Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers

Advances in Transition-Metal-Mediated Di-and Monofluoroalkylations

(2015) Chuanfa Ni et al.   ACTA CHIMICA SINICA

Heterogeneous Platinum-Catalyzed CH Perfluoroalkylation of Arenes and Heteroarenes

(2015) Lin He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-Catalyzed Difluoromethylation of Vinyl Bromides, Triflates, Tosylates, and Nonaflates

(2015) Dalu Chang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed Innate Ethoxycarbon­yldifluoromethylation of Electron-Rich ­Arenes

(2015) Marie-Charlotte Belhomme et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Direct Vicinal Difunctionalization of Alkynes: An Efficient Approach Towards the Synthesis of Highly Functionalized Fluorinated Alkenes

(2015) Tatiana Besset et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids

(2015) Ji-Wei Gu et al.   Organic Chemistry Frontiers

Visible Light-Induced Aromatic Difluoroalkylation

(2014) Jaehun Jung et al.   ADVANCED SYNTHESIS & CATALYSIS

A General Synthesis of Fluoroalkylated Alkenes by Palladium-Catalyzed Heck-Type Reaction of Fluoroalkyl Bromides

(2014) Zhang Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives

(2014) Zhang Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of α,α-Difluoromethylene Alkynes by Palladium-Catalyzedgem-Difluoropropargylation of Aryl and Alkenyl Boron Reagents

(2014) Yan-Bo Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Intramolecular CH Difluoroalkylation: Synthesis of Substituted 3,3-Difluoro-2-oxindoles

(2014) Shi-Liang Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups

(2014) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes

(2014) Yu-Lan Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct C–H difluoromethylenephosphonation of arenes and heteroarenes with bromodifluoromethyl phosphonate via visible-light photocatalysis

(2014) Lin Wang et al.   CHEMICAL COMMUNICATIONS

Copper-catalyzed olefinic C–H difluoroacetylation of enamides

(2014) Gilles Caillot et al.   CHEMICAL COMMUNICATIONS

Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids

(2014) Guobin Ma et al.   CHEMICAL COMMUNICATIONS

Modern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis

(2014) Michael G. Campbell et al.   CHEMICAL REVIEWS

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

(2014) David O’Hagan et al.   CHEMICAL REVIEWS

Beyond the Balz–Schiemann Reaction: The Utility of Tetrafluoroborates and Boron Trifluoride as Nucleophilic Fluoride Sources

(2014) Alexander J. Cresswell et al.   CHEMICAL REVIEWS

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

(2014) Estíbaliz Merino et al.   CHEMICAL SOCIETY REVIEWS

Recent Progress in Direct Introduction of Fluorinated Groups on Alkenes and Alkynes by means of CH Bond Functionalization

(2014) Tatiana Besset et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enhancement of Neighbouring-Group Participation in Cu0-Promoted Cross-Couplinggem-Difluoromethylenation of Aryl/Alkenyl Halides with 1,3-Azolic Difluoromethyl Bromides

(2014) Haizhen Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

(2014) Gregory Landelle et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Access to Difluoromethylated Alkynes through the Castro-Stephens Reaction

(2014) Tatiana Besset et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Direct C-2 Difluoromethylation of Furans and Benzofurans: Access to C-2 CF2H Derivatives

(2014) Marie-Charlotte Belhomme et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd-Catalyzed α-Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes

(2014) Shaozhong Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-Catalyzed α-Arylation of Trimethylsilyl Enolates of α,α-Difluoroacetamides

(2014) Shaozhong Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Selective gem-Difluoroallylation of Organoborons with Bromodifluoromethylated Alkenes Catalyzed by Palladium

(2014) Qiao-Qiao Min et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heteroaryldifluoromethylation of Organoborons Catalyzed by Palladium: Facile Access to Aryl(Heteroaryl)difluoromethanes

(2014) Yu-Lan Xiao et al.   ORGANIC LETTERS

Sandmeyer Difluoromethylation of (Hetero-)Arenediazonium Salts

(2014) Christian Matheis et al.   ORGANIC LETTERS

Visible Light-Mediated C–H Difluoromethylation of Electron-Rich Heteroarenes

(2014) Yi-Ming Su et al.   ORGANIC LETTERS

Visible-Light-Driven Difluoroacetamidation of Unactive Arenes and Heteroarenes by Direct C–H Functionalization at Room Temperature

(2014) Lin Wang et al.   ORGANIC LETTERS

Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides

(2014) Yang Gu et al.   Nature Communications

Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

(2014) Xue-Liang Jiang et al.   Organic Chemistry Frontiers

Direct Synthesis of Fluorinated Heteroarylether Bioisosteres

(2013) Qianghui Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

(2013) Grégory Landelle et al.   Beilstein Journal of Organic Chemistry

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Chemicals from Alkynes with Palladium Catalysts

(2013) Rafael Chinchilla et al.   CHEMICAL REVIEWS

Direct Introduction of Ethoxycarbonyldifluoromethyl-Group to Heteroarenes with Ethyl Bromodifluoroacetate via Visible-Light Photocatalysis

(2013) Qingyu Lin et al.   CHINESE JOURNAL OF CHEMISTRY

Diethylzinc-Mediated Addition of 2,2-Dibromo-2-fluoroacetamides to Carbonyl Compounds: Synthesis of α-Bromo-α-fluoro-β-hydroxy Amides and/or (Z)-Fluorovinyl Amides

(2013) Gérald Lemonnier et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Copper-Mediated, Palladium-Catalyzed Cross-Coupling of 3-Iodochromones, Thiochromones, and Quinolones with Ethyl Bromodifluoroacetate

(2013) Xiaodong Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Cupration of C2F5H: Isolation, Structure, and Synthetic Applications of [K(DMF)2][(t-BuO)Cu(C2F5)]. Highly Efficient Pentafluoroethylation of Unactivated Aryl Bromides

(2013) Anton Lishchynskyi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-mediated oxidative difluoromethylenation of aryl boronic acids with α-silyldifluoromethylphosphonates: a new method for aryldifluorophosphonates

(2013) Xueliang Jiang et al.   NEW JOURNAL OF CHEMISTRY

Copper Catalyzed β-Difluoroacetylation of Dihydropyrans and Glycals by Means of Direct C–H Functionalization

(2013) Marie-Charlotte Belhomme et al.   ORGANIC LETTERS

Copper- and Iron-Catalyzed Decarboxylative Tri- and Difluoromethylation of α,β-Unsaturated Carboxylic Acids with CF3SO2Na and (CF2HSO2)2Zn via a Radical Process

(2013) Zejiang Li et al.   ORGANIC LETTERS

Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes

(2013) Satoshi Mizuta et al.   ORGANIC LETTERS

Cobalt-catalyzed cross-coupling reaction of arylzinc reagents with ethyl bromodifluoroacetate

(2013) Keisuke Araki et al.   TETRAHEDRON

Copper-catalyzed cross-coupling of bromozinc-difluoromethylphosphonate with iodo/bromo-aryl triazenes

(2013) Zhang Feng et al.   Organic Chemistry Frontiers

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane

(2012) G. K. Surya Prakash et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct CH Functionalization of Enamides and Enecarbamates by Using Visible-Light Photoredox Catalysis

(2012) Heng Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Mediated Heck-Type Reactions of [(Bromodifluoromethyl)sulfonyl]benzene: Synthesis of α-Alkenyl- and α-Heteroaryl-Substituted α,α-Difluoromethyl Phenyl Sulfones

(2012) Nakin Surapanich et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Palladium catalyzed direct α-arylation of α,α-difluoroketones with aryl bromides

(2012) Chen Guo et al.   JOURNAL OF FLUORINE CHEMISTRY

Nanomolar Potency and Metabolically Stable Inhibitors of Kidney Urea Transporter UT-B

(2012) Marc O. Anderson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Mediated Aerobic Fluoroalkylation of Arylboronic Acids with Fluoroalkyl Iodides at Room Temperature

(2012) Qingqing Qi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient synthesis of unsymmetrical S-(bromodifluoromethyl)diarylsulfonium salts for electrophilic bromodifluoromethylating reagents

(2012) Guokai Liu et al.   NEW JOURNAL OF CHEMISTRY

Copper-Mediated Oxidative Cross-Coupling Reaction of Terminal Alkynes with α-Silyldifluoromethylphosphonates: An Efficient Method for α,α-Difluoropropargylphosphonates

(2012) Xueliang Jiang et al.   ORGANIC LETTERS

Copper Catalyzed Cross-Coupling of Iodobenzoates with Bromozinc-difluorophosphonate

(2012) Zhang Feng et al.   ORGANIC LETTERS

Copper-catalyzed decarboxylative alkenylation of sp3 C–H bonds with cinnamic acids via a radical process

(2012) Zili Cui et al.   Chemical Science

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Difluoromethylation of O-, S-, N-, C-Nucleophiles Using Difluoromethyltri(n-butyl)ammonium Chloride as a New Difluorocarbene Source

(2011) Fei Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies PotentPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

(2011) Jose M. Coteron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

A New Method for Aromatic Difluoromethylation: Copper-Catalyzed Cross-Coupling and Decarboxylation Sequence from Aryl Iodides

(2011) Kenichi Fujikawa et al.   ORGANIC LETTERS

Direct ethoxycarbonyldifluoromethylation of aromatic compounds using Fenton reagent

(2011) Yuhki Ohtsuka et al.   TETRAHEDRON

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

Copper-Mediated Fluoroalkylation Reactions with Iododifluoroacetamides: Controlling the Selectivity among Cross-Coupling, Intramolecular Cyclization, and Homocoupling Reactions

(2010) Jieming Zhu et al.   JOURNAL OF ORGANIC CHEMISTRY

The Organometallic Fluorine Chemistry of Palladium and Rhodium: Studies toward Aromatic Fluorination

(2009) Vladimir V. Grushin   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-d-aspartate receptors☆

(2009) Cara A. Mosley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective difluoromethylation and monofluoromethylation reactions

(2009) Jinbo Hu et al.   CHEMICAL COMMUNICATIONS

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles

(2009) Wei Zhang et al.   ORGANIC LETTERS

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS