Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells

(2016) Schammim Ray Amith et al.   BIOCHEMICAL PHARMACOLOGY

Na + /H + antiporter (NHE1) and lactate/H + symporters (MCTs) in pH homeostasis and cancer metabolism

(2016) Laurent Counillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth

(2016) Alan McIntyre et al.   CANCER RESEARCH

Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation

(2016) Bryne Ulmschneider et al.   JOURNAL OF CELL BIOLOGY

Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment

(2016) Anne Poder Andersen et al.   Molecular Cancer

Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid

(2016) Alzbeta Hulikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells

(2016) Schammim Ray Amith et al.   Oncotarget

Use of Proton Pump Inhibitors as Adjunct Treatment for Triple-Negative Breast Cancers. An Introductory Study

(2016) Wayne Goh et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Role of ion channels in ionizing radiation-induced cell death

(2015) Stephan M. Huber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ion channels and transporters in metastasis

(2015) Christian Stock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

(2015) Khalid O Alfarouk et al.   Cancer Cell International

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors

(2015) F. A. Gallagher et al.   CANCER RESEARCH

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

The Na+/HCO3−Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

(2015) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis

(2015) Gordon T Brown et al.   JOURNAL OF PATHOLOGY

Extracellular regulation of metalloproteinases

(2015) Kazuhiro Yamamoto et al.   MATRIX BIOLOGY

ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH

(2015) Guopei Zheng et al.   Molecular Cancer

Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations

(2015) Bradley A. Webb et al.   NATURE

Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan

(2015) Kavindra Nath et al.   NMR IN BIOMEDICINE

Disrupting Na+,HCO3–-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development

(2015) S Lee et al.   ONCOGENE

Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

(2015) Joanna Kopecka et al.   Oncotarget

Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

(2015) Bree K Grillo-Hill et al.   eLife

A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy

(2015) Rosa Angela Cardone et al.   NEOPLASIA

The Na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells

(2015) Schammim Ray Amith et al.   Oncotarget

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

(2015) Chaim B Colen et al.   NEOPLASIA

Role of NHE1 in the Cellular Dysfunction of Acute Metabolic Acidosis

(2014) Dongmei Wu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+extrusion, cell migration and survival

(2014) Damin Cong et al.   CARCINOGENESIS

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis

(2014) Brian T. Beaty et al.   JOURNAL OF CELL BIOLOGY

Role of pHi, and proton transporters in oncogene-driven neoplastic transformation

(2014) S. J. Reshkin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

(2014) A. P. Andersen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulation and roles of bicarbonate transporters in cancer

(2014) Andrej Gorbatenko et al.   Frontiers in Physiology

Considering Protonation as a Posttranslational Modification Regulating Protein Structure and Function

(2013) André Schönichen et al.   Annual Review of Biophysics

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer

(2013) Chloë Daniel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

Ion Channels and Transporters in Cancer: Pathophysiology, Regulation, and Clinical Potential

(2013) S. F. Pedersen et al.   CANCER RESEARCH

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium

(2013) A. G. Petzoldt et al.   Disease Models & Mechanisms

pH sensing by FAK-His58 regulates focal adhesion remodeling

(2013) Chang-Hoon Choi et al.   JOURNAL OF CELL BIOLOGY

Protons as Second Messenger Regulators of G Protein Signaling

(2013) Daniel G. Isom et al.   MOLECULAR CELL

Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration

(2013) C J De Saedeleer et al.   ONCOGENE

Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe

(2013) MARIA RAFFAELLA GRECO et al.   ONCOLOGY REPORTS

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

Contribution of Na+,HCO3−-cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7)

(2012) Ebbe Boedtkjer et al.   INTERNATIONAL JOURNAL OF CANCER

PDGFR  signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways

(2012) D. L. Clement et al.   JOURNAL OF CELL SCIENCE

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

The Na+/H+ exchanger NHE1, but not the Na+, cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

(2011) Gitte Lauritzen et al.   CANCER LETTERS

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP

(2011) Yani Lin et al.   CELL BIOCHEMISTRY AND FUNCTION

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: Key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH

(2011) Johanna Chiche et al.   INTERNATIONAL JOURNAL OF CANCER

Phosphofructokinase type 1 kinetics, isoform expression and gene polymorphisms in cancer cells

(2011) Rafael Moreno-Sánchez et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Imaging pH and metastasis

(2011) Arig Ibrahim Hashim et al.   NMR IN BIOMEDICINE

The Spatial Organization of Proton and Lactate Transport in a Rat Brain Tumor

(2011) Emmanuelle Grillon et al.   PLoS One

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Na+/H+ exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility

(2010) Xuekang Yang et al.   CANCER LETTERS

Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase

(2010) Reinhard Dechant et al.   EMBO JOURNAL

NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance

(2010) G. Lauritzen et al.   EXPERIMENTAL CELL RESEARCH

Expression of Actin-interacting Protein 1 Suppresses Impaired Chemotaxis of Dictyostelium Cells Lacking the Na+-H+ Exchanger NHE1

(2010) Chang-Hoon Choi et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sodium-Hydrogen Exchanger NHE1 Is an Akt Substrate Necessary for Actin Filament Reorganization by Growth Factors

(2009) Marcel E. Meima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protons make tumor cells move like clockwork

(2009) Christian Stock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Kinetic Analysis of the Regulation of the Na+/H+Exchanger NHE-1 by Osmotic Shocks†

(2008) Jérôme Lacroix et al.   BIOCHEMISTRY

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

(2008) Christian Frantz et al.   JOURNAL OF CELL BIOLOGY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling

(2008) J. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA