Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

Key role of integrin αIIbβ3 signaling to Syk kinase in tissue factor-induced thrombin generation

(2012) Paola E. J. van der Meijden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rho GTPases in platelet function

(2012) J. E. ASLAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rap1-Rac1 Circuits Potentiate Platelet Activation

(2011) Lucia Stefanini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CalDAG-GEFI deficiency protects mice in a novel model of Fc RIIA-mediated thrombosis and thrombocytopenia

(2011) M. Stolla et al.   BLOOD

Hematologically important mutations: Leukocyte adhesion deficiency (first update)

(2011) Edith van de Vijver et al.   BLOOD CELLS MOLECULES AND DISEASES

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling

(2011) Anika Stadtmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin αIIbβ3Outside-in Signaling

(2011) Guoying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin- and Nonintegrin-Related Defects in Different Steps of Leukocyte Adhesion

(2011) P. Robert et al.   JOURNAL OF IMMUNOLOGY

Advances in our understanding of the molecular basis of disorders of platelet function

(2011) A. NURDEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The kinetics of  IIb 3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy

(2010) M. Stolla et al.   BLOOD

Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

(2010) A. McDowall et al.   BLOOD

Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis

(2010) C. Carbo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3

(2010) Kerstin Jurk et al.   THROMBOSIS AND HAEMOSTASIS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

(2009) L. Stefanini et al.   BLOOD

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

LAD-1/variant syndrome is caused by mutations inFERMT3

(2008) Taco W. Kuijpers et al.   BLOOD

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin  IIb 3 in platelets

(2008) S. M. Cifuni et al.   BLOOD

Specificity in Ras and Rap Signaling

(2008) Judith H. Raaijmakers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY