Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion

Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders

(2016) Mingyan Lin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

(2016) B. B. Lake et al.   SCIENCE

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

(2016) Aaron Topol et al.   Cell Reports

A survey of human brain transcriptome diversity at the single cell level

(2015) Spyros Darmanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Building models for postmortem abnormalities in hippocampus of schizophrenics

(2015) Francine M. Benes   SCHIZOPHRENIA RESEARCH

GABAergic mechanisms of hippocampal hyperactivity in schizophrenia

(2015) Stephan Heckers et al.   SCHIZOPHRENIA RESEARCH

CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

(2015) Ping Wang et al.   Molecular Autism

Transcriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and Autism Spectrum Disorder

(2015) Maria Jalbrzikowski et al.   PLoS One

MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del

(2015) Dejian Zhao et al.   PLoS One

Transcriptional Consequences of 16p11.2 Deletion and Duplication in Mouse Cortex and Multiplex Autism Families

(2014) Ian Blumenthal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cutting Edge: MHC Class I-Ly49 Interaction Regulates Neuronal Function

(2014) O. Zohar et al.   JOURNAL OF IMMUNOLOGY

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

(2014) Anthony H V Schapira et al.   LANCET

Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci

(2014) O A Andreassen et al.   MOLECULAR PSYCHIATRY

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

(2014) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

CORTECON: A Temporal Transcriptome Analysis of In Vitro Human Cerebral Cortex Development from Human Embryonic Stem Cells

(2014) Joyce van de Leemput et al.   NEURON

Heat Shock Alters the Expression of Schizophrenia and Autism Candidate Genes in an Induced Pluripotent Stem Cell Model of the Human Telencephalon

(2014) Mingyan Lin et al.   PLoS One

Early Developmental Disturbances of Cortical Inhibitory Neurons: Contribution to Cognitive Deficits in Schizophrenia

(2014) D. W. Volk et al.   SCHIZOPHRENIA BULLETIN

Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia

(2014) Dilafruz Juraeva et al.   PLoS Genetics

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

(2013) Suleyman Gulsuner et al.   CELL

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

(2013) A. Jeremy Willsey et al.   CELL

Microglia: Key Elements in Neural Development, Plasticity, and Pathology

(2013) Ukpong B. Eyo et al.   Journal of Neuroimmune Pharmacology

Reduced Adult Hippocampal Neurogenesis and Working Memory Deficits in the Dgcr8-Deficient Mouse Model of 22q11.2 Deletion-Associated Schizophrenia Can Be Rescued by IGF2

(2013) Y. Ouchi et al.   JOURNAL OF NEUROSCIENCE

Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naïve first-episode schizophrenia patients

(2013) Patricia Gassó et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Markers of apoptotic dysfunctions in schizophrenia

(2013) A. S. Boyajyan et al.   MOLECULAR BIOLOGY

Enhanced survival of lung tissue-resident memory CD8+ T cells during infection with influenza virus due to selective expression of IFITM3

(2013) Linda M Wakim et al.   NATURE IMMUNOLOGY

Transcriptome Comparison of Human Neurons Generated Using Induced Pluripotent Stem Cells Derived from Dental Pulp and Skin Fibroblasts

(2013) Jian Chen et al.   PLoS One

iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls

(2013) Daria Prilutsky et al.   TRENDS IN MOLECULAR MEDICINE

Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

(2013) Yong-Hong Zhang et al.   Nature Communications

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Genome-Wide Association Study Implicates HLA-C*01:02 as a Risk Factor at the Major Histocompatibility Complex Locus in Schizophrenia

(2012)   BIOLOGICAL PSYCHIATRY

The Urokinase Receptor in the Central Nervous System

(2012) Marco Archinti et al.   CNS & Neurological Disorders-Drug Targets

Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer

(2012) Suchitra Muenthaisong et al.   EXPERIMENTAL CELL RESEARCH

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

DiGeorge Syndrome Critical Region 8 (DGCR8) Protein-mediated microRNA Biogenesis Is Essential for Vascular Smooth Muscle Cell Development in Mice

(2012) Zixuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative analysis of cardiomyocyte differentiation from human embryonic stem cells under 3-D and 2-D culture conditions

