Metal-Catalyzed Direct Difluoromethylation Reactions

Silver-catalyzed fluoroalkylation of thiols using fluoroalkanesulfinates

(2017) Jing-jing Ma et al.   JOURNAL OF FLUORINE CHEMISTRY

Fine Design of Photoredox Systems for Catalytic Fluoromethylation of Carbon–Carbon Multiple Bonds

(2016) Takashi Koike et al.   ACCOUNTS OF CHEMICAL RESEARCH

Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

(2016) Jian Rong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-light-initiated difluoromethylation of arene diazonium tetrafluoroborates

(2016) Ye-bin Wu et al.   CHEMICAL COMMUNICATIONS

Visible-light-mediated radical oxydifluoromethylation of olefinic amides for the synthesis of CF2H-containing heterocycles

(2016) Weijun Fu et al.   CHEMICAL COMMUNICATIONS

Copper-Catalyzed O-Difluoromethylation of Functionalized Aliphatic Alcohols: Access to Complex Organic Molecules with an OCF2H Group

(2016) Kostiantyn Levchenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereoselective Synthesis of CF3- and CF2H-Substituted Spiroethers from Aryl-Fused Cycloalkenylalkanols by Photoredox Catalysis

(2016) Naoki Noto et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible Light Induced Oxydifluoromethylation of Styrenes with Difluoromethyltriphenylphosphonium Bromide

(2016) Yang Ran et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox Catalysis in Organic Chemistry

(2016) Megan H. Shaw et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

(2016) Long Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent

(2016) Hiroki Serizawa et al.   ORGANIC LETTERS

Palladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent

(2016) Kohsuke Aikawa et al.   ORGANIC LETTERS

Photoredox-Catalyzed Intramolecular Difluoromethylation of N-Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H-Containing 2-Azaspiro[4.5]deca-6,9-diene-3,8-diones

(2016) Zuxiao Zhang et al.   ORGANIC LETTERS

Pd-Catalyzed Transfer of Difluorocarbene

(2016) Xiao-Yun Deng et al.   ORGANIC LETTERS

Photoredox-Catalyzed Bromodifluoromethylation of Alkenes with (Difluoromethyl)triphenylphosphonium Bromide

(2016) Qing-Yu Lin et al.   ORGANIC LETTERS

Catalytic Diverse Radical-Mediated 1,2-Cyanofunctionalization of Unactivated Alkenes via Synergistic Remote Cyano Migration and Protected Strategies

(2016) Na Wang et al.   ORGANIC LETTERS

Advances in Photocatalysis: A Microreview of Visible Light Mediated Ruthenium and Iridium Catalyzed Organic Transformations

(2016) Kip Teegardin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Visible Light Photocatalysis: Applications and New Disconnections in the Synthesis of Pharmaceutical Agents

(2016) James J. Douglas et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent advances in photoinduced trifluoromethylation and difluoroalkylation

(2016) Xiaolin Pan et al.   Organic Chemistry Frontiers

Advances in Transition-Metal-Mediated Di-and Monofluoroalkylations

(2015) Chuanfa Ni et al.   ACTA CHIMICA SINICA

Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide

(2015) Qing-Yu Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Difluoromethyl Thioethers from Difluoromethyl Trimethylsilane and Organothiocyanates Generated In Situ

(2015) Bilguun Bayarmagnai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Cu-catalyzed Atom Transfer Radical Addition Reactions of Fluoroalkylsulfonyl Chlorides with Electron-deficient Alkenes Induced by Visible Light

(2015) Xiao-Jun Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Photoredox-Catalyzed Reductive Difluoromethylation of Electron-Deficient Alkenes

(2015) Xiao-Jun Tang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pd-Catalyzed Difluoromethylation of Vinyl Bromides, Triflates, Tosylates, and Nonaflates

(2015) Dalu Chang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2 H-Containing Alcohols

(2015) Yusuke Arai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers

(2015) Marie-Charlotte Belhomme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Difluoromethylation Reaction

(2015) Yang Lu et al.   CURRENT ORGANIC CHEMISTRY

Photocatalytic fluoroalkylation reactions of organic compounds

(2015) Sebastián Barata-Vallejo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent synthetic additions to the visible light photoredox catalysis toolbox

(2015) Ricardo A. Angnes et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fluoroalkylative Aryl Migration of Conjugated N-Arylsulfonylated Amides Using Easily Accessible Sodium Di- and Monofluoroalkanesulfinates

(2015) Zhengbiao He et al.   ORGANIC LETTERS

Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate

(2015) Zhang Feng et al.   ORGANIC LETTERS

Photoredox-Catalyzed Intramolecular Aminodifluoromethylation of Unactivated Alkenes

(2015) Zuxiao Zhang et al.   ORGANIC LETTERS

Photoredox-Catalyzed Tandem Insertion/Cyclization Reactions of Difluoromethyl and 1,1-Difluoroalkyl Radicals with Biphenyl Isocyanides

(2015) Zuxiao Zhang et al.   ORGANIC LETTERS

Well-Defined, Shelf-Stable (NHC)Ag(CF2H) Complexes for Difluoromethylation

(2015) Yang Gu et al.   ORGANOMETALLICS

MnO2-Catalyzed Oxidative Alkylation of Enamides with Ethers via C(sp3)–H/C(sp2)–H Cross-Dehydrogenative Coupling and Hydrolysis Sequence

(2015) Xiangsheng Xu et al.   SYNLETT

Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H

(2015) Sheng-Qing Zhu et al.   Organic Chemistry Frontiers

Catalytic enantioselective organic transformations via visible light photocatalysis

(2015) Chengfeng Wang et al.   Organic Chemistry Frontiers

Oxidative Trifluoromethylation and Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane as a Nucleophilic CF3 Source

(2014) Lingling Chu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Visible Light-Induced Aromatic Difluoroalkylation

(2014) Jaehun Jung et al.   ADVANCED SYNTHESIS & CATALYSIS

Application of Langlois’ Reagent in Trifluoromethylation Reactions

(2014) Cai Zhang   ADVANCED SYNTHESIS & CATALYSIS

Selective difluoroalkylation of alkenes by using visible light photoredox catalysis

(2014) Chunghyeon Yu et al.   CHEMICAL COMMUNICATIONS

Pd(0)-Catalyzed radical aryldifluoromethylation of activated alkenes

(2014) Jian-Yong Wang et al.   CHEMICAL COMMUNICATIONS

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

Fluorinated sulfoximines: syntheses, properties and applications

(2014) Vincent Bizet et al.   CHEMICAL SOCIETY REVIEWS

Dual Catalysis Sees the Light: Combining Photoredox with Organo-, Acid, and Transition-Metal Catalysis

(2014) Matthew N. Hopkinson et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals

(2014) Bing Gao et al.   CHIMIA

Fluorinated Sulfoximines: Preparation, Reactions and Applications

(2014) Xiao Shen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Oxindoles through Silver-Catalyzed Trifluoromethylation-, Difluoromethylation- and Arylsulfonylation-Cyclization Reaction ofN-Arylacrylamides

(2014) Jidan Liu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Direct C-2 Difluoromethylation of Furans and Benzofurans: Access to C-2 CF2H Derivatives

(2014) Marie-Charlotte Belhomme et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd-Catalyzed α-Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes

(2014) Shaozhong Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-catalyzed radical aryldifluoromethylation of activated alkenes to difluoromethylated oxindoles

(2014) Jian-Yong Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organic synthetic transformations using organic dyes as photoredox catalysts

(2014) Shunichi Fukuzumi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent advances in trifluoromethylation of organic compounds using Umemoto's reagents

(2014) Cai Zhang   ORGANIC & BIOMOLECULAR CHEMISTRY

Sandmeyer Difluoromethylation of (Hetero-)Arenediazonium Salts

(2014) Christian Matheis et al.   ORGANIC LETTERS

Visible-Light-Mediated Fluoroalkylation of Isocyanides with Ethyl Bromofluoroacetates: Unified Synthesis of Mono- and Difluoromethylated Phenanthridine Derivatives

(2014) Xiaoyang Sun et al.   ORGANIC LETTERS

Photoredox-Catalyzed Tandem Radical Cyclization of N-Arylacrylamides: General Methods To Construct Fluorinated 3,3-Disubstituted 2-Oxindoles Using Fluoroalkylsulfonyl Chlorides

(2014) Xiao-Jun Tang et al.   ORGANIC LETTERS

Visible Light-Mediated C–H Difluoromethylation of Electron-Rich Heteroarenes

(2014) Yi-Ming Su et al.   ORGANIC LETTERS

Synthesis of Fluoroalkyl Palladium and Nickel Complexes via Decarbonylation of Acylmetal Species

(2014) Ansis Maleckis et al.   ORGANOMETALLICS

Trifluoromethylation by Visible-Light-Driven Photoredox Catalysis

(2014) Takashi Koike et al.   TOPICS IN CATALYSIS

Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides

(2014) Yang Gu et al.   Nature Communications

Visible-light radical reaction designed by Ru- and Ir-based photoredox catalysis

(2014) Takashi Koike et al.   Inorganic Chemistry Frontiers

Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

(2014) Xue-Liang Jiang et al.   Organic Chemistry Frontiers

Direct Trifluoromethylation of the CH Bond

(2013) Hui Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Photoredox Catalysis for Organic Syntheses

(2013) Melissa Reckenthäler et al.   ADVANCED SYNTHESIS & CATALYSIS

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Applications of Visible Light Photoredox Catalysis in Organic Synthesis

(2013) Xiaojun Dai et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Synthetic applications of photoredox catalysis with visible light

(2013) Yumeng Xi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper- and Iron-Catalyzed Decarboxylative Tri- and Difluoromethylation of α,β-Unsaturated Carboxylic Acids with CF3SO2Na and (CF2HSO2)2Zn via a Radical Process

(2013) Zejiang Li et al.   ORGANIC LETTERS

Reactions of Difluorocarbene with Organozinc Reagents

(2013) Vitalij V. Levin et al.   ORGANIC LETTERS

Recent Advances in Transition-Metal-Catalyzed Trifluoromethylation and Related Transformations

(2013) Guosheng Liu et al.   SYNTHESIS-STUTTGART

Recent Applications of Organic Dyes as Photoredox Catalysts in Organic Synthesis

(2013) David A. Nicewicz et al.   ACS Catalysis

Copper-Catalyzed Difluoromethylation of β,γ-Unsaturated Carboxylic Acids: An Efficient Allylic Difluoromethylation

(2012) Zhengbiao He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light Photoredox Catalysis

(2012) Jun Xuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane

(2012) G. K. Surya Prakash et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Developments on the Trifluoromethylation of (Hetero)Arenes

(2012) Xiao-Feng Wu et al.   Chemistry-An Asian Journal

Palladium-Mediated Heck-Type Reactions of [(Bromodifluoromethyl)sulfonyl]benzene: Synthesis of α-Alkenyl- and α-Heteroaryl-Substituted α,α-Difluoromethyl Phenyl Sulfones

(2012) Nakin Surapanich et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Shining Light on Photoredox Catalysis: Theory and Synthetic Applications

(2012) Joseph W. Tucker et al.   JOURNAL OF ORGANIC CHEMISTRY

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Cobalt Fluorocarbene Complexes

(2012) Daniel J. Harrison et al.   ORGANOMETALLICS

An Efficient Route to Difluoromethylated Pyridines

(2012) Hideki Amii et al.   SYNTHESIS-STUTTGART

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

A New Method for Aromatic Difluoromethylation: Copper-Catalyzed Cross-Coupling and Decarboxylation Sequence from Aryl Iodides

(2011) Kenichi Fujikawa et al.   ORGANIC LETTERS

Innate C-H trifluoromethylation of heterocycles

(2011) Y. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination Catalysis in Enantioselective Trifluoromethylation

(2010) Yan Zheng et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

Visible light photoredox catalysis: applications in organic synthesis

(2010) Jagan M. R. Narayanam et al.   CHEMICAL SOCIETY REVIEWS

Visible light photocatalysis as a greener approach to photochemical synthesis

(2010) Tehshik P. Yoon et al.   Nature Chemistry

Selective difluoromethylation and monofluoromethylation reactions

(2009) Jinbo Hu et al.   CHEMICAL COMMUNICATIONS

Nucleophilic, radical, and electrophilic (phenylsulfonyl)difluoromethylations

(2009) Jinbo Hu   JOURNAL OF FLUORINE CHEMISTRY

Synthesis of Celecoxib Analogues Possessing aN-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity

(2009) Morshed A. Chowdhury et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles

(2009) Wei Zhang et al.   ORGANIC LETTERS

Recent advances in enantioselective trifluoromethylation reactions

(2009) Norio Shibata et al.   TETRAHEDRON-ASYMMETRY