CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells
出版年份 2017 全文链接
标题
CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells
作者
关键词
DLX6-AS1, Distal-less homeobox, Gabaergic, Cancer, Autism, Schizophrenia, Bipolar disorder, TCF4, HMGA2, ZNF132, Wnt, Beta-catenin
出版物
Molecular Autism
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-03-11
DOI
10.1186/s13229-017-0124-1
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Dysregulated ErbB4 Splicing in Schizophrenia: Selective Effects on Parvalbumin Expression
- (2016) Daniel W. Chung et al. AMERICAN JOURNAL OF PSYCHIATRY
- Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion
- (2016) Mingyan Lin et al. BMC Systems Biology
- The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism
- (2016) Ezzat Hashemi et al. CEREBRAL CORTEX
- Epigenetic Treatment of Neuropsychiatric Disorders: Autism and Schizophrenia
- (2016) Walter H. Moos et al. DRUG DEVELOPMENT RESEARCH
- Identification of novel genetic causes of Rett syndrome-likephenotypes
- (2016) Fátima Lopes et al. JOURNAL OF MEDICAL GENETICS
- Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells
- (2016) Maud de Dieuleveult et al. NATURE
- Near-optimal probabilistic RNA-seq quantification
- (2016) Nicolas L Bray et al. NATURE BIOTECHNOLOGY
- Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling
- (2016) Omer Durak et al. NATURE NEUROSCIENCE
- Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development
- (2016) Giuliana Caronia-Brown et al. Neural Development
- The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance
- (2016) Jonathan H. Teichroeb et al. RNA Biology
- Autism and Cancer Share Risk Genes, Pathways, and Drug Targets
- (2016) Jacqueline N. Crawley et al. TRENDS IN GENETICS
- RELN Mutations in Autism Spectrum Disorder
- (2016) Dawn B. Lammert et al. Frontiers in Cellular Neuroscience
- Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling
- (2016) Ya Wen et al. PLoS One
- Exonic deletions ofAUTS2in Chinese patients with developmental delay and intellectual disability
- (2015) Yanjie Fan et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- De novo exon 1 deletion ofAUTS2gene in a patient with autism spectrum disorder and developmental delay: A case report and a brief literature review
- (2015) Yi Liu et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia
- (2015) Guillermo Gonzalez-Burgos et al. BIOLOGICAL PSYCHIATRY
- Genetic Risk for Schizophrenia: Convergence on Synaptic Pathways Involved in Plasticity
- (2015) Jeremy Hall et al. BIOLOGICAL PSYCHIATRY
- Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice
- (2015) Paola A. Spadaro et al. BIOLOGICAL PSYCHIATRY
- Skating on thin ice: pragmatic prescribing for medication refractory schizophrenia
- (2015) Derek K. Tracy et al. BMC Psychiatry
- CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling
- (2015) Yunliang Wang et al. CANCER LETTERS
- FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
- (2015) Jessica Mariani et al. CELL
- Mood Stabilizers in Children and Adolescents With Autism Spectrum Disorders
- (2015) Roberto Canitano CLINICAL NEUROPHARMACOLOGY
- Evf2lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling
- (2015) Ivelisse Cajigas et al. DEVELOPMENT
- Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics
- (2015) M Alda MOLECULAR PSYCHIATRY
- Common genetic variants influence human subcortical brain structures
- (2015) Derrek P. Hibar et al. NATURE
- Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
- (2015) Jerome Mertens et al. NATURE
- Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells
- (2015) Juanjuan Zhu et al. PLoS One
- The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment
- (2015) Justin Cotney et al. Nature Communications
- CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment
- (2015) Ping Wang et al. Molecular Autism
- The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes
- (2015) B Wilkinson et al. Translational Psychiatry
- A molecular model for neurodevelopmental disorders
- (2015) C O Gigek et al. Translational Psychiatry
- Altered Gene Expression in Schizophrenia: Findings from Transcriptional Signatures in Fibroblasts and Blood
- (2015) Nadia Cattane et al. PLoS One
- The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues
- (2015) Lukasz Michal Szafron et al. PLoS One
- ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin
- (2015) Jian Chen et al. PLoS One
- MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del
- (2015) Dejian Zhao et al. PLoS One
- Molecular Convergence of Neurodevelopmental Disorders
- (2014) Elizabeth S. Chen et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders
- (2014) Dalila Pinto et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Reelin gene variants and risk of autism spectrum disorders: An integrated meta-analysis
- (2014) Zhenling Wang et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Prevalence of Autism Spectrum Disorder symptoms in children with neurofibromatosis type 1
- (2014) Ellen Plasschaert et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development
- (2014) Raphael Bernier et al. CELL
- Deregulation of an imprinted gene network in prostate cancer
- (2014) Teodora Ribarska et al. Epigenetics
- Preliminary Investigation of Lithium for Mood Disorder Symptoms in Children and Adolescents with Autism Spectrum Disorder
- (2014) Matthew Siegel et al. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
- Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing
- (2014) Claire Redin et al. JOURNAL OF MEDICAL GENETICS
- De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
- (2014) S E McCarthy et al. MOLECULAR PSYCHIATRY
- Synaptic, transcriptional and chromatin genes disrupted in autism
- (2014) Silvia De Rubeis et al. NATURE
- An AUTS2–Polycomb complex activates gene expression in the CNS
- (2014) Zhonghua Gao et al. NATURE
- The contribution of de novo coding mutations to autism spectrum disorder
- (2014) Ivan Iossifov et al. NATURE
- Heat Shock Alters the Expression of Schizophrenia and Autism Candidate Genes in an Induced Pluripotent Stem Cell Model of the Human Telencephalon
- (2014) Mingyan Lin et al. PLoS One
- CHD8regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors
- (2014) Aarathi Sugathan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lithium and GSK-3β promoter gene variants influence cortical gray matter volumes in bipolar disorder
- (2014) Francesco Benedetti et al. PSYCHOPHARMACOLOGY
- The emerging roles of TCF4 in disease and development
- (2014) Marc P. Forrest et al. TRENDS IN MOLECULAR MEDICINE
- A de novo convergence of autism genetics and molecular neuroscience
- (2014) Niklas Krumm et al. TRENDS IN NEUROSCIENCES
- Genome-wide association study reveals two new risk loci for bipolar disorder
- (2014) Thomas W. Mühleisen et al. Nature Communications
- DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics
- (2014) Li Liu et al. Molecular Autism
- Frequent Disruption of Chromodomain Helicase DNA-Binding Protein 8 (CHD8) and Functionally Associated Chromatin Regulators in Prostate Cancer
- (2014) Nathan A. Damaschke et al. NEOPLASIA
- Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression
- (2013) Kai-hua Lu et al. BMC CANCER
- Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism
- (2013) A. Jeremy Willsey et al. CELL
- Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes
- (2013) E. G. Berghoff et al. DEVELOPMENT
- Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia
- (2013) Adam R. Cole FEBS Journal
- Colorectal Carcinomas With CpG Island Methylator Phenotype 1 Frequently Contain Mutations in Chromatin Regulators
- (2013) Tomomitsu Tahara et al. GASTROENTEROLOGY
- Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel
- (2013) Mine S. Cicek et al. HUMAN MOLECULAR GENETICS
- Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
- (2013) Ilaria Guella et al. JOURNAL OF PSYCHIATRIC RESEARCH
- The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis
- (2013) Shi-Yan Ng et al. MOLECULAR CELL
- The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing
- (2013) G Barry et al. MOLECULAR PSYCHIATRY
- Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway
- (2013) J Iafrati et al. MOLECULAR PSYCHIATRY
- Cerebral organoids model human brain development and microcephaly
- (2013) Madeline A. Lancaster et al. NATURE
- The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes
- (2013) Alicia Subtil-Rodríguez et al. NUCLEIC ACIDS RESEARCH
- Knockdown of Human TCF4 Affects Multiple Signaling Pathways Involved in Cell Survival, Epithelial to Mesenchymal Transition and Neuronal Differentiation
- (2013) Marc P. Forrest et al. PLoS One
- Transcriptome Comparison of Human Neurons Generated Using Induced Pluripotent Stem Cells Derived from Dental Pulp and Skin Fibroblasts
- (2013) Jian Chen et al. PLoS One
- ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines
- (2012) Hiroyoshi Iseki et al. CANCER SCIENCE
- Replication of GWAS-identified neuroblastoma risk loci strengthens the role of BARD1 and affirms the cumulative effect of genetic variations on disease susceptibility
- (2012) Mario Capasso et al. CARCINOGENESIS
- Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries
- (2012) Michael E. Talkowski et al. CELL
- GENCODE: The reference human genome annotation for The ENCODE Project
- (2012) J. Harrow et al. GENOME RESEARCH
- Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants
- (2012) Bei Wang et al. JOURNAL OF COMPARATIVE NEUROLOGY
- MEG3 noncoding RNA: a tumor suppressor
- (2012) Yunli Zhou et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia
- (2012) Dagmar Denk et al. LEUKEMIA RESEARCH
- Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia
- (2012) M J Green et al. MOLECULAR PSYCHIATRY
- Modeling psychiatric disorders at the cellular and network levels
- (2012) K J Brennand et al. MOLECULAR PSYCHIATRY
- Patterns and rates of exonic de novo mutations in autism spectrum disorders
- (2012) Benjamin M. Neale et al. NATURE
- Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
- (2012) Brian J. O’Roak et al. NATURE
- Common variants at 12q15 and 12q24 are associated with infant head circumference
- (2012) H Rob Taal et al. NATURE GENETICS
- Identification of common variants associated with human hippocampal and intracranial volumes
- (2012) Jason L Stein et al. NATURE GENETICS
- The involvement of Reelin in neurodevelopmental disorders
- (2012) Timothy D. Folsom et al. NEUROPHARMACOLOGY
- Decreased Reelin Expression in the Left Prefrontal Cortex (BA9) in Chronic Schizophrenia Patients
- (2012) Gregor Habl et al. NEUROPSYCHOBIOLOGY
- Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks
- (2012) Xingli Guo et al. NUCLEIC ACIDS RESEARCH
- Modeling human cortical development in vitro using induced pluripotent stem cells
- (2012) J. Mariani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional Corneal Endothelium Derived from Corneal Stroma Stem Cells of Neural Crest Origin by Retinoic Acid and Wnt/β-Catenin Signaling
- (2012) Shin Hatou et al. STEM CELLS AND DEVELOPMENT
- Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
- (2011) M. N. Cabili et al. GENES & DEVELOPMENT
- Genetic and expressional alterations of CHD genes in gastric and colorectal cancers
- (2011) Min Sung Kim et al. HISTOPATHOLOGY
- Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis
- (2011) Mette Opstrup Abildgaard et al. INTERNATIONAL JOURNAL OF CANCER
- Synaptic Wnt signaling—a contributor to major psychiatric disorders?
- (2011) Nathan D. Okerlund et al. Journal of Neurodevelopmental Disorders
- Wnt5a Is a Transcriptional Target of Dlx Homeogenes and Promotes Differentiation of Interneuron Progenitors In Vitro and In Vivo
- (2011) S. Paina et al. JOURNAL OF NEUROSCIENCE
- Histone H1 Recruitment by CHD8 Is Essential for Suppression of the Wnt- -Catenin Signaling Pathway
- (2011) M. Nishiyama et al. MOLECULAR AND CELLULAR BIOLOGY
- Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets
- (2011) E Kwon et al. MOLECULAR PSYCHIATRY
- Modelling schizophrenia using human induced pluripotent stem cells
- (2011) Kristen J. Brennand et al. NATURE
- Genome-wide association study identifies five new schizophrenia loci
- (2011) NATURE GENETICS
- Molecular regulation of telomerase activity in aging
- (2011) Craig Nicholls et al. Protein & Cell
- Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain
- (2010) Magdalena M. Brzózka et al. BIOLOGICAL PSYCHIATRY
- An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain
- (2010) L. Poitras et al. DEVELOPMENT
- Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
- (2010) H. J. Williams et al. HUMAN MOLECULAR GENETICS
- β-Catenin Promoter ChIP-Chip Reveals Potential Schizophrenia and Bipolar Disorder Gene Network
- (2010) Erika Pedrosa et al. JOURNAL OF NEUROGENETICS
- Reelin Regulates Postnatal Neurogenesis and Enhances Spine Hypertrophy and Long-Term Potentiation
- (2010) L. Pujadas et al. JOURNAL OF NEUROSCIENCE
- Direct conversion of fibroblasts to functional neurons by defined factors
- (2010) Thomas Vierbuchen et al. NATURE
- GSK3 signalling in neural development
- (2010) Eun-Mi Hur et al. NATURE REVIEWS NEUROSCIENCE
- lncRNAdb: a reference database for long noncoding RNAs
- (2010) Paulo P. Amaral et al. NUCLEIC ACIDS RESEARCH
- Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2
- (2010) A. A. Scott-Van Zeeland et al. Science Translational Medicine
- Distinct Roles for Wnt-4 and Wnt-11 During Retinoic Acid-Induced Neuronal Differentiation
- (2010) Carina Elizalde et al. STEM CELLS
- Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling
- (2009) Yingwei Mao et al. CELL
- Lithium Pharmacodynamics and Pharmacogenetics: Focus on Inositol Mono Phosphatase (IMPase), Inositol Poliphosphatase (IPPase) and Glycogen Sinthase Kinase 3 Beta (GSK-3 Beta)
- (2009) Alessandro Serretti et al. CURRENT MEDICINAL CHEMISTRY
- Maternally Expressed Gene 3 (MEG3) Noncoding Ribonucleic Acid: Isoform Structure, Expression, and Functions
- (2009) Xun Zhang et al. ENDOCRINOLOGY
- Correlation of mRNA and protein in complex biological samples
- (2009) Tobias Maier et al. FEBS LETTERS
- CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis
- (2009) Masaaki Nishiyama et al. NATURE CELL BIOLOGY
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene
- (2008) Maricela Alarcón et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A Common Genetic Variant in the Neurexin Superfamily Member CNTNAP2 Increases Familial Risk of Autism
- (2008) Dan E. Arking et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Progressive loss of PAX6, TBR2, NEUROD and TBR1 mRNA gradients correlates with translocation of EMX2 to the cortical plate during human cortical development
- (2008) Nadhim Bayatti et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Adjunctive lithium and anticonvulsants for the treatment of schizophrenia: what is the evidence?
- (2008) Leslie Citrome Expert Review of Neurotherapeutics
- TCF4Deletions in Pitt-Hopkins Syndrome
- (2008) Irina Giurgea et al. HUMAN MUTATION
- DLX5expression is monoallelic andDlx5is up-regulated in theMecp2-null frontal cortex
- (2008) Masaru Miyano et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The Reelin Signaling Pathway Promotes Dendritic Spine Development in Hippocampal Neurons
- (2008) S. Niu et al. JOURNAL OF NEUROSCIENCE
- CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates -Catenin Target Genes
- (2008) B. A. Thompson et al. MOLECULAR AND CELLULAR BIOLOGY
- Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
- (2008) Nicole C Allen et al. NATURE GENETICS
- Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
- (2008) Da Wei Huang et al. NUCLEIC ACIDS RESEARCH
- A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype
- (2008) Steven G. Potkin et al. SCHIZOPHRENIA BULLETIN
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