(2012) Rajarshi Pal et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Two gene co-expression modules differentiate psychotics and controls

(2012) C Chen et al.   MOLECULAR PSYCHIATRY

IFITM3 restricts the morbidity and mortality associated with influenza

(2012) Aaron R. Everitt et al.   NATURE

Functional Gene-Expression Analysis Shows Involvement of Schizophrenia-Relevant Pathways in Patients with 22q11 Deletion Syndrome

(2012) Nico J. M. van Beveren et al.   PLoS One

Allele-Biased Expression in Differentiating Human Neurons: Implications for Neuropsychiatric Disorders

(2012) Mingyan Lin et al.   PLoS One

The atypical 16p11.2 deletion: A not so atypical microdeletion syndrome?

(2011) Daniela Q.C.M. Barge-Schaapveld et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Altered Cell Cycle Dynamics in Schizophrenia

(2011) Yongjun Fan et al.   BIOLOGICAL PSYCHIATRY

The Human Brain in a Dish: The Promise of iPSC-Derived Neurons

(2011) Ricardo Dolmetsch et al.   CELL

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Abnormal Activity of the MAPK- and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia

(2011) Adam J Funk et al.   NEUROPSYCHOPHARMACOLOGY

RNA-Seq of Human Neurons Derived from iPS Cells Reveals Candidate Long Non-Coding RNAs Involved in Neurogenesis and Neuropsychiatric Disorders

(2011) Mingyan Lin et al.   PLoS One

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Lamina-Specific Alterations in Cortical GABAA Receptor Subunit Expression in Schizophrenia

(2010) Monica Beneyto et al.   CEREBRAL CORTEX

Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia

(2010) A. Torkamani et al.   GENOME RESEARCH

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

(2010) Maria Karayiorgou et al.   NATURE REVIEWS NEUROSCIENCE

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation

(2009) Orla Cunningham et al.   GLIA

The Transition from Radial Glial to Intermediate Progenitor Cell Is Inhibited by FGF Signaling during Corticogenesis

(2009) W. Kang et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia is associated with an increase in cortical microRNA biogenesis

(2009) N J Beveridge et al.   MOLECULAR PSYCHIATRY

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function

(2009) P R Maycox et al.   MOLECULAR PSYCHIATRY

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Heterogeneity in the developmental potential of motor neuron progenitors revealed by clonal analysis of single cells in vitro

(2009) Dritan Agalliu et al.   Neural Development

MHC Class I: An Unexpected Role in Neuronal Plasticity

(2009) Carla J. Shatz   NEURON

Fgf10 Regulates Transition Period of Cortical Stem Cell Differentiation to Radial Glia Controlling Generation of Neurons and Basal Progenitors

(2009) Setsuko Sahara et al.   NEURON

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome

(2009) D. W. Meechan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

(2009) S. H. Fatemi et al.   SCHIZOPHRENIA BULLETIN

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Chromosome 22q11.2 Deletion Syndrome: DiGeorge Syndrome/Velocardiofacial Syndrome

(2008) Kathleen E. Sullivan   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

(2008) I. S. Samuels et al.   JOURNAL OF NEUROSCIENCE

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

(2008) Kimberly L Stark et al.   NATURE GENETICS

Abnormal Indices of Cell Cycle Activity in Schizophrenia and their Potential Association with Oligodendrocytes

(2008) Pavel Katsel et al.   NEUROPSYCHOPHARMACOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

(2008) M. Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schizophrenia Susceptibility Genes Directly Implicated in the Life Cycles of Pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and Toxoplasma gondii

(2008) C.J. Carter   SCHIZOPHRENIA BULLETIN

Gene Regulation in the Third Dimension

(2008) J. Dekker   SCIENCE

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Schizophrenia and 22q11.2 deletion syndrome

(2008) Anne S. Bassett et al.   Current Psychiatry Reports

Functional Polymorphisms in PRODH Are Associated with Risk and Protection for Schizophrenia and Fronto-Striatal Structure and Function

(2008) Lucas Kempf et al.   PLoS Genetics

Innervation and activity dependent dynamics of postsynaptic oxidative metabolism

(2007) H. Kazama et al.   NEUROSCIENCE

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

(2003) J. David Sweatt   JOURNAL OF NEUROCHEMISTRY