nicole B. Trunnell et al.   MOLECULAR CELL

How APC/C–Cdc20 changes its substrate specificity in mitosis

(2011) Daisuke Izawa et al.   NATURE CELL BIOLOGY

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphatases: providing safe passage through mitotic exit

(2011) Claudia Wurzenberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

(2011) C. S. Sorensen et al.   NUCLEIC ACIDS RESEARCH

Checkpoint control and cancer

(2011) R H Medema et al.   ONCOGENE

Contributions Made by CDC25 Phosphatases to Proliferation of Intestinal Epithelial Stem and Progenitor Cells

(2011) Gwanghee Lee et al.   PLoS One

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage

(2010) Luigi Carlessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma

(2010) Shahryar E. Mir et al.   CANCER CELL

Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2Checkpoint and Inhibition of Homologous Recombinational DNA Repair

(2010) Meredith A. Morgan et al.   CANCER RESEARCH

Hsp90 phosphorylation, Wee1 and the cell cycle

(2010) Mehdi Mollapour et al.   CELL CYCLE

14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

(2010) Kousuke Kasahara et al.   EMBO JOURNAL

Activation of cyclin B1–Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

(2010) Olivier Gavet et al.   JOURNAL OF CELL BIOLOGY

Quantitative Reconstitution of Mitotic CDK1 Activation in Somatic Cell Extracts

(2010) Richard W. Deibler et al.   MOLECULAR CELL

Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

(2010) Mehdi Mollapour et al.   MOLECULAR CELL

Protein phosphatase 2A has an essential role in the activation of γ-irradiation-induced G2/M checkpoint response

(2010) Y Yan et al.   ONCOGENE

Identification of a nuclear localization signal in the polo box domain of Plk1

(2009) Moon-Sing Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G2/M Transition

(2009) Masato Enomoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Mitotic phosphatases: from entry guards to exit guides

(2009) Mathieu Bollen et al.   TRENDS IN CELL BIOLOGY

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

(2008) S. D. Zabludoff et al.   MOLECULAR CANCER THERAPEUTICS

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

The regulatory β-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis

(2008) C W Yde et al.   ONCOGENE

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

(2008) Veerle Janssens et al.   TRENDS IN BIOCHEMICAL SCIENCES