Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer’s Disease

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

(2018) Teodoro del Ser et al.   JOURNAL OF ALZHEIMERS DISEASE

AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats

(2018) Lai-Ling Du et al.   JOURNAL OF ALZHEIMERS DISEASE

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

(2017) Jakub Jeřábek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dietary fat composition, food matrix and relative polarity modulate the micellarization and intestinal uptake of carotenoids from vegetables and fruits

(2017) Purna Chandra Mashurabad et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Trans -crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients

(2017) Roberto Tiribuzi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cognitive impairment is correlated with insulin resistance degree: the “PA-NICO-study”

(2017) Antonietta Fava et al.   METABOLIC BRAIN DISEASE

FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects

(2017) Haibiao Guo et al.   NEUROPHARMACOLOGY

The Isothiocyanate Isolated fromMoringa oleiferaShows Potent Anti-Inflammatory Activity in the Treatment of Murine Subacute Parkinson's Disease

(2017) Sabrina Giacoppo et al.   REJUVENATION RESEARCH

Use of T1-weighted/T2-weighted magnetic resonance ratio to elucidate changes due to amyloid β accumulation in cognitively normal subjects

(2017) Fumihiko Yasuno et al.   NeuroImage-Clinical

M2 Phenotype Microglia-derived Cytokine Stimulates Proliferation and Neuronal Differentiation of Endogenous Stem Cells in Ischemic Brain

(2017) Ja Yong Choi et al.   Experimental Neurobiology

Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance

(2016) Xiao-dan Guo et al.   ACTA PHARMACOLOGICA SINICA

Anthocyanin effects on microglia M1/M2 phenotype: Consequence on neuronal fractalkine expression

(2016) Manuela Meireles et al.   BEHAVIOURAL BRAIN RESEARCH

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology

(2016) Daniela Pantano et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Epigallocatechin gallate attenuates amyloid β-induced inflammation and neurotoxicity in EOC 13.31 microglia

(2016) James Cheng-Chung Wei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Combined use of biochemical and volumetric biomarkers to assess the risk of conversion of mild cognitive impairment to Alzheimer’s disease

(2016) Marta Nesteruk et al.   FOLIA NEUROPATHOLOGICA

Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera

(2016) Hyun Ah Jung et al.   FOOD AND CHEMICAL TOXICOLOGY

2,3,4′,5-tetrahydroxystilbene-2-O-β-d-glucoside exerts anti-inflammatory effects on lipopolysaccharide-stimulated microglia by inhibiting NF-κB and activating AMPK/Nrf2 pathways

(2016) Sun Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer’s Disease

(2016) Vicent Bonet-Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors

(2016) Li Lang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A diet enriched with plant sterols prevents the memory impairment induced by cholesterol loss in senescence-accelerated mice

(2016) Azucena Pérez-Cañamás et al.   NEUROBIOLOGY OF AGING

Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages

(2016) Ye Won An et al.   NEUROBIOLOGY OF AGING

Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells

(2016) Dong Zhao et al.   NEUROCHEMICAL RESEARCH

A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype

(2016) Gyun Jee Song et al.   NEUROPHARMACOLOGY

Epigenetic modifications by inhibiting histone deacetylases reverse memory impairment in insulin resistance induced cognitive deficit in mice

(2016) Sorabh Sharma et al.   NEUROPHARMACOLOGY

Epicatechin plus treadmill exercise are neuroprotective against moderate-stage amyloid precursor protein/presenilin 1 mice

(2016) Houcai Huang et al.   Pharmacognosy Magazine

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling

(2016) Gang Wang et al.   Oncotarget

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease

(2016) Zun-Jing Liu et al.   Frontiers in Pharmacology

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

(2016) Manon Domise et al.   Scientific Reports

Compartmental and noncompartmental modeling of 13C-lycopene absorption, isomerization, and distribution kinetics in healthy adults

(2015) Nancy E Moran et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

(2015) Qiong Zhou et al.   ANNALS OF NEUROLOGY

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation

(2015) Yuan Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Endocannabinoids drive the acquisition of an alternative phenotype in microglia

(2015) M. Mecha et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells

(2015) Cheng-Fang Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotection of Brain-Targeted Bioactive Dietary Artoindonesianin O (AIO) from Mulberry on Rat Neurons as a Novel Intervention for Alzheimer’s Disease

(2015) Aimin Qiao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

(2015) Anand Kamal Sachdeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A novel phosphodiesterase-5 Inhibitor: Yonkenafil modulates neurogenesis, gliosis to improve cognitive function and ameliorates amyloid burden in an APP/PS1 transgenic mice model

(2015) Lei Zhu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Resveratrol inhibits oligomeric Aβ-induced microglial activation via NADPH oxidase

(2015) YAO YAO et al.   Molecular Medicine Reports

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

(2015) Ulf Neumann et al.   Molecular Neurodegeneration

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization

(2015) Dongjie Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia

(2015) Wanqiang Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

MH84: A Novel γ-Secretase Modulator/PPARγ Agonist—Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer’s Disease

(2015) Maximilian Pohland et al.   NEUROCHEMICAL RESEARCH

Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

(2015)   NEUROLOGY

Curcumin inhibits Aβ-induced microglial inflammatory responses in vitro: Involvement of ERK1/2 and p38 signaling pathways

(2015) Xiaolei Shi et al.   NEUROSCIENCE LETTERS

Protective role of caffeic acid in an Aβ25-35-induced Alzheimer's disease model

(2015) Ji Hyun Kim et al.   Nutrition Research and Practice

Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms inin vitroandin vivomodels of Alzheimer's disease

(2015) Miho Yoshida Yamakawa et al.   NUTRITIONAL NEUROSCIENCE

Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers

(2015) Farideh Asadi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Sulforaphane Ameliorates Neurobehavioral Deficits and Protects the Brain From Amyloid β Deposits and Peroxidation in Mice With Alzheimer-Like Lesions

(2014) Rui Zhang et al.   American Journal of Alzheimers Disease and Other Dementias

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

(2014) Federica Prati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation

(2014) Peng-xin Xu et al.   BEHAVIOURAL BRAIN RESEARCH

Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia

(2014) Jin-Woo Jeong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inhibition of AMP-Activated Protein Kinase Signaling Alleviates Impairments in Hippocampal Synaptic Plasticity Induced by Amyloid  

(2014) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Combined Treatment with a BACE Inhibitor and Anti-A  Antibody Gantenerumab Enhances Amyloid Reduction in APPLondon Mice

(2014) H. Jacobsen et al.   JOURNAL OF NEUROSCIENCE

Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β

(2014) Hye Rin Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

(2013) Junfang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer’s disease

(2013) Min-Young Noh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APPswe/PS1dE9 Transgenic Mice

(2013) Jian-Quan Shi et al.   CNS Neuroscience & Therapeutics

Polypharmacology in a Single Drug: Multitarget Drugs

(2013) M. L. Bolognesi   CURRENT MEDICINAL CHEMISTRY

Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer's Disease Mortality in Older Adults

(2013) Jin-young Min et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages

(2013) Hyun Ah Jung et al.   FOOD AND CHEMICAL TOXICOLOGY

Spreading depression features and Iba1 immunoreactivity in the cerebral cortex of developing rats submitted to treadmill exercise after treatment with monosodium glutamate

(2013) Cássia Borges Lima et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Fucoxanthin Ameliorates Inflammation and Oxidative Reponses in Microglia

(2013) Ratih Pangestuti et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanisms of Anti-inflammatory Property of Conserved Dopamine Neurotrophic Factor: Inhibition of JNK Signaling in Lipopolysaccharide-Induced Microglia

(2013) Hua Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Oral Administration of Histone Deacetylase Inhibitor MS-275 Ameliorates Neuroinflammation and Cerebral Amyloidosis and Improves Behavior in a Mouse Model

(2013) Zhi-Yuan Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

(2013) S. Eketjall et al.   JOURNAL OF NEUROSCIENCE

Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study

(2013) V. K. Burg et al.   JOURNAL OF NEUROSCIENCE

Pomegranate Polyphenols and Extract Inhibit Nuclear Factor of Activated T-Cell Activity and Microglial Activation In Vitro and in a Transgenic Mouse Model of Alzheimer Disease

(2013) Lalida Rojanathammanee et al.   JOURNAL OF NUTRITION

Neuritogenic Activity of Trichostatin A in Adult Rat Retinal Ganglion Cells Through Acetylation of Histone H3 Lysine 9 and RARβ Induction

(2013) Yoshiki Koriyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Home processing of tomatoes (Solanum lycopersicum): effects onin vitrobioaccessibility of total lycopene, phenolics, flavonoids, and antioxidant capacity

(2013) Senem Kamiloglu et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

(2013) Rocio Perez-Gonzalez et al.   NEUROBIOLOGY OF AGING

Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways

(2013) Hsiao-Yun Lin et al.   NEUROBIOLOGY OF AGING

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

(2013) A.S.R. Sierksma et al.   NEUROPHARMACOLOGY

Development of the microglial phenotype in culture

(2013) M. Szabo et al.   NEUROSCIENCE

Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain

(2013) Ilaria Luccarini et al.   NEUROSCIENCE LETTERS

Ferulic Acid Is a Nutraceutical β-Secretase Modulator That Improves Behavioral Impairment and Alzheimer-like Pathology in Transgenic Mice

(2013) Takashi Mori et al.   PLoS One

Markers of low-grade inflammation and endothelial dysfunction are related to reduced information processing speed and executive functioning in an older population – the Hoorn Study

(2013) S.M. Heringa et al.   PSYCHONEUROENDOCRINOLOGY

The Protective Role of Carnosic Acid against Beta-Amyloid Toxicity in Rats

(2013) H. Rasoolijazi et al.   TheScientificWorldJOURNAL

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

(2012) David Porquet et al.   AGE

Aging-dependent brain electrophysiological effects in rats after distinct lactation conditions, and treadmill exercise: A spreading depression analysis

(2012) Manuella Batista-de-Oliveira et al.   EXPERIMENTAL GERONTOLOGY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia

(2012) Holly F. Green et al.   NEUROCHEMISTRY INTERNATIONAL

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

(2012) Elisabetta Polazzi et al.   NEUROSIGNALS

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia

(2011) Mika Yanagitai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

(2011) Urte Neniskyte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells

(2010) Kyong Nyon Nam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PPARγ agonist pioglitazone inhibits microglia inflammation by blocking p38 mitogen-activated protein kinase signaling pathways

(2010) Huoyan Ji et al.   INFLAMMATION RESEARCH

Cytoprotective and anti-inflammatory effects of spinasterol via the induction of heme oxygenase-1 in murine hippocampal and microglial cell lines

(2010) Gil-Saeng Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Microglia and neuroprotection: From in vitro studies to therapeutic applications

(2010) Elisabetta Polazzi et al.   PROGRESS IN NEUROBIOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Isolation of a Human Intestinal Bacterium Capable of Daidzein and Genistein Conversion

(2009) A. Matthies et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sulforaphane suppresses LPS-induced inflammation in primary rat microglia

(2009) Lars-Ove Brandenburg et al.   INFLAMMATION RESEARCH

Neuroprotection of microglial conditioned medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2

(2009) Elisabetta Polazzi et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

(2009) Alessandro Michelucci et al.   JOURNAL OF NEUROIMMUNOLOGY

Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment

(2009) Gelin Xu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

(2009) Vanja Vukic et al.   NEUROBIOLOGY OF DISEASE

Interleukin-1β interferes with signal transduction induced by neurotrophin-3 in cortical neurons

(2007) Rungtip Soiampornkul et al.   BRAIN RESEARCH