The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression

“Vitamin S” (Steroids) and Vitamin C for the Treatment of Severe Sepsis and Septic Shock!*

(2016) Paul E. Marik   CRITICAL CARE MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Vitamin C Facilitates Demethylation of theFoxp3Enhancer in a Tet-Dependent Manner

(2016) Varun Sasidharan Nair et al.   JOURNAL OF IMMUNOLOGY

Neuropilin-1highCD4+CD25+Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis

(2016) Yu-Lei Gao et al.   MEDIATORS OF INFLAMMATION

Relevance of Foxp3+regulatory T cells for early and late phases of murine sepsis

(2015) Roman Tatura et al.   IMMUNOLOGY

Effect of Regulatory T Cells on Promoting Apoptosis of T Lymphocyte and Its Regulatory Mechanism in Sepsis

(2015) Ying-yi Luan et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis

(2015) Kirsi-Maija Kaukonen et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Reduction of Peripheral Blood CD4+ T Cell Indicates Persistent Organ Failure in Acute Pancreatitis

(2015) Zhiyong Yang et al.   PLoS One

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

(2015) H.-J. Kim et al.   SCIENCE

Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice

(2015) Yu-Lei Gao et al.   Scientific Reports

Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells

(2014) Mirelle J. A. J. Huijskens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulation of LPS-Induced CD4+ T-Cell Activation and Apoptosis by Antioxidants in Untreated Asymptomatic HIV Infected Participants: AnIn VitroStudy

(2013) S. Mburu et al.   Clinical & Developmental Immunology

Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*

(2013) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Reduction of Immunocompetent T Cells Followed by Prolonged Lymphopenia in Severe Sepsis in the Elderly*

(2013) Shigeaki Inoue et al.   CRITICAL CARE MEDICINE

Attenuation of Sepsis-Induced Organ Injury in Mice by Vitamin C

(2013) Bernard J. Fisher et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Vitamin C Promotes Maturation of T-Cells

(2012) Jared Manning et al.   ANTIOXIDANTS & REDOX SIGNALING

Advances in the Management of Sepsis and the Understanding of Key Immunologic Defects

(2011) Lee P. Skrupky et al.   ANESTHESIOLOGY

High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4

(2011) Xiao-Mei Zhu et al.   CYTOKINE

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis

(2010) Daniele C. Nascimento et al.   CRITICAL CARE MEDICINE

Long-term mortality and quality of life in sepsis: A systematic review*

(2010) Bradford D. Winters et al.   CRITICAL CARE MEDICINE

IL-2-Controlled Expression of Multiple T Cell Trafficking Genes and Th2 Cytokines in the Regulatory T Cell-Deficient Scurfy Mice: Implication to Multiorgan Inflammation and Control of Skin and Lung Inflammation

(2010) R. Sharma et al.   JOURNAL OF IMMUNOLOGY

The Potential Effect and Mechanism of High-Mobility Group Box 1 Protein on Regulatory T Cell-Mediated Immunosuppression

(2010) Ying Zhang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH