Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Fumarase: a paradigm of dual targeting and dual localized functions

(2011) Ohad Yogev et al.   FEBS Journal

The Aconitase C-Terminal Domain Is an Independent Dual Targeting Element

(2011) Reut Ben-Menachem et al.   JOURNAL OF MOLECULAR BIOLOGY

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Dual targeting of mitochondrial proteins: Mechanism, regulation and function

(2010) Ohad Yogev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitophagy and Parkinson's disease: The PINK1–parkin link

(2010) Emma Deas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural determinants of PINK1 topology and dual subcellular distribution

(2010) William Lin et al.   BMC CELL BIOLOGY

Cooperation of Stop-Transfer and Conservative Sorting Mechanisms in Mitochondrial Protein Transport

(2010) Maria Bohnert et al.   CURRENT BIOLOGY

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Tickled PINK1: Mitochondrial homeostasis and autophagy in recessive Parkinsonism

(2009) Charleen T. Chu   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

PINK1 function in health and disease

(2009) Emma Deas et al.   EMBO Molecular Medicine

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

(2009) Brian Head et al.   JOURNAL OF CELL BIOLOGY

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux

(2009) Roberta Marongiu et al.   JOURNAL OF NEUROCHEMISTRY

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

(2009) Kvido Strisovsky et al.   MOLECULAR CELL

PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

(2009) Wencheng Liu et al.   PLoS One

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhomboid Proteases and their Biological Functions

(2008) Matthew Freeman   Annual Review of Genetics

Sorting and assembly of mitochondrial outer membrane proteins

(2008) Thomas Becker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway

(2008) Birthe Meineke et al.   FEBS LETTERS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Characterization of PINK1 processing, stability, and subcellular localization

(2008) William Lin et al.   JOURNAL OF NEUROCHEMISTRY

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP

(2008) M. E. Haque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The kinase domain of mitochondrial PINK1 faces the cytoplasm

(2008) C. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1

(2007) Sho Takatori et al.   NEUROSCIENCE LETTERS