New Frontiers in Genetics, Gut Microbiota, and Immunity: A Rosetta Stone for the Pathogenesis of Inflammatory Bowel Disease

Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice

(2017) Han-Byul Kim et al.   GASTROENTEROLOGY

Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

CD28 is a critical target for PD-1 blockade

(2017) Priscilla N. Kelly   SCIENCE

Genetics and Pathogenesis of Inflammatory Bowel Disease

(2016) Ta-Chiang Liu et al.   Annual Review of Pathology-Mechanisms of Disease

Intimate gut interactions: helminths and the microbiota

(2016) Nicola L Harris   CELL RESEARCH

Lymphocyte Antigen 75 Polymorphisms Are Associated with Disease Susceptibility and Phenotype in Japanese Patients with Inflammatory Bowel Disease

(2016) Atsuhiro Hirayama et al.   DISEASE MARKERS

Commensal-Specific CD4+ Cells From Patients With Crohn’s Disease Have a T-Helper 17 Inflammatory Profile

(2016) Elisabeth Calderón-Gómez et al.   GASTROENTEROLOGY

Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes

(2016) Yin Cao et al.   GASTROENTEROLOGY

The Changing Landscape of Inflammatory Bowel Disease: East Meets West

(2016) Gilaad G. Kaplan et al.   GASTROENTEROLOGY

Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease

(2016) Hironobu Fujii et al.   GASTROENTEROLOGY

Fungal microbiota dysbiosis in IBD

(2016) Harry Sokol et al.   GUT

Viral Safeguard: The Enteric Virome Protects against Gut Inflammation

(2016) Stephanie M. Karst   IMMUNITY

Gut Microbial Diversity Is Reduced in Smokers with Crohnʼs Disease

(2016) Jorrit L. Opstelten et al.   INFLAMMATORY BOWEL DISEASES

GLP-1 Induces Barrier Protective Expression in Brunnerʼs Glands and Regulates Colonic Inflammation

(2016) Claus H. Bang-Berthelsen et al.   INFLAMMATORY BOWEL DISEASES

Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells

(2016) Christian H. Gabriel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Dysbiosis in fungal microbiota in IBD

(2016) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

The emerging landscape of circular RNA in life processes

(2016) Shibin Qu et al.   RNA Biology

Clinical course of Crohn’s disease during the first 5 years. Results from a population-based cohort in Sweden (ICURE) diagnosed 2005–2009

(2016) Anders Rönnblom et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Transkingdom control of viral infection and immunity in the mammalian intestine

(2016) J. K. Pfeiffer et al.   SCIENCE

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

Helminths and Intestinal Flora Team Up to Improve Gut Health

(2016) Paul Giacomin et al.   TRENDS IN PARASITOLOGY

Chinese physicians’ perceptions of fecal microbiota transplantation

(2016) Rong-Rong Ren et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Plasma long noncoding RNA expression profile identified by microarray in patients with Crohn’s disease

(2016) Dong Chen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Environmental risk factors for inflammatory bowel diseases: Evidence based literature review

(2016) Ayokunle T Abegunde et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

(2016) Julio Gomez-Rodriguez et al.   Nature Communications

Deviations in human gut microbiota: a novel diagnostic test for determining dysbiosis in patients with IBS or IBD

(2015) C. Casén et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Epithelial Danger Signal IL-1α Is a Potent Activator of Fibroblasts and Reactivator of Intestinal Inflammation

(2015) Melania Scarpa et al.   AMERICAN JOURNAL OF PATHOLOGY

Erratum to: A de novo whole gene deletion of XIAP detected by exome sequencing analysis in very early onset inflammatory bowel disease: a case report

(2015) Judith R. Kelsen et al.   BMC GASTROENTEROLOGY

MicroRNA signatures differentiate Crohn’s disease from ulcerative colitis

(2015) Jeremy S Schaefer et al.   BMC IMMUNOLOGY

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Differential expression of key regulators of Toll-like receptors in ulcerative colitis and Crohn's disease: a role for Tollip and peroxisome proliferator-activated receptor gamma?

(2015) P. Fernandes et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The small bowel microbiota

(2015) Carthage Moran et al.   CURRENT OPINION IN GASTROENTEROLOGY

The Enteric Virome in Inflammatory Bowel Disease

(2015) Johanne Brooks et al.   GASTROENTEROLOGY

Exome Sequencing Analysis Reveals Variants in Primary Immunodeficiency Genes in Patients With Very Early Onset Inflammatory Bowel Disease

(2015) Judith R. Kelsen et al.   GASTROENTEROLOGY

Identification of Risk Loci for Crohn’s Disease Phenotypes Using a Genome-Wide Association Study

(2015) Arnald Alonso et al.   GASTROENTEROLOGY

Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial

(2015) Paul Moayyedi et al.   GASTROENTEROLOGY

Genetics of Inflammatory Bowel Diseases

(2015) Dermot P.B. McGovern et al.   GASTROENTEROLOGY

Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants

(2015) Sung Noh Hong et al.   GUT

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

(2015) Mario M. Zaiss et al.   IMMUNITY

A Genomic Virulence Reference Map of Enterococcus faecalis Reveals an Important Contribution of Phage03-Like Elements in Nosocomial Genetic Lineages to Pathogenicity in a Caenorhabditis elegans Infection Model

(2015) Sabina Leanti La Rosa et al.   INFECTION AND IMMUNITY

Combinatorial Effects of Diet and Genetics on Inflammatory Bowel Disease Pathogenesis

(2015) Laura J. Dixon et al.   INFLAMMATORY BOWEL DISEASES

Oxidative Stress and DNA Damage

(2015) Cristiana Pereira et al.   INFLAMMATORY BOWEL DISEASES

Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status

(2015) Johannes Stallhofer et al.   INFLAMMATORY BOWEL DISEASES

Metagenomic Analysis of Crohnʼs Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers

(2015) Vicente Pérez-Brocal et al.   INFLAMMATORY BOWEL DISEASES

Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease

(2015) Christel Chehoud et al.   INFLAMMATORY BOWEL DISEASES

Reduced Dendritic Cells Expressing CD200R1 in Children with Inflammatory Bowel Disease: Correlation with Th17 and Regulatory T Cells

(2015) Mohamed Elshal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galectin-1 Regulates Tissue Exit of Specific Dendritic Cell Populations

(2015) Sandra Thiemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fecal Microbiota Transplantation for Recurrent C. difficile Infection in a Patient with Chronic Refractory Ulcerative Colitis

(2015) A. Aratari et al.   Journal of Crohns & Colitis

Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn’s Disease Patients

(2015) Giuseppina Liguori et al.   Journal of Crohns & Colitis

Clinical Features of Interleukin 10 Receptor Gene Mutations in Children With Very Early–Onset Inflammatory Bowel Disease

(2015) Omer F. Beser et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis

(2015) Bota Cui et al.   Journal of Translational Medicine

Drugging the gut microbiome

(2015) Ken Garber   NATURE BIOTECHNOLOGY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Gastroenterologist perceptions of faecal microbiota transplantation

(2015) Sudarshan Paramsothy   WORLD JOURNAL OF GASTROENTEROLOGY

Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury

(2015) Dawei Chen et al.   Scientific Reports

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

(2015) Shuiqing Hu et al.   Cell Reports

Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis

(2015) Italia Loddo et al.   Frontiers in Immunology

Genetic studies of Crohn's disease: Past, present and future

(2014) Jimmy Z. Liu et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease

(2014) P.J. Basso et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

What Lies Within: Coinfections and Immunity

(2014) Blossom Damania et al.   Cell Host & Microbe

The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases – Lessons learned from experimental models

(2014) Mònica Aguilera et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tu1164 Environmental Risk Factors in Inflammatory Bowel Disease in Asia-Pacific: A Population-Based Case-Control Study

(2014) Siew C. Ng et al.   GASTROENTEROLOGY

Activation of Pattern Recognition Receptors Up-Regulates Metallothioneins, Thereby Increasing Intracellular Accumulation of Zinc, Autophagy, and Bacterial Clearance by Macrophages

(2014) Amit Lahiri et al.   GASTROENTEROLOGY

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease

(2014) Holm H. Uhlig et al.   GASTROENTEROLOGY

Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings

(2014) Charlotte R Hedin et al.   GUT

MicroRNAs: new players in IBD

(2014) R Kalla et al.   GUT

Early-onset Crohn’s disease and autoimmunity associated with a variant in CTLA-4

(2014) Sebastian Zeissig et al.   GUT

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

(2014) Deepshika Ramanan et al.   IMMUNITY

Metabolic Alterations to the Mucosal Microbiota in Inflammatory Bowel Disease

(2014) Michael Davenport et al.   INFLAMMATORY BOWEL DISEASES

Overexpression of ATP-activated P2X7 Receptors in the Intestinal Mucosa Is Implicated in the Pathogenesis of Crohnʼs Disease

(2014) Adriane R. Neves et al.   INFLAMMATORY BOWEL DISEASES

Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes

(2014) Mireia Lopez-Siles et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Rectal microRNAs are perturbed in pediatric inflammatory bowel disease of the colon

(2014) Adam M. Zahm et al.   Journal of Crohns & Colitis

The multilayered complexity of ceRNA crosstalk and competition

(2014) Yvonne Tay et al.   NATURE

Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation

(2014) Zhonghan Li et al.   RNA Biology

Clinical characteristics and treatment of inflammatory bowel disease: A comparison of Eastern and Western perspectives

(2014) Soo Jung Park   WORLD JOURNAL OF GASTROENTEROLOGY

Immunopathology of inflammatory bowel disease

(2014) Kori L Wallace   WORLD JOURNAL OF GASTROENTEROLOGY

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Evolution of Invasion in a Diverse Set of Fusobacterium Species

(2014) Abigail Manson McGuire et al.   mBio

Bacteriophages: an underestimated role in human and animal health?

(2014) Marianne De Paepe et al.   Frontiers in Cellular and Infection Microbiology

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges

(2013) A. P. Hutchins et al.   Briefings in Functional Genomics

Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study

(2013) Siew C. Ng et al.   GASTROENTEROLOGY

MicroRNA-124 Regulates STAT3 Expression and Is Down-regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis

(2013) Georgios Koukos et al.   GASTROENTEROLOGY

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations

(2013) Suk-Kyun Yang et al.   GUT

Genetic Susceptibility in IBD

(2013) James D. Doecke et al.   INFLAMMATORY BOWEL DISEASES

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

(2013) Matthew R. Hepworth et al.   NATURE

Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease

(2013) C. G. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteriophage adhering to mucus provide a non-host-derived immunity

(2013) J. J. Barr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis

(2012) Richard Hansen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure

(2012) Thomas Maslanik et al.   BRAIN BEHAVIOR AND IMMUNITY

A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohn's Disease in a Japanese Population

(2012) Keiko Yamazaki et al.   GASTROENTEROLOGY

CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome

(2012) A. Stern et al.   GENOME RESEARCH

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Mendelian traits causing susceptibility to mucocutaneous fungal infections in human subjects

(2012) Karin R. Engelhardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

The gut microbiota in IBD

(2012) Chaysavanh Manichanh et al.   Nature Reviews Gastroenterology & Hepatology

Integrated Metagenomics/Metaproteomics Reveals Human Host-Microbiota Signatures of Crohn's Disease

(2012) Alison R. Erickson et al.   PLoS One

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

The functional −374T/A polymorphism of the receptor for advanced glycation end products may modulate Crohn's disease

(2011) Jan Däbritz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

(2011) Alan W Walker et al.   BMC MICROBIOLOGY

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant inNCF2that results in reduced binding to RAC2

(2011) Aleixo M Muise et al.   GUT

Genome-wide methylation profiling in Crohnʼs disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway

(2011) Elaine R. Nimmo et al.   INFLAMMATORY BOWEL DISEASES

Genetics of inflammatory bowel disease in Asia: Systematic review and meta-analysis

(2011) Siew C. Ng et al.   INFLAMMATORY BOWEL DISEASES

miR-143 and miR-145 are downregulated in ulcerative colitis: Putative regulators of inflammation and protooncogenes

(2011) Joel R. Pekow et al.   INFLAMMATORY BOWEL DISEASES

Differential patterns of histone acetylation in inflammatory bowel diseases

(2011) Loukia G Tsaprouni et al.   Journal of Inflammation-London

Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study

(2011) JO Fleming et al.   Multiple Sclerosis Journal

ER stress and the unfolded protein response in intestinal inflammation

(2010) Michael A. McGuckin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Dysbiosis of fecal microbiota in Crohnʼs disease patients as revealed by a custom phylogenetic microarray

(2010) Seungha Kang et al.   INFLAMMATORY BOWEL DISEASES

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

High-Throughput Quantitative Analysis of the Human Intestinal Microbiota with a Phylogenetic Microarray

(2009) O. Paliy et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan

(2009) Chung-Hang Leung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial

(2009) Peter Bager et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Elimination of helminth infection restores HIV-1C vaccine-specific T cell responses independent of helminth-induced IL-10

(2009) Akram A. Da’dara et al.   VACCINE

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Dysbiosis in inflammatory bowel disease: a role for bacteriophages?

(2008) P Lepage et al.   GUT

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Fungi and inflammatory bowel diseases: Alterations of composition and diversity

(2008) Stephan J. Ott et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY