A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

(2017) Katharine A. White et al.   JOURNAL OF CELL SCIENCE

Functional tuning of the catalytic residue pK a in a de novo designed esterase

(2017) Katharina Hiebler et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

(2016) M. L. Lozano et al.   BLOOD

Lost GRP on cytotoxicity?

(2016) Jeroen P Roose   NATURE IMMUNOLOGY

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

(2016) Elisabeth Salzer et al.   NATURE IMMUNOLOGY

One-way membrane trafficking of SOS in receptor-triggered Ras activation

(2016) Sune M Christensen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

One-way membrane trafficking of SOS in receptor-triggered Ras activation

(2016) Sune M Christensen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

DelPhiPKa web server: predicting pKaof proteins, RNAs and DNAs

(2015) Lin Wang et al.   BIOINFORMATICS

RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth

(2015) Philippe Depeille et al.   NATURE CELL BIOLOGY

RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines

(2015) O Ksionda et al.   ONCOGENE

Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

(2015) Bree K Grillo-Hill et al.   eLife

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

(2014) Matthias Canault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Function of RasGRP3 in the formation and progression of human breast cancer

(2014) Zsuzsanna Nagy et al.   Molecular Cancer

Considering Protonation as a Posttranslational Modification Regulating Protein Structure and Function

(2013) André Schönichen et al.   Annual Review of Biophysics

Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate

(2013) Greg M. Findlay et al.   CELL

pH sensing by FAK-His58 regulates focal adhesion remodeling

(2013) Chang-Hoon Choi et al.   JOURNAL OF CELL BIOLOGY

Selectivity of CDC25 Homology Domain-Containing Guanine Nucleotide Exchange Factors

(2013) Milica Popovic et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

(2013) C. Hartzell et al.   Science Signaling

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

(2013) Jeffrey S Iwig et al.   eLife

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

(2013) Stephen R Daley et al.   eLife

Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells

(2013) Jesse E. Jun et al.   Frontiers in Immunology

The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

(2012) Ana Maria Rojas et al.   JOURNAL OF CELL BIOLOGY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

(2011) Alfred Wittinghofer et al.   Annual Review of Biochemistry

Phosphoinositide 3-Kinase Regulates Plasma Membrane Targeting of the Ras-specific Exchange Factor RasGRP1

(2011) Bari Zahedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma

(2011) D Yang et al.   ONCOGENE

Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases

(2011) Vincent Plagnol et al.   PLoS Genetics

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

RasGRP3 Contributes to Formation and Maintenance of the Prostate Cancer Phenotype

(2010) D. Yang et al.   CANCER RESEARCH

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Cytosolic Ca2+ Buffers

(2010) B. Schwaller   Cold Spring Harbor Perspectives in Biology

RasGRP1 Transgenic Mice Develop Cutaneous Squamous Cell Carcinomas in Response to Skin Wounding

(2009) Federico R. Diez et al.   AMERICAN JOURNAL OF PATHOLOGY

Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies

(2009) H Q Qu et al.   JOURNAL OF MEDICAL GENETICS

Electrostatic Effects in a Network of Polar and Ionizable Groups in Staphylococcal Nuclease

(2008) Kelli L. Baran et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

(2008) Holger Rehmann et al.   NATURE

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling

(2008) J. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA