MH84: A Novel γ-Secretase Modulator/PPARγ Agonist—Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer’s Disease
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
MH84: A Novel γ-Secretase Modulator/PPARγ Agonist—Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer’s Disease
Authors
Keywords
Alzheimer’s disease, Mitochondrial dysfunction, γ-Secretase modulators, PPARγ-agonists, PGC1α, Multifunctional agents, Drug candidate
Journal
NEUROCHEMICAL RESEARCH
Volume 41, Issue 1-2, Pages 231-242
Publisher
Springer Nature
Online
2015-12-31
DOI
10.1007/s11064-015-1765-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice
- (2017) Natasa Dragicevic et al. JOURNAL OF ALZHEIMERS DISEASE
- Dimebon (Latrepirdine) Enhances Mitochondrial Function and Protects Neuronal Cells from Death
- (2017) Shouting Zhang et al. JOURNAL OF ALZHEIMERS DISEASE
- SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer’s disease
- (2015) Daniel Flesch et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Current Practices in the Treatment of Alzheimer Disease: Where is the Evidence After the Phase III Trials?
- (2015) Megan J. Ehret et al. CLINICAL THERAPEUTICS
- The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis
- (2015) Huawei Cheng et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP
- (2015) April M. Weissmiller et al. PLoS One
- Dimebon Attenuates the Aβ-Induced Mitochondrial Permeabilization
- (2014) Elena Shevtsova et al. Current Alzheimer Research
- Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease
- (2014) Natalia Guzior et al. CURRENT MEDICINAL CHEMISTRY
- PPAR Recruitment to Active ERK during Memory Consolidation Is Required for Alzheimer's Disease-Related Cognitive Enhancement
- (2014) J. B. Jahrling et al. JOURNAL OF NEUROSCIENCE
- Sustained 4-year Cognitive and Functional Response in Early Alzheimer's Disease with Pioglitazone
- (2014) Stephen Read et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP
- (2013) Ari Robinson et al. AGING CELL
- The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives
- (2013) Russell H. Swerdlow et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation
- (2012) Kristina Leuner et al. ANTIOXIDANTS & REDOX SIGNALING
- Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease
- (2012) Vladimir Coric et al. ARCHIVES OF NEUROLOGY
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
- (2012) Francesc X. Guix et al. EMBO Molecular Medicine
- Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD)
- (2012) Walter J Lukiw EXPERT OPINION ON EMERGING DRUGS
- PGC1 and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders
- (2012) S. Austin et al. JOURNAL OF CELL SCIENCE
- Differential Effects between -Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice
- (2012) Y. Mitani et al. JOURNAL OF NEUROSCIENCE
- Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects
- (2012) Steen Larsen et al. JOURNAL OF PHYSIOLOGY-LONDON
- Mitochondrial Dysfunction—A Pharmacological Target in Alzheimer's Disease
- (2012) Gunter P. Eckert et al. MOLECULAR NEUROBIOLOGY
- Assessing mitochondrial dysfunction in cells
- (2011) Martin D. Brand et al. BIOCHEMICAL JOURNAL
- SAR studies of acidic dual γ-secretase/PPARγ modulators
- (2011) Martina Hieke et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells
- (2011) Li-min Chen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice
- (2011) Latha Devi et al. NEUROBIOLOGY OF DISEASE
- SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function
- (2010) Bing Gong et al. AGING CELL
- Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein
- (2010) Pavel F. Pavlov et al. FASEB JOURNAL
- Design, Synthesis, and Biological Evaluation of a Novel Class of γ-Secretase Modulators with PPARγ Activity
- (2010) Martina Hieke et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects
- (2010) Walter E. Müller et al. MOLECULAR NEUROBIOLOGY
- Dimebon Inhibits Calcium-Induced Swelling of Rat Brain Mitochondria But Does Not Alter Calcium Retention or Cytochrome C Release
- (2010) Kranthi Kumari Naga et al. NEUROMOLECULAR MEDICINE
- Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
- (2010) Kevin W. Gillman et al. ACS Medicinal Chemistry Letters
- Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment
- (2009) Francesca Mangialasche et al. AGEING RESEARCH REVIEWS
- The interaction of beta-amyloid protein with cellular membranes stimulates its own production
- (2009) Imke Peters et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Alzheimer's disease: new approaches to drug discovery
- (2009) Maria L Bolognesi et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Development of semagacestat (LY450139), a functional γ-secretase inhibitor, for the treatment of Alzheimer's disease
- (2009) David B Henley et al. EXPERT OPINION ON PHARMACOTHERAPY
- PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss
- (2009) Gianluca Miglio et al. NEUROCHEMISTRY INTERNATIONAL
- Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
- (2003) H. F. Dovey et al. JOURNAL OF NEUROCHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search