The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance

Telomerase Reverse Transcriptase Regulates microRNAs

(2015) Timo Lassmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantification of hTERT Splice Variants in Melanoma by SYBR Green Real-time Polymerase Chain Reaction Indicates a Negative Regulatory Role for the β Deletion Variant

(2015) Lisa F. Lincz et al.   NEOPLASIA

Silencing of TERT decreases levels of miR-1, miR-21, miR-29a and miR-208a in cardiomyocytes

(2014) T. I. Drevytska et al.   CELL BIOCHEMISTRY AND FUNCTION

Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress

(2014) G. Saretzki   CURRENT PHARMACEUTICAL DESIGN

Rif1 Maintains Telomere Length Homeostasis of ESCs by Mediating Heterochromatin Silencing

(2014) Jiameng Dan et al.   DEVELOPMENTAL CELL

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

(2014) Alec N. Sexton et al.   GENES & DEVELOPMENT

Telomerase Reverse Transcriptase Has an Extratelomeric Function in Somatic Cell Reprogramming

(2014) Taisuke Kinoshita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Telomerase Reverse Transcriptase in Heterochromatin Maintenance

(2014) Y. Maida et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomerase as a “stemness” enzyme

(2014) Feng Kong et al.   Science China-Life Sciences

Microenvironmental Regulation of Telomerase Isoforms in Human Embryonic Stem Cells

(2014) Lida Radan et al.   STEM CELLS AND DEVELOPMENT

Telomere and telomerase in chronic liver disease and hepatocarcinoma

(2014) Lucia Carulli   WORLD JOURNAL OF GASTROENTEROLOGY

Trend of telomerase activity change during human iPSC self-renewal and differentiation revealed by a quartz crystal microbalance based assay

(2014) Yitian Zhou et al.   Scientific Reports

Telomere Elongation and Naive Pluripotent Stem Cells Achieved from Telomerase Haplo-Insufficient Cells by Somatic Cell Nuclear Transfer

(2014) Li-Ying Sung et al.   Cell Reports

Telomere regulation in pluripotent stem cells

(2014) Yan Huang et al.   Protein & Cell

Telomere Length Reprogramming in Embryos and Stem Cells

(2014) Keri Kalmbach et al.   Biomed Research International

The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells

(2014) Yick W Fong et al.   eLife

SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells

(2014) Maria Luigia De Bonis et al.   Stem Cell Reports

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

Short Telomeres in ESCs Lead to Unstable Differentiation

(2013) Fabio Pucci et al.   Cell Stem Cell

Enhanced Telomere Rejuvenation in Pluripotent Cells Reprogrammed via Nuclear Transfer Relative to Induced Pluripotent Stem Cells

(2013) Rongrong Le et al.   Cell Stem Cell

Off-Target Effect of Endogenous siRNA Derived from RMRP in Human Cells

(2013) Yoshiko Maida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells

(2013) Sicong Zeng et al.   JOURNAL OF CELL SCIENCE

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs

(2013) Thomas Winkler et al.   JOURNAL OF CLINICAL INVESTIGATION

An Investigation of the Effects of the Core Protein Telomerase Reverse Transcriptase on Wnt Signaling in Breast Cancer Cells

(2013) I. Listerman et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species

(2013) S. Ozturk et al.   MOLECULAR HUMAN REPRODUCTION

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming

(2013) Xiaopeng Liu et al.   NATURE CELL BIOLOGY

ES Micro-Environment Enhances Stemness and Inhibits Apoptosis in Human Limbal Stem Cells via the Maintenance of Telomerase Activity

(2013) Zhiping Liu et al.   PLoS One

Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis

(2013) Chatchawan Singhapol et al.   PLoS One

Correction: Telomere Reprogramming and Maintenance in Porcine iPS Cells

(2013) Guangzhen Ji et al.   PLoS One

Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy

(2013) Mandy S. Wong et al.   Cell Reports

Abstract 2047: The interaction of ZSCAN4 with TRF1: Effects on regulation of telomere elongation in cancer cells

(2012) Kyungwoo Lee et al.   CANCER RESEARCH

Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation

(2012) Jing Jiang et al.   CELL RESEARCH

Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells

(2012) Nicola Festuccia et al.   Cell Stem Cell

Telomeres and Mitochondria in the Aging Heart

(2012) Javid Moslehi et al.   CIRCULATION RESEARCH

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer

(2012) Yong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation

(2012) J. Chung et al.   JOURNAL OF CELL SCIENCE

Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation

(2012) R. Hrdlickova et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells

(2012) Mangmang Li et al.   MOLECULAR CELL

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells

(2012) Z Liu et al.   ONCOGENE

Quantification of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase and Correlations with Telomerase Activity in Lung Cancer

(2012) Yan Liu et al.   PLoS One

Exclusion of Exon 2 Is a Common mRNA Splice Variant of Primate Telomerase Reverse Transcriptases

(2012) Johanna B. Withers et al.   PLoS One

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells

(2011) Fang Wang et al.   CELL RESEARCH

Association of telomere length with authentic pluripotency of ES/iPS cells

(2011) Junjiu Huang et al.   CELL RESEARCH

Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation

(2011) Marina Mattiussi et al.   CELLULAR SIGNALLING

Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives

(2011) Shiran Yehezkel et al.   Epigenetics

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Phenotypes in mTERT+/- and mTERT-/- Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase

(2011) M. A. Strong et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomerase and idiopathic pulmonary fibrosis

(2011) Mary Armanios   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Therapeutic opportunities: Telomere maintenance in inducible pluripotent stem cells

(2011) Francoise A. Gourronc et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Genetics of leukocyte telomere length and its role in atherosclerosis

(2011) Abraham Aviv   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

(2011) Luis F. Z. Batista et al.   NATURE

RMRP Is a Non-Coding RNA Essential for Early Murine Development

(2011) Joseph Rosenbluh et al.   PLoS One

Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells

(2011) E. Varela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Separation of telomerase functions by reverse genetics

(2011) S. Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance of tumor initiating cells of defined genetic composition by nucleostemin

(2011) N. Okamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction

(2010) Tal Biron-Shental et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells

(2010) I. R. Indran et al.   CANCER RESEARCH

Telomeres are shorter in placental trophoblasts of pregnancies complicated with intrauterine growth restriction (IUGR)

(2010) Tal Biron-Shental et al.   EARLY HUMAN DEVELOPMENT

TERC telomerase subunit gene copy number in placentas from pregnancies complicated with intrauterine growth restriction

(2010) Tal Biron-Shental et al.   EARLY HUMAN DEVELOPMENT

Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent

(2010) Nicole Büchner et al.   EXPERIMENTAL GERONTOLOGY

Robust activation of the human but not mouse telomerase gene during the induction of pluripotency

(2010) Renjith Mathew et al.   FASEB JOURNAL

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts

(2010) S. Turner et al.   MOLECULAR HUMAN REPRODUCTION

Zscan4 regulates telomere elongation and genomic stability in ES cells

(2010) Michal Zalzman et al.   NATURE

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

(2010) Suneet Agarwal et al.   NATURE

Chromatin regulation by Brg1 underlies heart muscle development and disease

(2010) Calvin T. Hang et al.   NATURE

Changes of Telomerase Activity by Alternative Splicing of Full-Length and β Variants of hTERT in Breast Cancer Patients

(2010) Sun Young Rha et al.   ONCOLOGY RESEARCH

Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming

(2010) H Vaziri et al.   Regenerative Medicine

Krüppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells

(2010) Chui-Wei Wong et al.   STEM CELLS

Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair

(2010) Tao-Sheng Li et al.   STEM CELLS

Telomerase Reverse Transcriptase Related with Telomerase Activity Regulates Tumorigenic Potential of Mouse Embryonic Stem Cells

(2010) Ki Dae Park et al.   STEM CELLS AND DEVELOPMENT

Effects of Long-Term Culture on Human Embryonic Stem Cell Aging

(2010) Xiaoyan Xie et al.   STEM CELLS AND DEVELOPMENT

Telomerase: An RNP Enzyme Synthesizes DNA

(2010) E. H. Blackburn et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

(2009) Judith Haendeler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells

(2009) Na Xu et al.   CELL

Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells

(2009) Yong Zhao et al.   CELL

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors

(2009) Pamela Nicholson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells

(2009) L. H. Wong et al.   GENOME RESEARCH

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

(2009) Yoshiko Maida et al.   NATURE

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb

(2009) Bo Feng et al.   NATURE CELL BIOLOGY

Telomere Dynamics in Human Cells Reprogrammed to Pluripotency

(2009) Steven T. Suhr et al.   PLoS One

Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

(2009) Catherine E Forristal et al.   REPRODUCTION

Novel STAT3 Target Genes Exert Distinct Roles in the Inhibition of Mesoderm and Endoderm Differentiation in Cooperation with Nanog

(2009) Pierre-Yves Bourillot et al.   STEM CELLS

Actions of human telomerase beyond telomeres

(2008) Yusheng Cong et al.   CELL RESEARCH

Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse

(2008) Matthias Stadtfeld et al.   Cell Stem Cell

c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts

(2008) Marius Wernig et al.   Cell Stem Cell

Nuclear Protein Tyrosine Phosphatase Shp-2 Is One Important Negative Regulator of Nuclear Export of Telomerase Reverse Transcriptase

(2008) Sascha Jakob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

(2008) Jinkuk Choi et al.   PLoS Genetics

A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice

(2008) B.-W. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Key Role for Telomerase Reverse Transcriptase Unit in Modulating Human Embryonic Stem Cell Proliferation, Cell Cycle Dynamics, and In Vitro Differentiation

(2008) Chunbo Yang et al.   STEM CELLS

The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development

(2007) C. T. Griffin et al.   DEVELOPMENT