Cyclic-di-GMP regulation of virulence in bacterial pathogens

Cyclic Di-GMP Binding by an Assembly ATPase (PilB2) and Control of Type IV Pilin Polymerization in the Gram-Positive Pathogen Clostridium perfringens

(2017) William A. Hendrick et al.   JOURNAL OF BACTERIOLOGY

Cholera

(2017) John D Clemens et al.   LANCET

Versatile modes of cellular regulation via cyclic dinucleotides

(2017) Petya Violinova Krasteva et al.   Nature Chemical Biology

Clostridium difficile disease: Diagnosis, pathogenesis, and treatment update

(2017) Lena M. Napolitano et al.   SURGERY

Psl Produced by Mucoid Pseudomonas aeruginosa Contributes to the Establishment of Biofilms and Immune Evasion

(2017) Christopher J. Jones et al.   mBio

Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host

(2017) Maite Echeverz et al.   PLoS Genetics

Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion

(2017) Ronan R. McCarthy et al.   Nature Microbiology

Virulence factors of Clostridium difficile and their role during infection

(2016) Claire Janoir   ANAEROBE

Salmonella Extracellular Matrix Components Influence Biofilm Formation and Gallbladder Colonization

(2016) Haley E. Adcox et al.   INFECTION AND IMMUNITY

PilZ Domain Protein FlgZ Mediates Cyclic Di-GMP-Dependent Swarming Motility Control in Pseudomonas aeruginosa

(2016) Amy E. Baker et al.   JOURNAL OF BACTERIOLOGY

Vfr Directly ActivatesexsATranscription To Regulate Expression of the Pseudomonas aeruginosa Type III Secretion System

(2016) Anne E. Marsden et al.   JOURNAL OF BACTERIOLOGY

A Cyclic di-GMP-binding Adaptor Protein Interacts with Histidine Kinase to Regulate Two-component Signaling

(2016) Linghui Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance inStaphylococcus aureus

(2016) Lisa Bowman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons fromPseudomonas aeruginosaand Other Bacteria

(2016) Martina Valentini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BcsZ inhibits biofilm phenotypes and promotes virulence by blocking cellulose production in Salmonella enterica serovar Typhimurium

(2016) Irfan Ahmad et al.   Microbial Cell Factories

Klebsiella pneumoniae: Going on the Offense with a Strong Defense

(2016) Michelle K. Paczosa et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A cyclic di-GMP-binding adaptor protein interacts with a chemotaxis methyltransferase to control flagellar motor switching

(2016) L. Xu et al.   Science Signaling

Salmonella Typhimurium and Multidirectional Communication in the Gut

(2016) Elena V. Gart et al.   Frontiers in Microbiology

A cyclic di-GMP-binding adaptor protein interacts with a chemotaxis methyltransferase to control flagellar motor switching

(2016) L. Xu et al.   Science Signaling

Cyclic-di-GMP signaling in the Gram-positive pathogen Clostridium difficile

(2015) Eric Bordeleau et al.   CURRENT GENETICS

Dissecting the cyclic di-guanylate monophosphate signalling network regulating motility inSalmonella entericaserovar Typhimurium

(2015) Soazig Le Guyon et al.   ENVIRONMENTAL MICROBIOLOGY

Temperature affects c-di-GMP signalling and biofilm formation inVibrio cholerae

(2015) Loni Townsley et al.   ENVIRONMENTAL MICROBIOLOGY

Bistable Expression of CsgD in Salmonella enterica Serovar Typhimurium Connects Virulence to Persistence

(2015) Keith D. MacKenzie et al.   INFECTION AND IMMUNITY

Cyclic di-GMP Modulates Gene Expression in Lyme Disease Spirochetes at the Tick-Mammal Interface To Promote Spirochete Survival during the Blood Meal and Tick-to-Mammal Transmission

(2015) Melissa J. Caimano et al.   INFECTION AND IMMUNITY

Risk Factors for Recurrent Clostridium difficile Infection: A Systematic Review and Meta-Analysis

(2015) Abhishek Deshpande et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Genome-Based Comparison of Cyclic Di-GMP Signaling in Pathogenic and Commensal Escherichia coli Strains

(2015) Tatyana L. Povolotsky et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-GMP Signaling Contributes to Pseudomonas aeruginosa-Mediated Catheter-Associated Urinary Tract Infection

(2015) Stephanie J. Cole et al.   JOURNAL OF BACTERIOLOGY

FleQ DNA Binding Consensus Sequence Revealed by Studies of FleQ-Dependent Regulation of Biofilm Gene Expression in Pseudomonas aeruginosa

(2015) Claudine Baraquet et al.   JOURNAL OF BACTERIOLOGY

Cyclic diGMP Regulates Production of Sortase Substrates ofClostridium difficileand Their Surface Exposure through ZmpI Protease-mediated Cleavage

(2015) Johann Peltier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligoribonuclease is a central feature of cyclic diguanylate signaling inPseudomonas aeruginosa

(2015) Dorit Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligoribonuclease is the primary degradative enzyme for pGpG inPseudomonas aeruginosathat is required for cyclic-di-GMP turnover

(2015) Mona W. Orr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ fromPseudomonas aeruginosa

(2015) Bruno Y. Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Colonization Dynamics of Vibrio cholerae

(2015) Salvador Almagro-Moreno et al.   PLoS Pathogens

C-di-GMP Regulates Motile to Sessile Transition by Modulating MshA Pili Biogenesis and Near-Surface Motility Behavior in Vibrio cholerae

(2015) Christopher J. Jones et al.   PLoS Pathogens

Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems

(2015) Kevin G. Roelofs et al.   PLoS Pathogens

Deletion Mutant Library for Investigation of Functional Outputs of Cyclic Diguanylate Metabolism in Pseudomonas aeruginosa PA14

(2014) Dae-Gon Ha et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cyclic-di-GMP signalling and biofilm-related properties of the Shiga toxin-producing 2011 German outbreak Escherichia coli O104:H4

(2014) A. M. Richter et al.   EMBO Molecular Medicine

Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile

(2014) Eric Bordeleau et al.   JOURNAL OF BACTERIOLOGY

A Novel Secreted Metalloprotease (CD2830) fromClostridium difficileCleaves Specific Proline Sequences in LPXTG Cell Surface Proteins

(2014) Paul J. Hensbergen et al.   MOLECULAR & CELLULAR PROTEOMICS

GIL, a new c-di-GMP-binding protein domain involved in regulation of cellulose synthesis in enterobacteria

(2014) Xin Fang et al.   MOLECULAR MICROBIOLOGY

BrlR fromPseudomonas aeruginosais a c-di-GMP-responsive transcription factor

(2014) Jacob R. Chambers et al.   MOLECULAR MICROBIOLOGY

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP

(2014) Jacob L W Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi

(2014) Elizabeth A. Novak et al.   Frontiers in Cellular and Infection Microbiology

Review: Unraveling Lyme Disease

(2014) Linda K. Bockenstedt et al.   Arthritis & Rheumatology

Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation

(2013) A. Fabrega et al.   CLINICAL MICROBIOLOGY REVIEWS

Genetic Analysis of the Role ofyfiRin the Ability of Escherichia coli CFT073 To Control Cellular Cyclic Dimeric GMP Levels and To Persist in the Urinary Tract

(2013) Erica L. Raterman et al.   INFECTION AND IMMUNITY

Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

(2013) Louise D. Christensen et al.   INFECTION AND IMMUNITY

The Second Messenger Cyclic Di-GMP Regulates Clostridium difficile Toxin Production by Controlling Expression of sigD

(2013) R. W. McKee et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Cyclic di-GMP inhibitsVibrio choleraemotility by repressing induction of transcription and inducing extracellular polysaccharide production

(2013) Disha Srivastava et al.   MOLECULAR MICROBIOLOGY

YjcC, a c-di-GMP Phosphodiesterase Protein, Regulates the Oxidative Stress Response and Virulence of Klebsiella pneumoniae CG43

(2013) Ching-Jou Huang et al.   PLoS One

Transcriptional Activation of the mrkA Promoter of the Klebsiella pneumoniae Type 3 Fimbrial Operon by the c-di-GMP-Dependent MrkH Protein

(2013) Ji Yang et al.   PLoS One

Identification of a Novel Zinc Metalloprotease through a Global Analysis of Clostridium difficile Extracellular Proteins

(2013) Valeria Cafardi et al.   PLoS One

Characterization of the SigD Regulon of C. difficile and Its Positive Control of Toxin Production through the Regulation of tcdR

(2013) Imane El Meouche et al.   PLoS One

Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ

(2013) C. Baraquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-di-GMP signaling regulates E. coli O157:H7 adhesion to colonic epithelium

(2013) Jia Hu et al.   VETERINARY MICROBIOLOGY

Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile

(2013) Olga A. Soutourina et al.   PLoS Genetics

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

(2013) Shaan L. Gellatly et al.   Pathogens and Disease

Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae

(2012) Diana P Cruz et al.   BMC MICROBIOLOGY

Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction

(2012) Samuel Steiner et al.   EMBO JOURNAL

Transcriptional Modulation of Enterotoxigenic Escherichia coli Virulence Genes in Response to Epithelial Cell Interactions

(2012) Rita Kansal et al.   INFECTION AND IMMUNITY

Modulation of Toxin Production by the Flagellar Regulon in Clostridium difficile

(2012) Annie Aubry et al.   INFECTION AND IMMUNITY

Cyclic Diguanylate Inversely Regulates Motility and Aggregation in Clostridium difficile

(2012) E. B. Purcell et al.   JOURNAL OF BACTERIOLOGY

Structures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation inPseudomonas aeruginosaPAO1

(2012) Zhi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production inPseudomonas aeruginosa

(2012) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clostridium difficile flagellin stimulates toll-like receptor 5, and toxin B promotes flagellin-induced chemokine production via TLR5

(2012) Yusuke Yoshino et al.   LIFE SCIENCES

The response threshold ofSalmonellaPilZ domain proteins is determined by their binding affinities for c-di-GMP

(2012) Ingrid Swanson Pultz et al.   MOLECULAR MICROBIOLOGY

Enzymatically Active and Inactive Phosphodiesterases and Diguanylate Cyclases Are Involved in Regulation of Motility or Sessility in Escherichia coli CFT073

(2012) R. R. Spurbeck et al.   mBio

The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways

(2012) Jacob G. Malone et al.   PLoS Pathogens

Analysis of the Borrelia burgdorferi Cyclic-di-GMP-Binding Protein PlzA Reveals a Role in Motility and Virulence

(2011) Joshua E. Pitzer et al.   INFECTION AND IMMUNITY

Direct Evaluation of Pseudomonas aeruginosa Biofilm Mediators in a Chronic Infection Model

(2011) Matthew S. Byrd et al.   INFECTION AND IMMUNITY

Analysis of the HD-GYP Domain Cyclic Dimeric GMP Phosphodiesterase Reveals a Role in Motility and the Enzootic Life Cycle of Borrelia burgdorferi

(2011) Syed Z. Sultan et al.   INFECTION AND IMMUNITY

The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks

(2011) Melissa J. Caimano et al.   INFECTION AND IMMUNITY

Integration of Cyclic di-GMP and Quorum Sensing in the Control of vpsT and aphA in Vibrio cholerae

(2011) Disha Srivastava et al.   JOURNAL OF BACTERIOLOGY

Type 3 Fimbriae and Biofilm Formation Are Regulated by the Transcriptional Regulators MrkHI in Klebsiella pneumoniae

(2011) J. G. Johnson et al.   JOURNAL OF BACTERIOLOGY

The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes

(2011) Jessica L. Kostick et al.   MOLECULAR MICROBIOLOGY

Differential Control of Yersinia pestis Biofilm Formation In Vitro and in the Flea Vector by Two c-di-GMP Diguanylate Cyclases

(2011) Yi-Cheng Sun et al.   PLoS One

Complex c-di-GMP Signaling Networks Mediate Transition between Virulence Properties and Biofilm Formation in Salmonella enterica Serovar Typhimurium

(2011) Irfan Ahmad et al.   PLoS One

Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks

(2011) Ming He et al.   PLoS Pathogens

MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression

(2011) Jonathan J. Wilksch et al.   PLoS Pathogens

Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity

(2010) Alex Boehm et al.   CELL

In Vitro and In Vivo Characterization of the Pseudomonas aeruginosa Cyclic AMP (cAMP) Phosphodiesterase CpdA, Required for cAMP Homeostasis and Virulence Factor Regulation

(2010) E. L. Fuchs et al.   JOURNAL OF BACTERIOLOGY

Role of MrkJ, a Phosphodiesterase, in Type 3 Fimbrial Expression and Biofilm Formation in Klebsiella pneumoniae

(2010) J. G. Johnson et al.   JOURNAL OF BACTERIOLOGY

The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism

(2010) Koushik Paul et al.   MOLECULAR CELL

Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis

(2010) Alexander G. Bobrov et al.   MOLECULAR MICROBIOLOGY

Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence

(2010) Syed Z. Sultan et al.   MOLECULAR MICROBIOLOGY

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

Quorum-regulated biofilms enhance the development of conditionally viable, environmental Vibrio cholerae

(2010) M. Kamruzzaman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger

(2010) E. R. Lee et al.   SCIENCE

Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP

(2010) P. V. Krasteva et al.   SCIENCE

Cyclic di-GMP signalling controls virulence properties ofSalmonella entericaserovar Typhimurium at the mucosal lining

(2009) Agaristi Lamprokostopoulou et al.   ENVIRONMENTAL MICROBIOLOGY

Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete,Borrelia burgdorferi

(2009) John C. Freedman et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Genetic Requirements for Klebsiella pneumoniae-Induced Liver Abscess in an Oral Infection Model

(2009) Y.-C. Tu et al.   INFECTION AND IMMUNITY

A Role for the EAL-Like Protein STM1344 in Regulation of CsgD Expression and Motility in Salmonella enterica Serovar Typhimurium

(2009) R. Simm et al.   JOURNAL OF BACTERIOLOGY

Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung

(2009) M. Starkey et al.   JOURNAL OF BACTERIOLOGY

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Vibrio biofilms: so much the same yet so different

(2009) Fitnat H. Yildiz et al.   TRENDS IN MICROBIOLOGY

Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths

(2009) Marie Touchon et al.   PLoS Genetics

Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli

(2008) C. Pesavento et al.   GENES & DEVELOPMENT

Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007

(2008) Alicia I. Hidron et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

The Pangenome Structure of Escherichia coli: Comparative Genomic Analysis of E. coli Commensal and Pathogenic Isolates

(2008) D. A. Rasko et al.   JOURNAL OF BACTERIOLOGY

Identification of FleQ fromPseudomonas aeruginosaas a c-di-GMP-responsive transcription factor

(2008) Jason W. Hickman et al.   MOLECULAR MICROBIOLOGY

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

(2008) N. Sudarsan et al.   SCIENCE