Genetic variation in human drug-related genes

Mutation effects predicted from sequence co-variation

(2017) Thomas A Hopf et al.   NATURE BIOTECHNOLOGY

A Landscape of Pharmacogenomic Interactions in Cancer

(2016) Francesco Iorio et al.   CELL

Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network

(2016) WS Bush et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeted Next-Generation Sequencing for Comprehensive Genetic Profiling of Pharmacogenes

(2016) SM Han et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Rare genetic variants in cellular transporters, metabolic enzymes and nuclear receptors can be important determinants of interindividual differences in drug response

(2016) Mikael Kozyra et al.   GENETICS IN MEDICINE

Getting Pharmacogenomics Into the Clinic

(2016) Jennifer Abbasi   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacogenetics: The right drug for you

(2016) Liam Drew   NATURE

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer

(2016) Guomin Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Warfarin and vitamin K compete for binding to Phe55 in human VKOR

(2016) Katrin J Czogalla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SNPs associated with activity and toxicity of cabazitaxel in patients with advanced urothelial cell carcinoma

(2016) Ignacio Duran et al.   PHARMACOGENOMICS

The global spectrum of protein-coding pharmacogenomic diversity

(2016) G E B Wright et al.   PHARMACOGENOMICS JOURNAL

Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer

(2016) Guomin Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Warfarin and vitamin K compete for binding to Phe55 in human VKOR

(2016) Katrin J Czogalla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers

(2015) Henry M. Dunnenberger et al.   Annual Review of Pharmacology and Toxicology

In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities

(2015) Carlota Rubio-Perez et al.   CANCER CELL

Pharmacogenomics of long-acting β2-agonists

(2015) Kathryn Blake et al.   Expert Opinion on Drug Metabolism & Toxicology

The Evaluation of Tools Used to Predict the Impact of Missense Variants Is Hindered by Two Types of Circularity

(2015) Dominik G. Grimm et al.   HUMAN MUTATION

Trends in Prescription Drug Use Among Adults in the United States From 1999-2012

(2015) Elizabeth D. Kantor et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacogenomics in the clinic

(2015) Mary V. Relling et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Personalized medicine: Time for one-person trials

(2015) Nicholas J. Schork   NATURE

Genetic variation in the human cytochrome P450 supergene family

(2015) Kohei Fujikura et al.   Pharmacogenetics and Genomics

Computational discovery of transcription factors associated with drug response

(2015) C Hanson et al.   PHARMACOGENOMICS JOURNAL

Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing

(2015) A Tourancheau et al.   PHARMACOGENOMICS JOURNAL

Distance from sub-Saharan Africa predicts mutational load in diverse human genomes

(2015) Brenna M. Henn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patterns and functional implications of rare germline variants across 12 cancer types

(2015) Charles Lu et al.   Nature Communications

Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions

(2014) Munir Pirmohamed   Annual Review of Genomics and Human Genetics

UniRef clusters: a comprehensive and scalable alternative for improving sequence similarity searches

(2014) B. E. Suzek et al.   BIOINFORMATICS

Mechanisms and assessment of statin-related muscular adverse effects

(2014) Dirk Moßhammer et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

(2014) Gregory M. Alushin et al.   CELL

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Deep mutational scanning: a new style of protein science

(2014) Douglas M Fowler et al.   NATURE METHODS

Comprehensive mutational scanning of a kinasein vivoreveals substrate-dependent fitness landscapes

(2014) Alexandre Melnikov et al.   NUCLEIC ACIDS RESEARCH

NOS2 Variants Reveal a Dual Genetic Control of Nitric Oxide Levels, Susceptibility to Plasmodium Infection, and Cerebral Malaria

(2013) Maria de Jesus Trovoada et al.   INFECTION AND IMMUNITY

Pharmacogenetics: Implications of race and ethnicity on defining genetic profiles for personalized medicine

(2013) Victor E. Ortega et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Next-generation sequencing of pharmacogenes

(2013) Britt I. Drögemöller et al.   Pharmacogenetics and Genomics

Pharmacogenomics, ancestry and clinical decision making for global populations

(2013) E Ramos et al.   PHARMACOGENOMICS JOURNAL

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

A practical method to detect SNVs and indels from whole genome and exome sequencing data

(2013) Daichi Shigemizu et al.   Scientific Reports

Pharmacogenomics Knowledge for Personalized Medicine

(2012) M Whirl-Carrillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogenomics and public health: implementing ‘populationalized’ medicine

(2012) Lindsey Mette et al.   PHARMACOGENOMICS

An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

(2012) M. R. Nelson et al.   SCIENCE

A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

(2012) D. G. MacArthur et al.   SCIENCE

Relating human genetic variation to variation in drug responses

(2012) Ashraf G. Madian et al.   TRENDS IN GENETICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing

(2011) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogenetics, Pharmacogenomics, and Individualized Medicine

(2011) Q. Ma et al.   PHARMACOLOGICAL REVIEWS

Protein 3D Structure Computed from Evolutionary Sequence Variation

(2011) Debora S. Marks et al.   PLoS One

Copy number variants in pharmacogenetic genes

(2011) Yijing He et al.   TRENDS IN MOLECULAR MEDICINE

Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers,

(2010) Ranjinder S. Sidhu et al.   BIOCHEMISTRY

Hidden Markov model speed heuristic and iterative HMM search procedure

(2010) L Steven Johnson et al.   BMC BIOINFORMATICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Genome-wide association studies in pharmacogenomics

(2010) Ann K. Daly   NATURE REVIEWS GENETICS

VKORC1 Pharmacogenomics Summary

(2010) Ryan P. Owen et al.   Pharmacogenetics and Genomics

Genome-wide association studies in pharmacogenomics

(2010) Alison A. Motsinger-Reif et al.   Pharmacogenetics and Genomics

Cancer Pharmacoethnicity: Ethnic Differences in Susceptibility to the Effects of Chemotherapy

(2009) P. H. O'Donnell et al.   CLINICAL CANCER RESEARCH

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Very important pharmacogene summary ADRB2

(2009) Augusto A. Litonjua et al.   Pharmacogenetics and Genomics

The Role of Ethnicity in Variability in Response to Drugs: Focus on Clinical Pharmacology Studies

(2008) SU Yasuda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients

(2008) Ross A. Soo et al.   LUNG CANCER