Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit

ATM and DNA-PKcs make a complementary couple in DNA double strand break repair

(2012) M. Martín et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation

(2011) Kurtis D. Davies et al.   CANCER BIOLOGY & THERAPY

Unleashing Chk1 in cancer therapy

(2011) Laura Carrassa et al.   CELL CYCLE

Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition

(2011) L. A. Parsels et al.   CLINICAL CANCER RESEARCH

CHK1 Inhibitors in Combination Chemotherapy: Thinking Beyond the Cell Cycle

(2011) P. Dent et al.   MOLECULAR INTERVENTIONS

Single-Agent Inhibition of Chk1 Is Antiproliferative in Human Cancer Cell Lines In Vitro and Inhibits Tumor Xenograft Growth In Vivo

(2011) Kurtis D. Davies et al.   ONCOLOGY RESEARCH

Anticancer therapy with checkpoint inhibitors: what, where and when?

(2011) Michelle D. Garrett et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo

(2010) Y. Dai et al.   BLOOD

Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2Checkpoint and Inhibition of Homologous Recombinational DNA Repair

(2010) Meredith A. Morgan et al.   CANCER RESEARCH

Phosphatases in the cellular response to DNA damage

(2010) Alyson K Freeman et al.   Cell Communication and Signaling

Radiosensitization by Chir-124, a selective Chk1 inhibitor: Effects of p53 and cell cycle checkpoints

(2010) Yungan Tao et al.   CELL CYCLE

Targeting Chk1 in the replicative stress response

(2010) Yun Dai et al.   CELL CYCLE

Mitotic DNA damage response: Polo-like Kinase-1 is dephosphorylated through ATM-Chk1 pathway

(2010) Hee-Jae Lee et al.   CELL CYCLE

Collaboration and competition between DNA double-strand break repair pathways

(2010) Elizabeth M. Kass et al.   FEBS LETTERS

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery

(2010) Kyungsoo Ha et al.   HUMAN MOLECULAR GENETICS

Mre11 Nuclease Activity and Ctp1 Regulate Chk1 Activation by Rad3ATR and Tel1ATM Checkpoint Kinases at Double-Strand Breaks

(2010) O. Limbo et al.   MOLECULAR AND CELLULAR BIOLOGY

Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1

(2010) Mary E. Gagou et al.   MOLECULAR BIOLOGY OF THE CELL

Protein phosphatase 2A has an essential role in the activation of γ-irradiation-induced G2/M checkpoint response

(2010) Y Yan et al.   ONCOGENE

Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53

(2010) T Fishler et al.   ONCOGENE

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

(2010) Cynthia X. Ma et al.   TRENDS IN MOLECULAR MEDICINE

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation

(2009) K R Greenow et al.   ONCOGENE

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

(2008) N Bucher et al.   BRITISH JOURNAL OF CANCER

DNA Protein Kinase Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells

(2008) S. J.H. Arlander et al.   CANCER RESEARCH

Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

(2008) Midori Shimada et al.   CELL

Expanded Roles for Chk1 in Genome Maintenance

(2008) Greg H. Enders   JOURNAL OF BIOLOGICAL CHEMISTRY