DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

(2016) W. G. Land et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The role of danger signals and ectonucleotidases in acute graft-versus-host disease

(2016) Petya Apostolova et al.   HUMAN IMMUNOLOGY

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

The T helper type 17/regulatory T cell paradigm in pregnancy

(2016) Ana Sofia Figueiredo et al.   IMMUNOLOGY

Nonapoptotic cell death in acute kidney injury and transplantation

(2016) Andreas Linkermann   KIDNEY INTERNATIONAL

Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

(2016) Abhishek D. Garg et al.   Science Translational Medicine

Extracellular ATP and P2X7 receptor exert context-specific immunogenic effects after immunogenic cancer cell death

(2016) A D Garg et al.   Cell Death & Disease

Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy

(2015) Jean-Paul Decuypere et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

(2015) Nobuhiko Hiramatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Purinergic signaling in the immune system

(2015) Francesco Di Virgilio et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

(2015) Zhixia Zhou et al.   CANCER LETTERS

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin

(2015) A. M. Dudek-Peri  et al.   CANCER RESEARCH

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting Pathogenic Postischemic Self-Recognition by Natural IgM to Protect Against Posttransplantation Cardiac Reperfusion InjuryCLINICAL PERSPECTIVE

(2015) Carl Atkinson et al.   CIRCULATION

ER Stress and Autophagy

(2015) W. Lee et al.   CURRENT MOLECULAR MEDICINE

Effects of complement activation on allograft injury

(2015) Joong Hyuk Sheen et al.   Current Opinion in Organ Transplantation

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Immunogenic cell death

(2015) Abhishek D. Garg et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis

(2015) Jo Marie Tran Janco et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer

(2015) Hiroshi Katoh et al.   MEDIATORS OF INFLAMMATION

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

(2015) Tien-Jen Lin et al.   Molecular Cancer

Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91

(2015) Maria Saveria Gilardini Montani et al.   NUTRITION

Hyperthermic intraperitoneal chemotherapy leads to an anticancer immune response via exposure of cell surface heat shock protein 90

(2015) B Zunino et al.   ONCOGENE

eIF2α phosphorylation as a biomarker of immunogenic cell death

(2015) Oliver Kepp et al.   SEMINARS IN CANCER BIOLOGY

The PERKs of damage-associated molecular patterns mediating cancer immunogenicity: From sensor to the plasma membrane and beyond

(2015) A.R. van Vliet et al.   SEMINARS IN CANCER BIOLOGY

CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection

(2015) Osamu Yoshida et al.   TRANSPLANT IMMUNOLOGY

Intermedin protects against renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress

(2015) Yanhong Wang et al.   BMC Nephrology

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

(2015) Abhishek D. Garg et al.   Oncotarget

Calreticulin Binds to Fas Ligand and Inhibits Neuronal Cell Apoptosis Induced by Ischemia-Reperfusion Injury

(2015) Beilei Chen et al.   Biomed Research International

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

(2015) Jitka Fucikova et al.   Frontiers in Immunology

The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome

(2015) Sara Omenetti et al.   Frontiers in Immunology

Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity

(2015) Valerie R. Wiersma et al.   Frontiers in Oncology

Immunogenic cell death inducers as anticancer agents

(2015) Oliver Kepp et al.   Oncotarget

Novel method for real-time monitoring of ATP release reveals multiple phases of autocrine purinergic signalling during immune cell activation

(2014) C. Ledderose et al.   Acta Physiologica

The Purinergic System in Allotransplantation

(2014) A. Vergani et al.   AMERICAN JOURNAL OF TRANSPLANTATION

HMGB1 Is Involved in Chronic Rejection of Cardiac Allograft via Promoting Inflammatory-Like mDCs

(2014) H. Zou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Dendritic Cell Cross Talk with Innate and Innate-like Effector Cells in Antitumor Immunity: Implications for DC Vaccination

(2014) Jasper J. P. van Beek et al.   CRITICAL REVIEWS IN IMMUNOLOGY

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Induced regulatory T cells in inhibitory microenvironments created by cancer

(2014) Theresa L Whiteside   EXPERT OPINION ON BIOLOGICAL THERAPY

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Shaping the repertoire of tumor-infiltrating effector and regulatory T cells

(2014) Peter A. Savage et al.   IMMUNOLOGICAL REVIEWS

Newcastle disease virotherapy induces long-term survival and tumor-specific immune memory in orthotopic glioma through the induction of immunogenic cell death

(2014) Carolien A. Koks et al.   INTERNATIONAL JOURNAL OF CANCER

STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells

(2014) Jared Klarquist et al.   JOURNAL OF IMMUNOLOGY

High-mobility group box-1 in sterile inflammation

(2014) A. Tsung et al.   JOURNAL OF INTERNAL MEDICINE

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses

(2014) Abhishek D. Garg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Atorvastatin Post-Conditioning Attenuates Myocardial Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress–Related Apoptosis

(2014) Jing-gang Xia et al.   SHOCK

High-mobility group box 1 accelerates early acute allograft rejection via enhancing IL-17+γδ T-cell response

(2014) Quansong Xia et al.   TRANSPLANT INTERNATIONAL

Danger signals – damaged-self recognition across the tree of life

(2014) Martin Heil et al.   Frontiers in Plant Science

Regulatory T-Cells in Pregnancy: Historical Perspective, State of the Art, and Burning Questions

(2014) Maria Grazia Ruocco et al.   Frontiers in Immunology

STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression

(2014) Nina Le Bert et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Complement Mediated Renal Inflammation Induced by Donor Brain Death: Role of Renal C5a-C5aR Interaction

(2013) M. B. van Werkhoven et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

Cell-Death-Associated Molecular Patterns As Determinants of Cancer Immunogenicity

(2013) Sylvain Ladoire et al.   ANTIOXIDANTS & REDOX SIGNALING

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

(2013) Yidan Wang et al.   Autophagy

Cancer immunogenicity, danger signals, and DAMPs: What, when, and how?

(2013) Abhishek D. Garg et al.   BIOFACTORS

Danger signalling during cancer cell death: origins, plasticity and regulation

(2013) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of rejection

(2013) Conrad A. Farrar et al.   Current Opinion in Organ Transplantation

Crosstalk between ER stress and immunogenic cell death

(2013) Oliver Kepp et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection

(2013) A. Vergani et al.   DIABETES

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

(2013) Laurence Zitvogel et al.   IMMUNITY

Secreted Heat Shock Protein 90α (HSP90α) Induces Nuclear Factor-κB-mediated TCF12 Protein Expression to Down-regulate E-cadherin and to Enhance Colorectal Cancer Cell Migration and Invasion

(2013) Wei-Shone Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

(2013) Ilkka Liikanen et al.   MOLECULAR THERAPY

Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer Immunity

(2013) Aleksandra M. Dudek et al.   Frontiers in Immunology

ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

(2013) Yuting Ma et al.   OncoImmunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death

(2012) Isabelle Martins et al.   Autophagy

Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7

(2012) Andrea Vergani et al.   CIRCULATION

Clinical Analysis of Perioperative Complement Activity during Ischemia/Reperfusion Injury following Renal Transplantation

(2012) W. Blogowski et al.   Clinical Journal of the American Society of Nephrology

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

C3a and C5a Promote Renal Ischemia-Reperfusion Injury

(2012) Q. Peng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91

(2012) Mara Cirone et al.   PLoS One

ATP Release from Dying Autophagic Cells and Their Phagocytosis Are Crucial for Inflammasome Activation in Macrophages

(2012) Gizem Ayna et al.   PLoS One

IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation

(2012) I B Mosbah et al.   Cell Death & Disease

Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

(2012) Mickaël Michaud et al.   OncoImmunology

The emergence of phox-ER stress induced immunogenic apoptosis

(2012) Abhishek D. Garg et al.   OncoImmunology

HMGB1 as an autophagy sensor in oxidative stress

(2011) Rui Kang et al.   Autophagy

Calreticulin as a potential diagnostic biomarker for lung cancer

(2011) Rongrong Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

(2011) S. R. Mattarollo et al.   CANCER RESEARCH

The new face of anaphylatoxins in immune regulation

(2011) Wuding Zhou   IMMUNOBIOLOGY

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

(2011) Yuting Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Systemic Complement Activation in Deceased Donors Is Associated With Acute Rejection After Renal Transplantation in the Recipient

(2011) Jeffrey Damman et al.   TRANSPLANTATION

Type I Interferon Pathway Mediates Renal Ischemia/Reperfusion Injury

(2011) Maria Cecilia S. Freitas et al.   TRANSPLANTATION

Emerging role of innate immunity in organ transplantation Part II: potential of damage-associated molecular patterns to generate immunostimulatory dendritic cells

(2011) Walter G. Land   Transplantation Reviews

Natural Killer Cells and the Immune Response in Solid Organ Transplantation

(2010) W. Van Der Touw et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ex vivo- and in vivo-induced dead tumor cells as modulators of antitumor responses

(2010) Eva-Maria Weiss et al.   Annals of the New York Academy of Sciences

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases

(2010) Dmitri V. Krysko et al.   APOPTOSIS

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

(2010) Abhishek D. Garg et al.   APOPTOSIS

Extracellular heat shock protein HSP90β secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-β1

(2010) Shigeki Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death

(2010) R. Zappasodi et al.   CANCER RESEARCH

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Natural killer cells in rejection and tolerance of solid organ allografts

(2010) Gilles Benichou et al.   Current Opinion in Organ Transplantation

Secreted Heat Shock Protein 90α Induces Colorectal Cancer Cell Invasion through CD91/LRP-1 and NF-κB-mediated Integrin αVExpression

(2010) Jinn-Shiun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response

(2010) Lihua Duan et al.   LABORATORY INVESTIGATION

Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts

(2010) Christopher D. Anderson et al.   LIVER TRANSPLANTATION

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

(2010) M. P. Chao et al.   Science Translational Medicine

Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia

(2010) M Wemeau et al.   Cell Death & Disease

Potential Role of NKG2D and Its Ligands in Organ Transplantation: New Target for Immunointervention

(2009) B. Suárez-Álvarez et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

The Effect of High Mobility Group Box-1 Protein on Splenic Dendritic Cell Maturation in Rats

(2009) Xiao-mei Zhu et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Effects of Humoral Immunity and Calreticulin Overexpression on Postoperative Course in Breast Cancer

(2009) Aleksandra Erić et al.   PATHOLOGY & ONCOLOGY RESEARCH

Extracellular ATP in the Immune System: More Than Just a "Danger Signal"

(2009) A. Trautmann   Science Signaling

Identification of Epitopes and Immunodominant Regions on the MICA Protein Defined by Alloantibodies From Kidney Transplant Patients

(2009) Beatriz Suárez-Álvarez et al.   TRANSPLANTATION

Expression of NKG2D and Its Ligand in Mouse Heart Allografts May Have a Role in Acute Rejection

(2009) L. Feng et al.   TRANSPLANTATION PROCEEDINGS

Identification of Calreticulin as a Prognosis Marker and Angiogenic Regulator in Human Gastric Cancer

(2008) Chiung-Nien Chen et al.   ANNALS OF SURGICAL ONCOLOGY

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

(2008) J Thorburn et al.   CELL DEATH AND DIFFERENTIATION

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

(2008) T Panaretakis et al.   CELL DEATH AND DIFFERENTIATION

Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression

(2008) P. Verginis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA