Article
Gastroenterology & Hepatology
Hamed Khalili, Niclas Hakansson, Kevin Casey, Emily Lopes, Jonas F. Ludvigsson, Andrew T. Chan, Simon S. M. Chan, Ola Olen, Alicja Wolk
Summary: This study found that certain healthy eating patterns were associated with a lower risk of older-onset Crohn's disease, but not with the risk of ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Nutrition & Dietetics
Srishti Saha, Neha Patel
Summary: Inflammatory bowel disease (IBD) is a chronic disorder caused by enteric inflammation in a genetically susceptible host. Diet is widely accepted as an important factor in the pathogenesis of IBD, and various dietary components have been studied for their roles in causing enteric inflammation. Different diets, such as exclusive enteral nutrition, specific carbohydrate diet, and low FODMAPs diet, have also been explored for their effects on IBD patients. This review summarizes the current evidence on the relationship between dietary components and IBD, and provides guidance for dietary modifications in managing IBD.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Immunology
Stefania De Santis, Aurelia Scarano, Marina Liso, Francesco Maria Calabrese, Giulio Verna, Elisabetta Cavalcanti, Annamaria Sila, Antonio Lippolis, Maria De Angelis, Angelo Santino, Marcello Chieppa
Summary: The health status of mother microbiota has a significant impact on the neonatal gut microbiota. Using a murine model of UC predisposition, this study evaluated the effects of maternal diet during pregnancy and lactation on offspring microbiota, indicating that a diet enriched with bioactive polyphenols from tomato can reduce dysbiosis in genetically predisposed offspring.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Nutrition & Dietetics
Giacomo Caio, Lisa Lungaro, Fabio Caputo, Eleonora Zoli, Fiorella Giancola, Giuseppe Chiarioni, Roberto De Giorgio, Giorgio Zoli
Summary: Crohn's disease is a chronic inflammatory bowel disease that can cause malnutrition in a significant percentage of patients, highlighting the importance of diet in managing the condition. This review aims to cover recent findings in nutrition for CD treatment, including established diets, new nutritional theories, and advancements in areas like nutrigenomics.
Review
Nutrition & Dietetics
Erik Oudman, Jan W. Wijnia, Misha J. Oey, Mirjam van Dam, Albert Postma
Summary: Crohn's disease and ulcerative colitis patients are at risk of developing Wernicke's encephalopathy due to thiamine depletion, rapid and high-dose thiamine treatment can effectively alleviate symptoms and save lives.
Article
Nutrition & Dietetics
Marcela Guevara, Elena Salamanca-Fernandez, Estrella Miqueleiz, Diana Gavrila, Pilar Amiano, Catalina Bonet, Miguel Rodriguez-Barranco, Jose Maria Huerta, Luis Bujanda, Maria Jose Sanchez, Maria Dolores Chirlaque, Antonio Agudo, Eva Ardanaz, Jesus Castilla
Summary: Results suggest that consuming a more pro-inflammatory diet may contribute to the risk of Crohn's disease, while a healthy diet might be beneficial in its prevention. Further larger studies are needed to verify these findings.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Heather C. Kaplan, Lisa Opipari-Arrigan, Jiabei Yang, Christopher H. Schmid, Christine L. Schuler, Shehzad A. Saeed, Kimberly L. Braly, Fandi Chang, Lauren Murphy, Cassandra M. Dodds, Mason Nuding, Hao Liu, Sheri Pilley, Julie Stone, Gisele Woodward, Nancy Yokois, Alka Goyal, Dale Lee, Ann Ming Yeh, Peter Lee, Benjamin D. Gold, Zarela Molle-Rios, R. Jeff Zwiener, Sabina Ali, Mallory Chavannes, Tiffany Linville, Ashish Patel, Travis Ayers, Mikelle Bassett, Brendan Boyle, Pablo Palomo, Sofia Verstraete, Jill Dorsey, Jess L. Kaplan, Steven J. Steiner, Kaylie Nguyen, Jennifer Burgis, David L. Suskind
Summary: Findings from a study consisting of 54 single-subject trials showed that SCD and MSCD performed similarly for most individuals, with less than 1% probability of a clinically meaningful difference in IBD symptoms between the two diets. Some individuals experienced improvements in symptoms and fecal calprotectin compared with their usual diet, while others did not.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Arshdeep Singh, Vandana Midha, Ramit Mahajan, Shruti Verma, Chandan Kakkar, Jasmine Grover, Dharmatma Singh, Ramandeep Kaur, Abhishek Masih, Namita Bansal, Catherine Wall, Ajit Sood
Summary: Malnutrition and sarcopenia are common in patients with inflammatory bowel disease (IBD), and the prevalence is similar in patients with ulcerative colitis (UC) and Crohn's disease (CD). Threshold values of different parameters of nutritional assessment can be used to identify malnutrition.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Sally Mortlock, Anton Lord, Grant Montgomery, Martha Zakrzewski, Lisa A. Simms, Krupa Krishnaprasad, Katherine Hanigan, James D. Doecke, Alissa Walsh, Ian C. Lawrance, Peter A. Bampton, Jane M. Andrews, Gillian Mahy, Susan J. Connor, Miles P. Sparrow, Sally Bell, Timothy H. Florin, Jakob Begun, Richard B. Gearry, Graham L. Radford-Smith
Summary: This study identified genetic loci associated with medically refractory ulcerative colitis (UC) through a genome wide association analysis. The findings suggest different genetic risk factors for medically refractory UC compared to non-medically refractory UC. Further research may uncover additional loci related to disease severity.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Nutrition & Dietetics
Marta Herrador-Lopez, Rafael Martin-Masot, Victor Manuel Navas-Lopez
Summary: This systematic review and meta-analysis assess the impact of diet on UC management in children and adults. The results indicate higher clinical response, remission, and endoscopic remission rates in diet-treated groups. Different dietary interventions show varying effects in maintaining clinical remission, requiring further research.
Review
Gastroenterology & Hepatology
Ramit Magen-Rimon, Andrew S. Day, Ron Shaoul
Summary: This review summarizes recent reports on nutritional factors relevant to the development of inflammatory bowel disease (IBD) and also reviews data on nutritional deficiencies seen in individuals with IBD.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Immunology
Rachel G. Scheraga, Susamma Abraham, Kathryn A. Niese, Brian D. Southern, Lisa M. Grove, R. Duncan Hite, Christine McDonald, Thomas A. Hamilton, Mitchell A. Olman
JOURNAL OF IMMUNOLOGY
(2016)
Article
Rheumatology
Qingping Yao, Min Shen, Christine McDonald, Felicitas Lacbawan, Rocio Moran, Bo Shen
Article
Gastroenterology & Hepatology
Faris El-Khider, Christine McDonald
DIGESTIVE DISEASES
(2016)
Article
Biochemistry & Molecular Biology
Yeojung Kim, Sean P. Kessler, Dana R. Obery, Craig R. Homer, Christine McDonald, Carol A. de la Motte
Article
Immunology
Christine McDonald, Min Shen, Erin E. Johnson, Amrita Kabi, Qingping Yao
Article
Cell Biology
Sean P. Kessler, Dana R. Obery, Kourtney P. Nickerson, Aaron C. Petrey, Christine McDonald, Carol A. de la Motte
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Samreen Jatana, Craig R. Homer, Maria Madajka, Andras K. Ponti, Amrita Kabi, Francis Papay, Christine McDonald
SCIENTIFIC REPORTS
(2018)
Review
Medicine, Research & Experimental
Megan T. Zangara, Christine McDonald
EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Immunology
Rachel G. Scheraga, Susamma Abraham, Lisa M. Grove, Brian D. Southern, James F. Crish, Apostolos Perelas, Christine McDonald, Kewal Asosingh, Jeffrey D. Hasday, Mitchell A. Olman
JOURNAL OF IMMUNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Megan T. Zangara, Isabel Johnston, Erin E. Johnson, Christine McDonald
Summary: NOD1 and NOD2, in addition to their roles as bacterial sensors, have been implicated in metabolic diseases, showing differential effects in mouse models despite sharing signaling pathway components. These receptors may mediate signaling through cell stressors or metabolic signals in metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Kala K. Mahen, Lilian Markley, Jolie Bogart, Hope Klatka, Vijay Krishna, Edward V. Maytin, George R. Stark, Christine McDonald
Summary: Each year, millions of Americans are diagnosed with non-melanoma skin cancers (NMSC) and millions more receive treatment for precancerous actinic keratosis lesions. The current treatments, surgical excision and Mohs surgery, are invasive, expensive, and require specialized training. More accessible topical therapies exist, but they have significant side effects that limit their effectiveness. Therefore, there is a need for more effective and accessible treatments for NMSC and precancers.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Beckey DeLucia, Sergey Samorezov, Megan T. Zangara, Rachel L. Markley, Lucas J. Osborn, Karlee B. Schultz, Christine McDonald, Jan Claesen
Summary: This article presents a 3D-printed Mouse Intestinal Slicing Tool (MIST) for efficient longitudinal dissection of murine intestines. The MIST outperforms other methods in terms of smoothness and reproducibility, while reducing the time required for intestine preparation.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Megan T. Zangara, Natalie Bhesania, Wei Liu, Gail A. M. Cresci, Jacob A. Kurowski, Christine McDonald
CROHNS & COLITIS 360
(2020)
Article
Gastroenterology & Hepatology
Kourtney P. Nickerson, Rachael Chanin, Christine McDonald