Oral Administration of Histone Deacetylase Inhibitor MS-275 Ameliorates Neuroinflammation and Cerebral Amyloidosis and Improves Behavior in a Mouse Model

Sodium Butyrate Improves Memory Function in an Alzheimer's Disease Mouse Model When Administered at an Advanced Stage of Disease Progression

(2018) Nambirajan Govindarajan et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

(2017) Yitshak I. Francis et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

(2012) Ana María Martín-Moreno et al.   Journal of Neuroinflammation

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease

(2012) Haiqun Jia et al.   NEUROBIOLOGY OF DISEASE

Current and Emerging Drug Treatment Options for Alzheimerʼs Disease

(2011) Nathan Herrmann et al.   DRUGS

The role of histone acetylation in age-associated memory impairment and Alzheimer’s disease

(2011) Roman Manuel Stilling et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

(2011) S.K. Kidd et al.   NEUROSCIENCE

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

(2011) Ke Xu et al.   Oxidative Medicine and Cellular Longevity

HDAC inhibitor MS-275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis

(2011) Zhi-Yuan Zhang et al.   PROSTATE

Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories

(2011) Gayle Helane Doherty   Neuroscience Bulletin

Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease

(2010) Gaukhman Alexander et al.   BEHAVIOURAL BRAIN RESEARCH

Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice

(2010) Daniel W. Wesson et al.   BEHAVIOURAL BRAIN RESEARCH

Histone deacetylases as targets for the treatment of human neurodegenerative diseases

(2010) S.R. D'Mello   DRUG NEWS & PERSPECTIVES

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein

(2010) Vivek Venkataramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress and the epigenetic landscape: a link to the pathobiology of human diseases?

(2010) Sarah E. Johnstone et al.   NATURE REVIEWS GENETICS

MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis

(2010) Z.Y. Zhang et al.   NEUROSCIENCE

Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

(2010) Simon Gengler et al.   PLoS One

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The epigenetic bottleneck of neurodegenerative and psychiatric diseases

(2009) Farahnaz Sananbenesi et al.   BIOLOGICAL CHEMISTRY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats

(2008) Bin Zhang et al.   BRAIN RESEARCH

HDAC inhibitors in models of inflammation-related tumorigenesis

(2008) Rainer Glauben et al.   CANCER LETTERS

Valproic acid attenuates inflammation in experimental autoimmune neuritis

(2008) Z. Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

(2008) T ABEL et al.   CURRENT OPINION IN PHARMACOLOGY

FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves

(2008) Zhiren Zhang et al.   EXPERIMENTAL NEUROLOGY

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prevention of Hypoxia-Induced Neuronal Apoptosis Through Histone Deacetylase Inhibition

(2008) Yongqing Li et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE