Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

T-cell subsets in the germinal center

(2013) Roybel R. Ramiscal et al.   IMMUNOLOGICAL REVIEWS

RasGRP1, but Not RasGRP3, Is Required for Efficient Thymic β-Selection and ERK Activation Downstream of CXCR4

(2013) Dominic P. Golec et al.   PLoS One

Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells

(2013) Robert L. Kortum et al.   TRENDS IN IMMUNOLOGY

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

(2013) Jeffrey S Iwig et al.   eLife

The Role of Ras Guanine Nucleotide Releasing Protein 4 in FcϵRI-mediated Signaling, Mast Cell Function, and T Cell Development

(2012) Minghua Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain

(2012) Deirdre M. Fuller et al.   PLoS One

Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells

(2012) J. N. Mandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models

(2012) T. D. Andrews et al.   Open Biology

Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner

(2011) J. Wang et al.   BLOOD

Negative regulation of mTOR activation by diacylglycerol kinases

(2011) B. K. Gorentla et al.   BLOOD

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

(2011) D. G. Silva et al.   DIABETES

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

(2011) Mehmet Yabas et al.   NATURE IMMUNOLOGY

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Basal LAT-diacylglycerol-RasGRP1 Signals in T Cells Maintain TCRα Gene Expression

(2011) Evan Markegard et al.   PLoS One

Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases

(2011) Vincent Plagnol et al.   PLoS Genetics

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

(2010) S. Zhang et al.   BLOOD

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1

(2010) W. Pan et al.   JOURNAL OF IMMUNOLOGY

Insights into the domain and repeat architecture of target of rapamycin

(2010) Bruce A. Knutson   JOURNAL OF STRUCTURAL BIOLOGY

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

The Use of Carboxyfluorescein Diacetate Succinimidyl Ester (CFSE) to Monitor Lymphocyte Proliferation

(2010) Benjamin J. C. Quah et al.   Jove-Journal of Visualized Experiments

Functional links between diacylglycerol and phosphatidylinositol signaling systems in human leukocyte-derived cell lines

(2009) Ho Y. Poon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane localization of RasGRP1 is controlled by an EF-hand, and by the GEF domain

(2009) Ghazaleh Tazmini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells

(2009) R. J. Salmond et al.   JOURNAL OF IMMUNOLOGY

Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies

(2009) H Q Qu et al.   JOURNAL OF MEDICAL GENETICS

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

(2009) Katrina L Randall et al.   NATURE IMMUNOLOGY

K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to  -secretase inhibitors

(2008) T. Kindler et al.   BLOOD

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation

(2008) J. Zhang et al.   BLOOD